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Most 2017 Eur J Clin Nutr - Revision history
2024-03-29T15:40:52Z
Revision history for this page on the wiki
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Gnaiger Erich at 07:12, 27 January 2020
2020-01-27T07:12:13Z
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Most_2017_Eur_J_Clin_Nutr&diff=158174&oldid=prev
Krumschnabel Gerhard at 08:01, 11 June 2018
2018-06-11T08:01:21Z
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Krumschnabel Gerhard
https://wiki.oroboros.at/index.php?title=Most_2017_Eur_J_Clin_Nutr&diff=155570&oldid=prev
Radis Christina at 14:49, 27 March 2018
2018-03-27T14:49:56Z
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Radis Christina
https://wiki.oroboros.at/index.php?title=Most_2017_Eur_J_Clin_Nutr&diff=141990&oldid=prev
Kandolf Georg: Created page with "{{Publication |title=Most J, Penders J, Lucchesi M, Goossens GH, Blaak EE (2017) Gut microbiota composition in relation to the metabolic response to 12-week combined polypheno..."
2017-08-30T12:42:10Z
<p>Created page with "{{Publication |title=Most J, Penders J, Lucchesi M, Goossens GH, Blaak EE (2017) Gut microbiota composition in relation to the metabolic response to 12-week combined polypheno..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Most J, Penders J, Lucchesi M, Goossens GH, Blaak EE (2017) Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women. Eur J Clin Nutr [Epub ahead of print].<br />
|info=[https://www.ncbi.nlm.nih.gov/pubmed/28589947 PMID: 28589947]<br />
|authors=Most J, Penders J, Lucchesi M, Goossens GH, Blaak EE<br />
|year=2017<br />
|journal=Eur J Clin Nutr<br />
|abstract=The intestinal microbiota may have a profound impact on host metabolism. As evidence suggests that polyphenols affect substrate utilization, the present study aimed to investigate the effects of polyphenol supplementation on intestinal microbiota composition in humans. Furthermore, we examined whether (changes in) gut microbiota composition may determine the metabolic response to polyphenol supplementation.<br />
<br />
In this randomized, double-blind, placebo (PLA)-controlled trial, 37 overweight and obese men and women (18 males/19 females, 37.8±1.6 years, body mass index: 29.6±0.5 kg/m2) received either epigallocatechin-3-gallate and resveratrol (EGCG+RES, 282 and 80 mg/day, respectively) or PLA for 12 weeks. Before and after intervention, feces samples were collected to determine microbiota composition. Fat oxidation was assessed by indirect calorimetry during a high-fat mixed meal test (2.6 MJ, 61 energy% fat) and skeletal muscle mitochondrial oxidative capacity by means of ex vivo respirometry on isolated skeletal muscle fibers. Body composition was measured by dual-energy X-ray absorptiometry.<br />
<br />
Fecal abundance of Bacteroidetes was higher in men as compared with women, whereas other assessed bacterial taxa were comparable. EGCG+RES supplementation significantly decreased Bacteroidetes and tended to reduce Faecalibacterium prausnitzii in men (P=0.05 and P=0.10, respectively) but not in women (P=0.15 and P=0.77, respectively). Strikingly, baseline Bacteroidetes abundance was predictive for the EGCG+RES-induced increase in fat oxidation in men but not in women. Other bacterial genera and species were not affected by EGCG+RES supplementation.<br />
<br />
We demonstrated that 12-week EGCG+RES supplementation affected the gut microbiota composition in men but not in women. Baseline microbiota composition determined the increase in fat oxidation after EGCG+RES supplementation in men.<br />
|editor=[[Kandolf G]]<br />
}}<br />
{{Labeling<br />
|area=Respiration, Pharmacology;toxicology<br />
|diseases=Obesity<br />
|organism=Human<br />
|tissues=Skeletal muscle<br />
|preparations=Permeabilized tissue<br />
|instruments=Oxygraph-2k<br />
|additional=Labels, 2017-08<br />
}}</div>
Kandolf Georg