Ebanks 2022 Abstract Bioblast
P09.  |
Link: Bioblast 2022: BEC Inaugural Conference
Ebanks Brad, Wang Y, Katyal G, Sargent C, Ingram TL, Bowman A, Moisoi Nicoleta, Chakrabarti Lisa (2022)
Event: Bioblast 2022
Biological ageing is one of the biggest risk factors for a range of diseases, including cancers, neurodegenerative disease, and heart disease. Mitochondrial dysfunction is associated with both ageing and diseases of ageing. As exercise is increasingly being viewed as a potential anti-ageing therapy, we sought to assess the impact of exercise on the fitness and lifespan of D. melanogaster[1]. In addition, we assessed the exercise-induced changes to mitochondrial physiology through high-resolution respirometry and label-free mass spectrometry. Exercise in late life extends the lifespan of male and female D. melanogaster compared with those exercised throughout their entire lifetime. Exercise also increases Complex-II-linked respiration and upregulates the expression of proteins from the electron transfer Complexes I, III, IV.
- Ebanks B, Wang Y, Katyal G, Sargent C, Ingram TL, Bowman A, Moisoi N, Chakrabarti L (2021) Exercising D. melanogaster modulates the mitochondrial proteome and physiology. The effect on lifespan depends upon age and sex. https://doi.org/10.3390/ijms222111606
• Keywords: Drosophila; ageing; exercise; lifespan; mitochondria; proteomics; respirometry
Affiliation
- University of Nottingham, UK - [email protected]
List of abbreviations, terms and definitions - MitoPedia
Labels: MiParea: Exercise physiology;nutrition;life style
Pathology: Aging;senescence
Organism: Drosophila
HRR: Oxygraph-2k
Event: Poster
