Difference between revisions of "NS-pathway control state"
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{{MitoPedia | {{MitoPedia | ||
|abbr=NS-state | |abbr=NS-state | ||
|description=The '''Complex I<small>&</small>II-linked substrate state | |description=The '''NS-linked substrate state''' (Complex I<small>&</small>II-linked substrate state) is induced in mt-preparations by addition of [[NADH]]-generating substrates (N-linked) in combination with succinate (S- or CII-linked). This physiological substrate combination is required for partial reconstiturion of [[TCA cycle]] function and convergent electron-input into the [[Q-junction]] to compensate for metabolite depletion into the incubation medium. An [[Additive effect of convergent NS-electron flow]] is observed in most types of mitochondria. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
Revision as of 19:58, 20 March 2016
- high-resolution terminology - matching measurements at high-resolution
NS-pathway control state
Description
The NS-linked substrate state (Complex I&II-linked substrate state) is induced in mt-preparations by addition of NADH-generating substrates (N-linked) in combination with succinate (S- or CII-linked). This physiological substrate combination is required for partial reconstiturion of TCA cycle function and convergent electron-input into the Q-junction to compensate for metabolite depletion into the incubation medium. An Additive effect of convergent NS-electron flow is observed in most types of mitochondria.
Abbreviation: NS-state
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory state
MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property. SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
MitoPedia topics:
Substrate and metabolite
