Difference between revisions of "NADH"
| Line 1: | Line 1: | ||
{{MitoPedia | {{MitoPedia | ||
|abbr=NADH | |abbr=n, NADH | ||
|description='''Nicotinadeninedinucleotide (NADH)''' is not permeable through the inner mt-membrane. The NADH pool integrates the activity of the [[TCA cycle]] and various matrix dehydrogenases upstream of [[CI]], and thus forms a junction or funnel of electron transfer to CI. Cytosolic NADH is effectively made available for mitochondrial respiration through the [[malate-aspartate shuttle]] or [[Glycerophosphate_dehydrogenase_complex|glycerophosphate dehydrogenase]]. | |description='''Nicotinadeninedinucleotide (NADH)''' is not permeable through the inner mt-membrane. The NADH pool integrates the activity of the [[TCA cycle]] and various matrix dehydrogenases upstream of [[CI]], and thus forms a junction or funnel of electron transfer to CI. Cytosolic NADH is effectively made available for mitochondrial respiration through the [[malate-aspartate shuttle]] or [[Glycerophosphate_dehydrogenase_complex|glycerophosphate dehydrogenase]]. | ||
|type=Substrate ETS | |type=Substrate ETS | ||
| Line 11: | Line 11: | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|enzymes= | |enzymes=Complex I | ||
}} | }} | ||
== Application in [[HRR]] == | == Application in [[HRR]] == | ||
'''n: Nicotinadeninedinucleotide, NADH''' (β-Nicotinamide adenine dinucleotide, reduced potassium salt, C<sub>21</sub>H<sub>27</sub>N<sub>7</sub>O<sub>14</sub>P<sub>2</sub>K<sub>2</sub>); Sigma A 4505, 100 mg, store at -20 °C (old Sigma recommendation : 4-8°); FW = 742.61, for important considerations concerning storage of NADH (powder and solutions) and preparation of solutions see the product information from Sigma: [https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Product_Information_Sheet/2/n4505pis.pdf]. The same precautions are recommended by Sigma for the sodium salt. | |||
''' | |||
Revision as of 09:35, 21 January 2016
- high-resolution terminology - matching measurements at high-resolution
NADH
Description
Nicotinadeninedinucleotide (NADH) is not permeable through the inner mt-membrane. The NADH pool integrates the activity of the TCA cycle and various matrix dehydrogenases upstream of CI, and thus forms a junction or funnel of electron transfer to CI. Cytosolic NADH is effectively made available for mitochondrial respiration through the malate-aspartate shuttle or glycerophosphate dehydrogenase.
Abbreviation: n, NADH
MitoPedia topics: Substrate and metabolite
Labels:
Enzyme: Complex I
Application in HRR
n: Nicotinadeninedinucleotide, NADH (β-Nicotinamide adenine dinucleotide, reduced potassium salt, C21H27N7O14P2K2); Sigma A 4505, 100 mg, store at -20 °C (old Sigma recommendation : 4-8°); FW = 742.61, for important considerations concerning storage of NADH (powder and solutions) and preparation of solutions see the product information from Sigma: [1]. The same precautions are recommended by Sigma for the sodium salt.
