Difference between revisions of "Glycerophosphate pathway control state"
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|abbr=Gp | |abbr=Gp | ||
|description=[[File:Gp-shuttle.jpg|left|200px|Gp]] '''Gp''': The glycero-phosphate shuttle represents an important pathway, particularly in liver, of making cytoplasmic [[NADH]] available for mitochondrial [[oxidative phosphorylation]]. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer system at the level of [[CoQ]]. | |description=[[File:Gp-shuttle.jpg|left|200px|Gp]] '''Gp''': The glycero-phosphate shuttle represents an important pathway, particularly in liver, of making cytoplasmic [[NADH]] available for mitochondrial [[oxidative phosphorylation]]. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer system at the level of [[CoQ]]. | ||
|info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 4.4]] | |info=[[Pathway control state]], [[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 4.4]] | ||
}} | }} | ||
{{MitoPedia concepts | {{MitoPedia concepts | ||
|mitopedia concept=Respiratory state, SUIT state | |mitopedia concept=Respiratory state, SUIT state | ||
}} | }} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Substrate and metabolite | |mitopedia topic=Substrate and metabolite | ||
Revision as of 13:50, 9 November 2016
- high-resolution terminology - matching measurements at high-resolution
Glycerophosphate pathway control state
Description
Gp: The glycero-phosphate shuttle represents an important pathway, particularly in liver, of making cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer system at the level of CoQ.
Abbreviation: Gp
Reference: Pathway control state, Gnaiger 2014 MitoPathways - Chapter 4.4
MitoPedia concepts:
Respiratory state,
SUIT state
MitoPedia topics:
Substrate and metabolite
Gp(L)
Gp(P)
Gp(E)
Details
- Glycerophosphate oxidation is 10-fold higher in rabbit gracilis mitochondria (fast-twitch white muscle; 99% type IIb) compared to soleus (slow-twitch red muscle; 98% type I). Activity is comparatively low in human vastus lateralis. Glycerophosphate is an important substrate for respiration in brown adipose tissue mitochondria.
