Difference between revisions of "N-junction"
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The '''N-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] (ETS) from [[N-linked substrate state |type N substrates]] through the mt-[[NADH]] pool to [[Complex I]] (CI), and further transfer through the [[Q-junction]] to [[Complex III]] (CIII). Representative type N substrates are pyruvate, glutamate and malate. The corresponding dehydrogenases (PDH, GDH, MDH) generate NADH, the substrate of [[Complex I]] (CI). The concept of the N-junction and [[F-junction]] provides a basis for defining [[categories of SUIT protocols]] based on [[substrate control states]]. | The '''N-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] (ETS) from [[N-linked substrate state |type N substrates]] through the mt-[[NADH]] pool to [[Complex I]] (CI), and further transfer through the [[Q-junction]] to [[Complex III]] (CIII). Representative type N substrates are pyruvate, glutamate and malate. The corresponding dehydrogenases (PDH, GDH, MDH) generate NADH, the substrate of [[Complex I]] (CI). The concept of the N-junction and [[F-junction]] provides a basis for defining [[categories of SUIT protocols]] based on [[substrate control states]]. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
}} | |||
{{MitoPedia concepts | |||
|mitopedia concept=MiP concept, SUIT concept | |||
}} | }} | ||
{{MitoPedia methods | {{MitoPedia methods | ||
|mitopedia method=Respirometry | |mitopedia method=Respirometry | ||
}} | }} | ||
{{MitoPedia O2k and high-resolution respirometry | {{MitoPedia O2k and high-resolution respirometry}} | ||
{{MitoPedia topics}} | |||
}} | Contributed by [[Gnaiger E]] 2016-02-12 | ||
Revision as of 16:36, 13 May 2016
- high-resolution terminology - matching measurements at high-resolution
N-junction
Description
The N-junction is a junction for convergent electron flow in the electron transfer system (ETS) from type N substrates through the mt-NADH pool to Complex I (CI), and further transfer through the Q-junction to Complex III (CIII). Representative type N substrates are pyruvate, glutamate and malate. The corresponding dehydrogenases (PDH, GDH, MDH) generate NADH, the substrate of Complex I (CI). The concept of the N-junction and F-junction provides a basis for defining categories of SUIT protocols based on substrate control states.
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
MiP concept,
SUIT concept
MitoPedia methods:
Respirometry
Contributed by Gnaiger E 2016-02-12
