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Difference between revisions of "MiP2014"

From Bioblast
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|  [[Jana Prado F|Jana Prado Fabian]]||University of Chile, CL||
|  [[Jana Prado F|Jana Prado Fabian]]||University of Chile, CL||
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|  [[Kane DA| Kane Daniel A.]]||St. Francis Xavier University, Antigonish, CA||
|  [[Kane DA| Kane Daniel A.]]||St. Francis Xavier University, Antigonish, CA||Mitochondrial shuttles in muscle.
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|  [[Kraunsoe R|Kraunsoe Regitze]]||University of Copenhagen, DK||
|  [[Kraunsoe R|Kraunsoe Regitze]]||University of Copenhagen, DK||

Revision as of 12:21, 26 March 2014

IUBMB - International Union of Biochemistry and Molecular Biology
MiPsociety

MiP2014 - 10th MiPconference: Joint IUBMB/MiP Symposium on Mitochondrial Physiology - a Point/Counterpoint Meeting

International Union of Biochemistry and Molecular Biology and Mitochondrial Physiology Society

Obergurgl, Tyrol, Austria. 2014-Sep-08 to 12

MiP2014 - a point/counterpoint meeting

Mitochondrial research has recently undergone a dramatic renaissance, due to numerous discoveries revealing its central role in cell death, disease pathology, aging, thermogenesis, oxidative stress, cell signalling, cellular regulation and cell bioenergetics. The aim of the small symposium is to bring together experts in mitochondrial research spanning from the biochemical and molecular level to the interactions within the cell. In addition to the latest scientific findings, new methodological developments in measuring mitochondrial function and dysfunction are presented. A point/counterpoint format is chosen to discuss selected hot topics and some fundamental methodological and conceptual issues.

The expected attendance is max. 100 participants. ->> Compare MiP2013 Programme

Abstracts and presentations: refer to IUBMB nomenclature; >> MitoPedia Glossary: Respiratory states

Programme structure

In each of the 12 sessions a point/counterpoint introduction will be given by invited keynote speakers to provide a balanced overview and promote discussions. Short oral presentations are selected from abstracts, including student presentations. Rapid platform statements will introduce posters which contribute to a specific session. Posters are up throughout the meeting, and poster discussions are integrated into the platform sessions.

A. Mitochondrial respiratory control

  • A1. mtDNA, mt-phenotype and disease – is there biochemical and molecular-genetic evidence to explain observed associations?
  • A2. Fission and fusion, mitochondrial structure and function - is there a tight connection?
  • A3. Mitochondrial density and normalization of respiration – is there a general biochemical or molecular marker?
  • A4. Biochemical reserve capacity, respiratory control ratios and coupling efficiency – are conventional concepts inconsistent?

B. Experimental protocols in mitochondrial biochemistry

  • B1. Incubation media for mt-preparations and experimental temperature in functional studies of mammalian mitochondria – guided by concept or tradition?
  • B2. Intracellular oxygen pressure versus oxygen regimes in studies of ROS production and respiration - are mitochondria sources or sinks of ROS?
  • B3. Quantitative measurement of mt-membrane potential - potentiometric/fluorometric.
  • B4. Instrumental platforms in mitochondrial physiology – industrial presentations.

C. Towards quality assurance

  • C1. Do blood cells versus muscle biopsies provide valid models for diagnosis of mitochondrial pathologies?
  • C2. Integrity of mitochondrial preparations – is a consensus possible on quality control criteria?
  • C3. From availability and quality control of chemicals to mitochondrial respiratory protocols – who controls?
  • C4. Standards for the diagnosis of mitochondrial pathologies – a challenge for collaboration with mitochondrial organizations?

Particularly in view of Subtopic C, it may be attractive for mitochondrial organizations to send and support delegates. The conference will, therefore, provide a unique forum for international networking, and may inspire new national groups to be formed in contact with established mitochondrial organizations:

