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Difference between revisions of "Garratt 2014 Proc Natl Acad Sci U S A"

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{{Publication
{{Publication
|title=Garratt M, Pichaud N, Glaros EN, Kee AJ, Brooks RC (2014) Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice. Proc Natl Acad Sci U S A [Epub ahead of print]. ย 
|title=Garratt M, Pichaud N, Glaros EN, Kee AJ, Brooks RC (2014) Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice. Proc Natl Acad Sci U S A 111:8119-24.
|info=[http://www.ncbi.nlm.nih.gov/pubmed/24843175 PMID: 24843175]
|info=[http://www.ncbi.nlm.nih.gov/pubmed/24843175 PMID: 24843175]
|authors=Garratt M, Pichaud N, Glaros EN, Kee AJ, Brooks RC
|authors=Garratt M, Pichaud N, Glaros EN, Kee AJ, Brooks RC
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|tissues=Liver
|tissues=Liver
|preparations=Permeabilized tissue
|preparations=Permeabilized tissue
|couplingstates=LEAK, OXPHOS, ETS
|couplingstates=LEAK, OXPHOS, ET
|substratestates=CI, CII, ETF, CIV, CI+II, ROX
|pathways=F, N, S, CIV, NS, ROX
|instruments=Oxygraph-2k
|instruments=Oxygraph-2k
}}
}}

Latest revision as of 13:18, 13 November 2017

Publications in the MiPMap
Garratt M, Pichaud N, Glaros EN, Kee AJ, Brooks RC (2014) Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice. Proc Natl Acad Sci U S A 111:8119-24.

ยป PMID: 24843175

Garratt M, Pichaud N, Glaros EN, Kee AJ, Brooks RC (2014) Proc Natl Acad Sci U S A

Abstract: Oxidative stress (an overproduction of reactive oxygen species in relation to defense mechanisms) may restrict investment in life history traits, such as growth, reproduction, lifespan, and the production of sexual signals to attract mates. The constraint on sexual signaling by oxidative stress is of particular interest because it has been proposed as a mechanism ensuring that only good-quality males produce the most attractive sexual signals. Despite these predictions, evidence supporting this theory is, at best, equivocal. We used a superoxide dismutase knockout mouse to demonstrate that oxidative stress directly impairs investment in morphological (preputial glands) and molecular (major urinary proteins) components of olfactory signaling essential for mate attraction. By maintaining males in a much more competitive environment than usual for mouse laboratory experiments, we also revealed a range of phenotypes of superoxide dismutase deficiency not observed in previous studies of this mouse model. This range included impaired bioenergetic function, which was undetectable in the control environment of this study. We urge further examination of model organisms in seminatural conditions and more competitive laboratory environments, as important phenotypes can be exposed under these more demanding conditions. โ€ข Keywords: Ssexual selection, Condition dependence, Antioxidant, Maleโ€“male competition, Sod1

โ€ข O2k-Network Lab: AU Sydney Ballard JW


Labels: MiParea: Respiration 


Organism: Mouse  Tissue;cell: Liver  Preparation: Permeabilized tissue 


Coupling state: LEAK, OXPHOS, ET  Pathway: F, N, S, CIV, NS, ROX  HRR: Oxygraph-2k