Difference between revisions of "Laner 2017 Abstract EUROMIT2017 Cologne"
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{{Abstract | {{Abstract | ||
|title=[[Image:EUROMIT.jpg|left|100px|link=https://euromit2017.org/|EUROMIT2017]] | |title=[[Image:EUROMIT.jpg|left|100px|link=https://euromit2017.org/|EUROMIT2017]] | ||
[[MitoFit]] and [[MITOEAGLE]] β towards a global data bank on mitochondrial physiology. | |||
|info=[https://euromit2017.org EUROMIT2017] | |info=[https://euromit2017.org EUROMIT2017] | ||
|authors=Beno M, Doerrier C, Drinnan M, Garcia e Souza LF, Gnaiger E, Krumschnabel G, Laner V, Sumbalova Z, Velika B | |||
|year=2017 | |year=2017 | ||
|event=EUROMIT2017 Cologne DE | |event=EUROMIT2017 Cologne DE | ||
|abstract=A lack of physical activity associates with decreased mitochondrial capacity and is a major cause underlying metabolic dysregulation and preventable diseases in modern societies. In contrast, an active lifestyle supports enhanced mitochondrial capacities and reduces the risk of degenerative diseases. Despite this well-known relation between health and mitochondrial function, there is no regimented, quantitative system, or database organised to routinely test, compare and monitor mitochondrial capacities within individuals or populations. Every study of mitochondrial (mt) function and disease in human tissues and cells is faced with Evolution, Age, Gender, Lifestyle and Environment ([[EAGLE]]) as essential background conditions characterizing the individual patient, subject, study group, species, tissue or β to some extent - cell line. Only a large and well-coordinated network can manage to generate the necessary number of consistent data to address the complexity of EAGLE. Using [[high-resolution respirometry]], the [[MitoFit]] and [[MITOEAGLE]] initiatives develop novel lab standards and diagnostic methods for monitoring of a mitochondrial fitness score. SOPs are elaborated for sample preparation, respiratory evaluation and data documentation. Fresh and cryopreserved cells obtained non-invasively from blood samples broaden the scope for respirometric mitochondrial diagnosis. | |||
|editor=[[Kandolf G]] | |||
|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck OROBOROS | |||
}} | |||
{{Labeling | |||
|area=Respiration, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style, mt-Medicine, mt-Awareness | |||
|diseases=Aging;senescence | |||
|injuries=Mitochondrial disease | |||
|organism=Human | |||
|instruments=Oxygraph-2k | |||
}} | }} | ||
== Affiliations == | == Affiliations == | ||
:::: Beno M(1), Doerrier C(1), Drinnan M(2), Garcia e Souza LF(3), Gnaiger E(1,2), Krumschnabel G(1), Laner V(1), Sumbalova Z(2), Velika B(2,4) | :::: Beno M(1), Doerrier C(1), Drinnan M(2), Garcia e Souza LF(3), Gnaiger E(1,2), Krumschnabel G(1), Laner V(1), Sumbalova Z(2), Velika B(2,4) | ||
| Line 16: | Line 27: | ||
== Support == | == Support == | ||
:::: Contribution to: K-Regio project MitoFit, funded by the Land Tirol, Austria, and COST Action 15203 MITOEAGLE. | :::: Contribution to: [[K-Regio project MitoFit]], funded by the Land Tirol, Austria, and [[COST Action 15203 MITOEAGLE|COST Action 15203 MITOEAGLE]]. | ||
Revision as of 13:56, 12 April 2017
 MitoFit and MITOEAGLE β towards a global data bank on mitochondrial physiology. |
Link: EUROMIT2017
Beno M, Doerrier C, Drinnan M, Garcia e Souza LF, Gnaiger E, Krumschnabel G, Laner V, Sumbalova Z, Velika B (2017)
Event: EUROMIT2017 Cologne DE
A lack of physical activity associates with decreased mitochondrial capacity and is a major cause underlying metabolic dysregulation and preventable diseases in modern societies. In contrast, an active lifestyle supports enhanced mitochondrial capacities and reduces the risk of degenerative diseases. Despite this well-known relation between health and mitochondrial function, there is no regimented, quantitative system, or database organised to routinely test, compare and monitor mitochondrial capacities within individuals or populations. Every study of mitochondrial (mt) function and disease in human tissues and cells is faced with Evolution, Age, Gender, Lifestyle and Environment (EAGLE) as essential background conditions characterizing the individual patient, subject, study group, species, tissue or β to some extent - cell line. Only a large and well-coordinated network can manage to generate the necessary number of consistent data to address the complexity of EAGLE. Using high-resolution respirometry, the MitoFit and MITOEAGLE initiatives develop novel lab standards and diagnostic methods for monitoring of a mitochondrial fitness score. SOPs are elaborated for sample preparation, respiratory evaluation and data documentation. Fresh and cryopreserved cells obtained non-invasively from blood samples broaden the scope for respirometric mitochondrial diagnosis.
β’ Bioblast editor: Kandolf G
β’ O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck OROBOROS
Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style, mt-Medicine, mt-Awareness Pathology: Aging;senescence Stress:Mitochondrial disease Organism: Human
HRR: Oxygraph-2k
Affiliations
- Beno M(1), Doerrier C(1), Drinnan M(2), Garcia e Souza LF(3), Gnaiger E(1,2), Krumschnabel G(1), Laner V(1), Sumbalova Z(2), Velika B(2,4)
- OROBOROS INSTRUMENTS, Innsbruck, Austria. - [email protected]
- Medical Univ Innsbruck, Austria
- Leopold-Franzens Univ Innsbruck, Austria
- Pavol Jozef Ε afΓ‘rik Univ Kosice, Slovakia
Support
- Contribution to: K-Regio project MitoFit, funded by the Land Tirol, Austria, and COST Action 15203 MITOEAGLE.
