Difference between revisions of "LEAK state without adenylates"

Revision as of 16:49, 25 February 2011

high-resolution terminology - matching measurements at high-resolution

LEAK state without adenylates

Description

In the LEAK state without adenylates, L_N (N for no adenylates), mitochondrial respiration is measured after addition of substrates, which decreases slowly to the LEAK state after oxidation of endogenous substrates with no adenylates.

Abbreviation: L_N

Reference: MiPNet12.15; List of respiratory states

Labels:

Regulation: Respiratory state"Respiratory state" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., ATP; ADP; AMP; PCr"ATP; ADP; AMP; PCr" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.

HRR: Theory

State 2

State 2 was re-defined as functionally the same as State 4 (Nicholls and Ferguson 2002). State 2 (Chance and Williams 1955, 1956), however, is substrate-limited residual oxygen consumption at high ADP (ROX_D), whereas L_N and L_T (State 4) are LEAK states in the absence of adenylates (L_N: no ADP, no ATP) or presence of ATP (L_T).

@@ Line 1: / Line 1: @@
 {{MitoPedia
 |abbr=''L''<sub>N</sub>
-|description='''LEAK state without adenylates''' or [[State 2']].
+|description=In the '''LEAK state without adenylates''', ''L''<sub>N</sub> (N for no adenylates), mitochondrial respiration is measured after addition of substrates, which decreases slowly to the [[LEAK state]] after oxidation of endogenous substrates with no [[adenylate|adenylates]].
-Respiration after addition of substrates, which decreases slowly to the [[LEAK state]] after oxidation of endogenous substrates with no [[adenylate|adenylates]] (L<sub>N</sub>); [[State 2']].  [[State 2]] was re-defined as functionally the same as [[State 4]] (Nicholls and Ferguson 2002), with reference to Chance and Williams (1956).  State 2 (Chance and Williams 1955, 1956), however, is substrate-limited residual oxygen consumption at high ADP (ROXD), whereas State 2' (L<sub>N</sub>) and State 4 (''L''<sub>T</sub>) are LEAK states in the absence of adenylates (''L''<sub>N</sub>: no ADP, no ATP) or presence of ATP (''L''<sub>T</sub>).
 |info=[[MiPNet12.15]];  [[List:_Respiratory_states|List of respiratory states]]
 |type=Respiration
@@ Line 12: / Line 11: @@
 |type=Respiration
 }}
+==State 2==
+[[State 2]] was re-defined as functionally the same as [[State 4]] (Nicholls and Ferguson 2002). State 2 (Chance and Williams 1955, 1956), however, is substrate-limited residual oxygen consumption at high ADP (ROX<sub>D</sub>), whereas ''L''<sub>N</sub> and ''L''<sub>T</sub> (State 4) are LEAK states in the absence of adenylates (''L''<sub>N</sub>: no ADP, no ATP) or presence of ATP (''L''<sub>T</sub>).