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Description
Bendavia (Elamipretide) was developed as a mitochondria-targeted drug against degenerative diseases, including cardiac ischemia-reperfusion injury. Clinical trials showed variable results. It is a cationic tetrapeptide which readily passes cell membranes, associates with cardiolipin in the mitochondrial inner membrane. Supercomplex-associated CIV activity significantly improved in response to elamipretide treatment in the failing human heart.
Abbreviation: Bendavia
Reference: Chatfield 2019 JACC Basic Transl Sci
Elamipretide and mitObesity
Work in progress by Gnaiger E 2020-02-12 linked to a preprint in preparation on mitObesity drugs.
References: Bendavia (Elamipretide)
Year | Reference | Organism | Tissue;cell | Pathology | |
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Chatfield 2019 JACC Basic Transl Sci | 2019 | Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57. | Human | Heart | Cardiovascular |
Campbell 2018 Free Radic Biol Med | 2018 | Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, Qian WJ, Marcinek DJ (2018) Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med 134:268-81. | Mouse | Skeletal muscle | Aging;senescence |
Brown 2014 J Cardiovasc Pharmacol Ther | 2014 | Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA (2014) Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther 19:121-32. | Rat | Heart |
Year | Reference | Organism | Tissue;cell | Pathology | |
---|---|---|---|---|---|
Bamberger 2018 MiP2018 | 2018 | Discovery and development of elamipretide: targeting mitochondrial dysfunction in rare and common disease. | |||
Marcinek 2016 Abstract MitoFit Science Camp 2016 | 2016 | Targeting mitochondrial redox stress reveals two phases for reversal of mitochondrial dysfunction in aged mouse skeletal muscle. | Mouse | Skeletal muscle | Aging;senescence |
Shaikh 2014 Circulation | 2014 | Shaikh SR, Moukdar F, Alleman RJ, Lark DS, Neufer PD, Brown D (2014) The cardiolipin-targeting peptide Bendavia improves post-ischemic mitochondrial energetics by sustaining native respiratory protein complexes. Am Heart Assoc 130:A17592. | Rat | Heart |
MitoPedia: mitObesity drugs
Healthy reference population | Body mass excess | BFE | BME cutoffs | BMI | H | M | VO2max | mitObesity drugs |
MitoPedia concepts:
MiP concept
Labels:
MitoPedia:mitObesity drug