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Laterveer 1996 FEBS Lett

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Laterveer FD, Nicolay K, Gellerich FN (1996) ADP delivery from adenylate kinase in the mitochondrial intermembrane space to oxidative phosphorylation increases in the presence of macromolecules. FEBS Lett 386:255-9.

ยป PMID: 8647294 Open Access

Laterveer FD, Nicolay K, Gellerich FN (1996) FEBS Lett

Abstract: Macromolecules were added to isolated rat liver mitochondria to mimic cytosolic macromolecules and tested for their effects on the ADP delivery from adenylate kinase in the intermembrane space to oxidative phosphorylation. In the presence of 10% (w/v) dextran M20 or bovine serum albumin, approximately 60% of the maximal ADP flux from adenylate kinase to oxidative phosphorylation was not accessible to an extramitochondrial ADP scavenger. In the absence of macromolecules this was 34%. ADP determinations from incubations with macromolecules demonstrated the existence of flux-dependent ADP concentration gradients across the outer membrane which can be as high as 12 ฮผM. โ€ข Keywords: Adenylate kinase, Macromolecule, Mitochondria, Rat liver, Intermembrane space, Oxidative phosphorylation, Compartmentation

โ€ข O2k-Network Lab: DE Magdeburg Gellerich FN, NL Eindhoven Nicolay K


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Organism: Rat  Tissue;cell: Liver  Preparation: Isolated mitochondria 

Regulation: ADP  Coupling state: OXPHOS 

HRR: Oxygraph-2k