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N-junction

From Bioblast


high-resolution terminology - matching measurements at high-resolution


N-junction

Description

N-junction

The N-junction is a junction for convergent electron flow in the electron transfer system (ETS) from type N substrates (further details Β»N-pathway control state) through the mt-NADH pool to Complex I (CI), and further transfer through the Q-junction to Complex III (CIII). Representative type N substrates are pyruvate, glutamate and malate. The corresponding dehydrogenases (PDH, GDH, MDH) generate NADH, the substrate of Complex I (CI). The concept of the N-junction and F-junction provides a basis for defining categories of SUIT protocols based on pathway control states.


Reference: N-pathway control state


MitoPedia concepts: MiP concept, SUIT concept 


MitoPedia methods: Respirometry 

Contributed by Gnaiger E 2016-02-12; edited 2016-08-28.