Metabolic control analysis

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Metabolic control analysis


Metabolic control analysis is a science focused on the understanding of metabolic regulation and control. In metabolism, the reductionist approach has allowed us to know which enzymes, metabolites and genes are involved in a metabolic pathway but this is not enough to understand how it is controlled, resulting in poor results from attempts to increase the rates of selected metabolic pathways. The control of the metabolism is the capacity to alter the metabolic state in response to an external signal. With this definition in mind, we will assess the metabolic control in terms of the strength of any of the responses to the external factor without making the assumption about the function or purpose of that response[1].


1. David Fell. Frontiers in metabolism 2. Understanding the control of metabolism. Portland Press. 1997.

Reference: Flux control efficiency

Communicated by Iglesias-Gonzalez J 2019-11-12.