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Difference between revisions of "Hafstad 2011 J Appl Physiol"

From Bioblast
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|instruments=Oxygraph-2k
|instruments=Oxygraph-2k
|organism=Mouse
|organism=Mouse
|tissues=Cardiac muscle
|tissues=Heart
|couplingstates=OXPHOS
|couplingstates=OXPHOS
|topics=Mitochondrial Biogenesis; Mitochondrial Density, Substrate; Glucose; TCA Cycle
|topics=Mitochondrial Biogenesis; Mitochondrial Density, Substrate; Glucose; TCA Cycle
}}
}}

Revision as of 10:34, 27 February 2013

Publications in the MiPMap
Hafstad AD, Boardman NT, Lund J, Hagve M, Khalid AM, Wislรธff U, Larsen TS, Aasum E (2011) High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart. J Appl Physiol 111: 1235-1241.

ยป PMID: 21836050

Hafstad AD, Boardman NT, Lund J, Hagve M, Khalid AM, Wisloeff U, Larsen TS, Aasum E (2011) J Appl Physiol

Abstract: AIMS: Although exercise training induces hypertrophy with improved contractile function, the effect of exercise on myocardial substrate metabolism and cardiac efficiency is less clear. High intensity training has been shown to produce more profound effects on cardiovascular function and aerobic capacity than isocaloric low and moderate intensity training. The aim of the present study was to explore metabolic and mechanoenergetic changes in the heart following endurance exercise training of both high and moderate intensity.

METHODS AND RESULTS: C57BL/6J mice were subjected to 10 wk treadmill running, either high intensity interval training (HIT) or distance-matched moderate intensity training (MIT), where HIT led to a pronounced increase in maximal oxygen uptake. Although both modes of exercise were associated with a 10% increase in heart weight-to-body weight ratio, only HIT altered cardiac substrate utilization, as revealed by a 36% increase in glucose oxidation and a concomitant reduction in fatty acid oxidation. HIT also improved cardiac efficiency by decreasing work-independent myocardial oxygen consumption. In addition, it increased cardiac maximal mitochondrial respiratory capacity.

CONCLUSION: This study shows that high intensity training is required for induction of changes in cardiac substrate utilization and energetics, which may contribute to the superior effects of high compared with moderate intensity training in terms of increasing aerobic capacity. โ€ข Keywords: Exercise training

โ€ข O2k-Network Lab: NO Tromso Larsen TS


Labels:


Organism: Mouse  Tissue;cell: Heart 


Regulation: Mitochondrial Biogenesis; Mitochondrial Density"Mitochondrial Biogenesis; Mitochondrial Density" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.  Coupling state: OXPHOS 

HRR: Oxygraph-2k