Difference between revisions of "N-junction"
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|description=[[File:SUIT-catg N.jpg|right|300px|N-junction]] | |description=[[File:SUIT-catg N.jpg|right|300px|N-junction]] | ||
The '''N-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] (ETS) from type N substrates (''further details'' »[[N-pathway control state]]) through the mt-[[NADH]] pool to [[Complex I]] (CI), and further transfer through the [[Q-junction]] to [[Complex III]] (CIII). Representative type N substrates are pyruvate, glutamate and malate. The corresponding dehydrogenases (PDH, GDH, MDH) generate NADH, the substrate of [[Complex I]] (CI). The concept of the N-junction and [[F-junction]] provides a basis for defining [[categories of SUIT protocols]] based on [[pathway control state]]s. | The '''N-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] (ETS) from type N substrates (''further details'' »[[N-pathway control state]]) through the mt-[[NADH]] pool to [[Complex I]] (CI), and further transfer through the [[Q-junction]] to [[Complex III]] (CIII). Representative type N substrates are pyruvate (P), glutamate (G) and malate (M). The corresponding dehydrogenases ([[Pyruvate dehydrogenase |PDH]], [[Glutamate dehydrogenase |GDH]], [[Malate dehydrogenase |MDH]]) and some additional TCA cycle dehydrogenases ([[isocitrate dehydrogenase]], [[oxoglutarate dehydrogenase]] generate NADH, the substrate of [[Complex I]] (CI). The concept of the N-junction and [[F-junction]] provides a basis for defining [[categories of SUIT protocols]] based on [[pathway control state]]s. | ||
|info=[[N-pathway control state]] | |info=[[N-pathway control state]] | ||
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|mitopedia method=Respirometry | |mitopedia method=Respirometry | ||
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Contributed by [[Gnaiger E]] 2016-02-12; edited 2016-08-28. | Contributed by [[Gnaiger E]] 2016-02-12; edited 2016-08-28, 2017-01-03. | ||
Revision as of 08:30, 3 January 2017
- high-resolution terminology - matching measurements at high-resolution
N-junction
Description
The N-junction is a junction for convergent electron flow in the electron transfer system (ETS) from type N substrates (further details »N-pathway control state) through the mt-NADH pool to Complex I (CI), and further transfer through the Q-junction to Complex III (CIII). Representative type N substrates are pyruvate (P), glutamate (G) and malate (M). The corresponding dehydrogenases (PDH, GDH, MDH) and some additional TCA cycle dehydrogenases (isocitrate dehydrogenase, oxoglutarate dehydrogenase generate NADH, the substrate of Complex I (CI). The concept of the N-junction and F-junction provides a basis for defining categories of SUIT protocols based on pathway control states.
Reference: N-pathway control state
MitoPedia concepts:
MiP concept,
SUIT concept
MitoPedia methods:
Respirometry
Contributed by Gnaiger E 2016-02-12; edited 2016-08-28, 2017-01-03.
