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Montero 2015 J Physiol - Revision history
2024-03-29T13:07:31Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Montero_2015_J_Physiol&diff=155662&oldid=prev
Beno Marija at 10:04, 28 March 2018
2018-03-28T10:04:24Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ABSTRACT:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ABSTRACT:</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>It remains unclear whether improvements in peak oxygen uptake (V̇O2 peak ) following endurance training (ET) are primarily determined by central and/or peripheral adaptations. Herein, we tested the hypothesis that the improvement in V̇O2 peak following 6 weeks of ET is mainly determined by haematological rather than skeletal muscle adaptations. Sixteen untrained healthy male volunteers (age = 25 ± 4 years, V̇O2 peak = 3.5 ± 0.5 l min-1 ) underwent supervised ET (6 weeks, 3-4 sessions per week). V̇O2 peak , peak cardiac output (Q̇ peak ), haemoglobin mass (Hbmass ) and blood volumes were assessed prior to and following ET. Skeletal muscle biopsies were analysed for mitochondrial volume density (MitoVD ), capillarity, fibre types and respiratory capacity (OXPHOS). After the post-ET assessment, red blood cell volume (RBCV) was re-established at the pre-ET level by phlebotomy and V̇O2 peak and Q̇ peak were measured again. We speculated that the contribution of skeletal muscle adaptations to the ET-induced increase in V̇O2 peak would be revealed when controlling for haematological adaptations. V̇O2 peak and Q̇ peak were increased (P < 0.05) following ET (9 ± 8 and 7 ± 6%, respectively) and decreased (P < 0.05) after phlebotomy (-7 ± 7 and -10 ± 7%). RBCV, plasma volume and Hbmass all increased (P < 0.05) after ET (8 ± 4, 4 ± 6 and 6 ± 5%). As for skeletal muscle adaptations, capillary-to-fibre ratio and total MitoVD increased (P < 0.05) following ET (18 ± 16 and 43 ± 30%), but OXPHOS remained unaltered. Through stepwise multiple regression analysis, Q̇ peak , RBCV and Hbmass were found to be independent predictors of V̇O2 peak . In conclusion, the improvement in V̇O2 peak following 6 weeks of ET is primarily attributed to increases in Q̇ peak and oxygen-carrying capacity of blood in untrained healthy young subjects.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>It remains unclear whether improvements in peak oxygen uptake (V̇O2 peak ) following endurance training (ET) are primarily determined by central and/or peripheral adaptations. Herein, we tested the hypothesis that the improvement in V̇O2 peak following 6 weeks of ET is mainly determined by haematological rather than skeletal muscle adaptations. Sixteen untrained healthy male volunteers (age = 25 ± 4 years, V̇O2 peak = 3.5 ± 0.5 l min-1 ) underwent supervised ET (6 weeks, 3-4 sessions per week). V̇O2 peak , peak cardiac output (Q̇ peak ), haemoglobin mass (Hbmass ) and blood volumes were assessed prior to and following ET. Skeletal muscle biopsies were analysed for mitochondrial volume density (MitoVD ), capillarity, fibre types and respiratory capacity (OXPHOS). After the post-ET assessment, red blood cell volume (RBCV) was re-established at the pre-ET level by phlebotomy and V̇O2 peak and Q̇ peak were measured again. We speculated that the contribution of skeletal muscle adaptations to the ET-induced increase in V̇O2 peak would be revealed when controlling for haematological adaptations. V̇O2 peak and Q̇ peak were increased (P < 0.05) following ET (9 ± 8 and 7 ± 6%, respectively) and decreased (P < 0.05) after phlebotomy (-7 ± 7 and -10 ± 7%). RBCV, plasma volume and Hbmass all increased (P < 0.05) after ET (8 ± 4, 4 ± 6 and 6 ± 5%). As for skeletal muscle adaptations, capillary-to-fibre ratio and total MitoVD increased (P < 0.05) following ET (18 ± 16 and 43 ± 30%), but OXPHOS remained unaltered. Through stepwise multiple regression analysis, Q̇ peak , RBCV and Hbmass were found to be independent predictors of V̇O2 peak . In conclusion, the improvement in V̇O2 peak following 6 weeks of ET is primarily attributed to increases in Q̇ peak and oxygen-carrying capacity of blood in untrained healthy young subjects.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=CH Zurich Gassmann M, CH Zurich Lundby C, CH Zurich University of Zurich Physiology</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=CH Zurich Gassmann M, CH Zurich Lundby C, CH Zurich University of Zurich Physiology<ins style="font-weight: bold; text-decoration: none;">, US CO Colorado Springs Jacobs RA</ins></div></td></tr>
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Beno Marija
https://wiki.oroboros.at/index.php?title=Montero_2015_J_Physiol&diff=145678&oldid=prev
Kandolf Georg at 13:26, 13 November 2017
2017-11-13T13:26:04Z
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Montero_2015_J_Physiol&diff=102117&oldid=prev
Zhang Feiyuan at 14:15, 12 January 2016
2016-01-12T14:15:46Z
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Zhang Feiyuan
https://wiki.oroboros.at/index.php?title=Montero_2015_J_Physiol&diff=102116&oldid=prev
Zhang Feiyuan at 14:15, 12 January 2016
2016-01-12T14:15:32Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:15, 12 January 2016</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol <del style="font-weight: bold; text-decoration: none;">[Epub ahead of print]</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol <ins style="font-weight: bold; text-decoration: none;">593:4677-88</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[http://www.ncbi.nlm.nih.gov/pubmed/26282186 PMID: 26282186]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[http://www.ncbi.nlm.nih.gov/pubmed/26282186 PMID: 26282186]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Montero D, Cathomen A, Jacobs RA, Flueck D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Montero D, Cathomen A, Jacobs RA, Flueck D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C</div></td></tr>
