Difference between revisions of "Kosenko 2010 Biology Bull"
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|abstract=The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with | |abstract=The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with | ||
succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. | succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. | ||
|keywords=hypoxen (Oliphen, Moscow) | |keywords=hypoxen (Oliphen, Moscow), | ||
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{{Labeling | {{Labeling | ||
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|tissues=Hepatocyte; Liver | |tissues=Hepatocyte; Liver | ||
|preparations=Isolated Mitochondria | |preparations=Isolated Mitochondria | ||
|additional=Pharmacology; Biotechnology | |||
}} | }} | ||
Revision as of 16:03, 17 November 2011
| Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull. 37: 346-350. |
» PMID:
Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) Biology Bull.
Abstract: The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. • Keywords: hypoxen (Oliphen, Moscow)
Labels:
Organism: Rat
Tissue;cell: Hepatocyte; Liver"Hepatocyte; Liver" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property.
Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
HRR: Oxygraph-2k
Pharmacology; Biotechnology