>> MitoGlobal_Organizations

MiP2014 preliminary participants

in progress
Name Institution Preliminary title
Ali Sameh S Zewail City for Science and Technology, ET Oxygen-consuming and ROS-producing activities in synaptosomes.
Bauer Christiane Maria OROBOROS INSTRUMENTS, Innsbruck, AT
Borutaite Vilmante Lithuanian University of Health Sciences, Kaunas, LT Controversies in testing integrity of mitochondrial membranes.
Brown David East Carolina University, NC, US
Contreras-Ferrat Ariel University of Chile, CL
Coen Paul Translational Research Institute for Metabolism and Diabetes, Orlando, FL, US
Dohlmann Tine University of Copenhagen, DK
Elmer Eskil Wallenberg Neuroscience Center, Lund, SE Ex vivo respiratory capacity of human blood cells - a SUITable application of the O2k Oxygraph / A novel pharmacological approach to counteract metabolic crisis.
Felding-Habermann Brunhilde The Scripps Research Institute, La Jolla, CA, US Mitochondrial functions in breast cancer progression.
Goodpaster Bret Translational Research Institute for Metabolism and Diabetes, Orlando, FL, US
Gnaiger Erich OROBOROS INSTRUMENTS, Innsbruck, AT
Hahn Dagmar Inselspital Bern, CH
Hand Steven C Louisiana State University, LA, US Integrity of mitochondrial preparations – is a consensus possible on quality control criteria?
Harrison David K OROBOROS INSTRUMENTS, Innsbruck, AT
Hepple Russel T. McGill University, Montreal, CA Mitochondrial involvement in aging muscle: cause and effect(or).
Hey-Mogensen Martin Novo Nordisk A/S Diabetes NBEs & Obesity Biology, Måløv, DK
Jana Prado Fabian University of Chile, CL
Kane Daniel A. St. Francis Xavier University, Antigonish, CA Mitochondrial shuttles in muscle.
Kraunsoe Regitze University of Copenhagen, DK
Koopman Werner J Radboud University Nijmegen Medical Centre, NL Redox regulation of mitochondrial dynamics.
Kowaltowski Alicia J. University of Sao Paulo, BR
Laner Verena OROBOROS INSTRUMENTS, Innsbruck, AT
Larsen Steen University of Copenhagen, DK Normalization of respiration.
Göran-Larsson Nils Max Planck Institute for the Biology of Ageing, Cologne, DE Mouse models with mtDNA mutations.
Ojuka Edward University of Cape Town, ZA Fission and fusion, mitochondrial structure and function - is there a tight connection?
Perry Christopher G York University, Ontario, CA Re-visiting critical experimental parameters to control when measuring respiratory kinetics in permeabilized muscle fibres.
Pesta Dominik Yale University School of Medicine, CT, US
Picard Martin University of Pennsylvania, PA, US Quantitative regulation of nuclear gene expression by mitochondrial DNA

heteroplasmy.

Pecina Petr Academy of Sciences of the Czech Republic, Prague, CZ The use of lymphocytes for diagnostics of mitochondrial disorders.
Purhonen Janne University Helsinki, FI
Ristow Michael ETH Zurich, CH Promoting health and lifespan by increasing mitochondrial ROS formation.
Shirihai Orian The Shirihai Lab at Boston University, MA, US
Skulachev Vladimir Lomonosov Moscow State University, Moscow, RU Mitochondria are sources of ROS rather than sinks: Physiological effects of mitochondria-targeted antioxidants.
Starkov Anatoly Weill Medical College Cornell University, NY, US
Stiban Johnny Birzeit University, Ramallah, PS Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis.
Zorzano Antonio Universitat de Barcelona, ES Metabolic implications of mitofusin 2 dysfunction.
Sumbalova Zuzana Comenius University, Bratislava, SK

Venue

The symposium will be hosted in the University Center in Obergurgl 100 km from Innsbruck. The closest airport is in Innsbruck. Participants arriving at Munich airport will take the train or an airport shuttle to Innsbruck. We provide support in arranging the transfer between Munich and Innsbruck. A bus transfer is organized between Innsbruck and Obergurgl.

The Obergurgl University Center is located at an altitude of 1940 meters above sea-level. The historical buildings, carefully refurbished and equipped with the latest technical systems, can accommodate around 70 persons in 43 bedrooms and includes conference rooms, the Alpine Research Center, laboratory, sports medicine, lounges and the restaurant. All rooms are equipped with an Internet connection. Additional participants are accommodated in smaller guest houses in 5 minutes walking distance. Meals are served for all participants in the University Center. Two conference rooms for a total of 200 persons and three small rooms for round table discussions are available. There is enough space for poster presentations and instrument exhibitions. The cosy bar and lounge area with an open fire place adds to the familiar atmosphere and supports the interactive spirit of the symposium.

The small village of Obergurgl is situated in an impressive landscape at about 1900 m above sea level in the Ötz valley. It is surrounded by mountains, offering an exceptional view to the Ötz valley glaciers. During summer time the area is famous for hiking and for skiing in winter time. On the doorstep: one of Europe´s finest Biosphere Parks. The unique surroundings offer the possibility of combining scientific discussions while exploring the alpine environment during the famous “walks and talks”. The informal atmosphere of the workshop encourages also students and young post-docs to participate actively in scientific discussions and to develop future collaborations.

University Centre Obergurgl, Gaisbergweg 5, 6456 Obergurgl, Tyrol, Austria.
Tel.: +43 (0) 512 507 37201 | Fax: +43 (0) 512 507 37400 | Email: [email protected] 

International programme committee

The international programme committee will provide scientific input by active participation, nominate further invited speakers to ensure balanced point/counterpoint introductions, and select the abstracts as a basis for participation (restricted number of participants), for oral 10+5 min presentations, and for flash presentations.

Chair:

Members:

Information for invited speakers

MiP2014 will be held at the University Centre Obergurgl, with maximum capacity of 124 persons and a price per person per night of € 65.- including a shared double room, breakfast, and dinner. MiPconferences are organized as small meetings facilitating communication between senior and junior participants. In the tradition of MiPconferences, we are asking invited speakers to cooperate and try to receive local support for joining us at the prestigious Mitochondrial Physiology Conference (limited to 124 participants). Support will be provided to students and young investigators.

Post-conference O2k-Workshop

A post-conference workshop is organized on the same venue, for hands-on training in mitochondrial respiratory physiology, introducing the combined measurement of high-resolution respirometry and fluorometry (OROBOROS INSTRUMENTS). Since participants come from all-over-the-world, including many students, the combination of the symposium with the workshop makes travelling more economical for the maximum of 24 workshop-participants. The post-conference workshop is financially completely separate from the symposium.

>> MitoGlobal_Events_2014