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Zhang Feiyuan
https://wiki.oroboros.at/index.php?title=Montero_2015_J_Physiol&diff=98670&oldid=prev
Kandolf Georg at 11:39, 9 October 2015
2015-10-09T11:39:32Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol [Epub ahead of print]. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol [Epub ahead of print].</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[http://www.ncbi.nlm.nih.gov/pubmed/26282186 PMID: 26282186]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[http://www.ncbi.nlm.nih.gov/pubmed/26282186 PMID: 26282186]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|authors=Montero D, Cathomen A, Jacobs RA, <del style="font-weight: bold; text-decoration: none;">Flück </del>D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|authors=Montero D, Cathomen A, Jacobs RA, <ins style="font-weight: bold; text-decoration: none;">Flueck </ins>D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2015</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2015</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|journal=J Physiol</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|journal=J Physiol</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=KEY POINTS:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=KEY POINTS:</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>This study assessed the respective contributions of haematological and skeletal muscle adaptations to any observed improvement in peak oxygen uptake (<del style="font-weight: bold; text-decoration: none;">V̇O2 </del>peak ) induced by endurance training (ET). <del style="font-weight: bold; text-decoration: none;">V̇O2 </del>peak , peak cardiac output (Q̇ peak ), blood volumes and skeletal muscle biopsies were assessed prior (pre) to and after (post) 6 weeks of ET. Following the post-ET assessment, red blood cell volume (RBCV) reverted to the pre-ET level following phlebotomy and <del style="font-weight: bold; text-decoration: none;">V̇O2 </del>peak and Q̇ peak were determined again. We speculated that the contribution of skeletal muscle adaptations to an ET-induced increase in <del style="font-weight: bold; text-decoration: none;">V̇O2 </del>peak could be identified when offsetting the ET-induced increase in RBCV. <del style="font-weight: bold; text-decoration: none;">V̇O2 </del>peak , Q̇ peak , blood volumes, skeletal muscle mitochondrial volume density and capillarization were increased after ET. Following RBCV normalization, <del style="font-weight: bold; text-decoration: none;">V̇O2 </del>peak and Q̇ peak reverted to pre-ET levels. These results demonstrate the predominant contribution of haematological adaptations to any increase in <del style="font-weight: bold; text-decoration: none;">V̇O2 </del>peak induced by ET.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>This study assessed the respective contributions of haematological and skeletal muscle adaptations to any observed improvement in peak oxygen uptake (<ins style="font-weight: bold; text-decoration: none;">VO<sub>2</sub> </ins>peak ) induced by endurance training (ET). <ins style="font-weight: bold; text-decoration: none;">VO<sub>2</sub> </ins>peak , peak cardiac output (Q̇ peak ), blood volumes and skeletal muscle biopsies were assessed prior (pre) to and after (post) 6 weeks of ET. Following the post-ET assessment, red blood cell volume (RBCV) reverted to the pre-ET level following phlebotomy and <ins style="font-weight: bold; text-decoration: none;">VO<sub>2</sub> </ins>peak and Q̇ peak were determined again. We speculated that the contribution of skeletal muscle adaptations to an ET-induced increase in <ins style="font-weight: bold; text-decoration: none;">VO<sub>2</sub> </ins>peak could be identified when offsetting the ET-induced increase in RBCV. <ins style="font-weight: bold; text-decoration: none;">VO<sub>2</sub> </ins>peak , Q̇ peak , blood volumes, skeletal muscle mitochondrial volume density and capillarization were increased after ET. Following RBCV normalization, <ins style="font-weight: bold; text-decoration: none;">VO<sub>2</sub> </ins>peak and Q̇ peak reverted to pre-ET levels. These results demonstrate the predominant contribution of haematological adaptations to any increase in <ins style="font-weight: bold; text-decoration: none;">VO<sub>2</sub> </ins>peak induced by ET.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ABSTRACT:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ABSTRACT:</div></td></tr>
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<td colspan="2" class="diff-lineno">Line 19:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|couplingstates=OXPHOS, ETS</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|couplingstates=OXPHOS, ETS</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|instruments=Oxygraph-2k</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|instruments=Oxygraph-2k</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|additional=[Epub ahead of print]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
</table>
Kandolf Georg
https://wiki.oroboros.at/index.php?title=Montero_2015_J_Physiol&diff=98664&oldid=prev
Krumschnabel Gerhard: Created page with "{{Publication |title=Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adapt..."
