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Difference between revisions of "Gnaiger 2000 Transplant Proc"

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{{Publication
{{Publication
|title=Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant. Proc. 32: 14.
|title=Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant. Proc. 32: 14.
|info=[http://www.ncbi.nlm.nih.gov/pubmed/10700947 PMID: 10700947]
|authors=Gnaiger E, Kuznetsov AV, Koenigsrainer A, Margreiter R
|authors=Gnaiger E, Kuznetsov AV, Koenigsrainer A, Margreiter R
|year=2000
|year=2000
|journal=Transplant. Proc.
|journal=Transplant. Proc.
|abstract=AUTOOXIDATION reactions of highly reduced organic compounds are a source of reactive oxygen species that contribute to ischemia/reperfusion injury. Antioxidants such as reduced glutathione (GSH; g-glutamylcysteinylglycine) are added to organ preservation solutions to reduce oxidative stress.<sup>1,2</sup> GSH is unstable, however, in University of Wisconsin (UW) solution in the presence of oxygen.<sup>3</sup> To our knowledge, no reports are available on the stability of GSH in other organ preservation solutions, such as histidine-tryptophan-ketoglutarate (HTK) or Celsior solution. The present study reports for the first time a quantitative comparison of autooxidation of GSH in a variety of established preservation solutions, demonstrating in particular the high stability of GSH in HTK solution.
|mipnetlab=AT_Innsbruck_Gnaiger E
|mipnetlab=AT_Innsbruck_Gnaiger E
|abstract=AUTOOXIDATION reactions of highly reduced organic compounds are a source of reactive oxygen species that contribute to ischemia/reperfusion injury. Antioxidants such as reduced glutathione (GSH; g-glutamylcysteinylglycine) are added to organ preservation solutions to reduce oxidative stress.<sup>1,2</sup> GSH is unstable, however, in University of Wisconsin (UW) solution in the presence of oxygen.<sup>3</sup> To our knowledge, no reports are available on the stability of GSH in other organ preservation solutions, such as histidine-tryptophan-ketoglutarate (HTK) or Celsior solution. The present study reports for the first time a quantitative comparison of autooxidation of GSH in a variety of established preservation solutions, demonstrating in particular the high stability of GSH in HTK solution.
|discipline=Biomedicine, Pharmacology; Biotechnology
|info=[http://www.ncbi.nlm.nih.gov/pubmed/10700947 PMID: 10700947]
}}
}}
{{Labeling
{{Labeling
|instruments=Oxygraph-2k
|instruments=Oxygraph-2k
|discipline=Biomedicine, Pharmacology; Biotechnology
|injuries=Ischemia-Reperfusion; Preservation
|preparations=Oxidase; Biochemical Oxidation
|preparations=Oxidase; Biochemical Oxidation
|injuries=Ischemia-Reperfusion; Preservation
|kinetics=Oxygen, Temperature, pH
|kinetics=Oxygen, Temperature, pH
|additional=Pharmacology; Biotechnology
|discipline=Biomedicine, Pharmacology; Biotechnology
}}
}}

Revision as of 15:04, 17 November 2011

Publications in the MiPMap
Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant. Proc. 32: 14.

» PMID: 10700947

Gnaiger E, Kuznetsov AV, Koenigsrainer A, Margreiter R (2000) Transplant. Proc.

Abstract: AUTOOXIDATION reactions of highly reduced organic compounds are a source of reactive oxygen species that contribute to ischemia/reperfusion injury. Antioxidants such as reduced glutathione (GSH; g-glutamylcysteinylglycine) are added to organ preservation solutions to reduce oxidative stress.1,2 GSH is unstable, however, in University of Wisconsin (UW) solution in the presence of oxygen.3 To our knowledge, no reports are available on the stability of GSH in other organ preservation solutions, such as histidine-tryptophan-ketoglutarate (HTK) or Celsior solution. The present study reports for the first time a quantitative comparison of autooxidation of GSH in a variety of established preservation solutions, demonstrating in particular the high stability of GSH in HTK solution.


O2k-Network Lab: AT_Innsbruck_Gnaiger E


Labels:

Stress:Ischemia-Reperfusion; Preservation"Ischemia-Reperfusion; Preservation" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property. 


Preparation: Oxidase; Biochemical Oxidation"Oxidase; Biochemical Oxidation" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property. 



HRR: Oxygraph-2k 

Pharmacology; Biotechnology