2015-10-09T09:11:12Z
<p>Created page with "{{Publication |title=Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adapt..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol [Epub ahead of print]. <br />
|info=[http://www.ncbi.nlm.nih.gov/pubmed/26282186 PMID: 26282186]<br />
|authors=Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C<br />
|year=2015<br />
|journal=J Physiol<br />
|abstract=KEY POINTS:<br />
This study assessed the respective contributions of haematological and skeletal muscle adaptations to any observed improvement in peak oxygen uptake (V̇O2 peak ) induced by endurance training (ET). V̇O2 peak , peak cardiac output (Q̇ peak ), blood volumes and skeletal muscle biopsies were assessed prior (pre) to and after (post) 6 weeks of ET. Following the post-ET assessment, red blood cell volume (RBCV) reverted to the pre-ET level following phlebotomy and V̇O2 peak and Q̇ peak were determined again. We speculated that the contribution of skeletal muscle adaptations to an ET-induced increase in V̇O2 peak could be identified when offsetting the ET-induced increase in RBCV. V̇O2 peak , Q̇ peak , blood volumes, skeletal muscle mitochondrial volume density and capillarization were increased after ET. Following RBCV normalization, V̇O2 peak and Q̇ peak reverted to pre-ET levels. These results demonstrate the predominant contribution of haematological adaptations to any increase in V̇O2 peak induced by ET.<br />
<br />
ABSTRACT:<br />
It remains unclear whether improvements in peak oxygen uptake (V̇O2 peak ) following endurance training (ET) are primarily determined by central and/or peripheral adaptations. Herein, we tested the hypothesis that the improvement in V̇O2 peak following 6 weeks of ET is mainly determined by haematological rather than skeletal muscle adaptations. Sixteen untrained healthy male volunteers (age = 25 ± 4 years, V̇O2 peak = 3.5 ± 0.5 l min-1 ) underwent supervised ET (6 weeks, 3-4 sessions per week). V̇O2 peak , peak cardiac output (Q̇ peak ), haemoglobin mass (Hbmass ) and blood volumes were assessed prior to and following ET. Skeletal muscle biopsies were analysed for mitochondrial volume density (MitoVD ), capillarity, fibre types and respiratory capacity (OXPHOS). After the post-ET assessment, red blood cell volume (RBCV) was re-established at the pre-ET level by phlebotomy and V̇O2 peak and Q̇ peak were measured again. We speculated that the contribution of skeletal muscle adaptations to the ET-induced increase in V̇O2 peak would be revealed when controlling for haematological adaptations. V̇O2 peak and Q̇ peak were increased (P < 0.05) following ET (9 ± 8 and 7 ± 6%, respectively) and decreased (P < 0.05) after phlebotomy (-7 ± 7 and -10 ± 7%). RBCV, plasma volume and Hbmass all increased (P < 0.05) after ET (8 ± 4, 4 ± 6 and 6 ± 5%). As for skeletal muscle adaptations, capillary-to-fibre ratio and total MitoVD increased (P < 0.05) following ET (18 ± 16 and 43 ± 30%), but OXPHOS remained unaltered. Through stepwise multiple regression analysis, Q̇ peak , RBCV and Hbmass were found to be independent predictors of V̇O2 peak . In conclusion, the improvement in V̇O2 peak following 6 weeks of ET is primarily attributed to increases in Q̇ peak and oxygen-carrying capacity of blood in untrained healthy young subjects.<br />
|mipnetlab=CH Zurich Gassmann M, CH Zurich Lundby C, CH Zurich University of Zurich Physiology<br />
}}<br />
{{Labeling<br />
|area=Respiration, Exercise physiology;nutrition;life style<br />
|organism=Human<br />
|tissues=Skeletal muscle<br />
|preparations=Permeabilized tissue<br />
|couplingstates=OXPHOS, ETS<br />
|instruments=Oxygraph-2k<br />
}}</div>
Krumschnabel Gerhard