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Difference between revisions of "Ebanks 2022 Abstract Bioblast"

From Bioblast
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{{Abstract
{{Abstract
|title=<u>Ebanks Brad</u> (2022) Exercise alters mitochondrial physiology and has age-specific impacts on the fitness and lifespan of ''D. melanogaster''. Bioblast 2022: BEC Inaugural Conference.
|title=<u>Ebanks Brad</u> (2022) Exercise alters mitochondrial physiology and has age-specific impacts on the fitness and lifespan of ''D. melanogaster''. Bioblast 2022: BEC Inaugural Conference.
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|year=2022
|year=2022
|event=[[Bioblast 2022]]
|event=[[Bioblast 2022]]
|abstract=
|abstract=Biological ageing is one of the biggest risk factors for a range of diseases, including cancers, neurodegenerative disease, and heart disease. Mitochondrial dysfunction is associated with both ageing and diseases of ageing. As exercise is increasingly being viewed as a potential anti-ageing therapy, we sought to assess the impact of exercise on the fitness and lifespan of ''D. melanogaster''[1]. In addition, we assessed the exercise-induced changes to mitochondrial physiology through high-resolution respirometry and label-free mass spectrometry. Exercise in late life extends the lifespan of male and female ''D. melanogaster'' compared with those exercised throughout their entire lifetime. Exercise also increases Complex-II-linked respiration and upregulates the expression of proteins from the electron transfer Complexes I, III, IV.
Β  Β  Β  Β  Β  Biological ageing is one of the biggest risk factors for a range of diseases, including cancers, neurodegenerative disease, and heart disease. Mitochondrial dysfunction is associated with both ageing and diseases of ageing. As exercise is increasingly being viewed as a potential anti-ageing therapy, we sought to assess the impact of exercise on the fitness and lifespan of ''D. melanogaster''[1]. In addition, we assessed the exercise-induced changes to mitochondrial physiology through high-resolution respirometry and label-free mass spectrometry. Exercise in late life extends the lifespan of male and female ''D. melanogaster'' compared with those exercised throughout their entire lifetime. Exercise also increases Complex-II-linked respiration and upregulates the expression of proteins from the electron transfer Complexes I, III, IV.
|keywords=Drosophila; ageing; exercise; lifespan; mitochondria; proteomics; respirometry
|keywords=Drosophila; ageing; exercise; lifespan; mitochondria; proteomics; respirometry
|editor=
}}
{{Labeling
|area=Exercise physiology;nutrition;life style
|diseases=Aging;senescence
|organism=Drosophila
|instruments=Oxygraph-2k
|articletype=Abstract
}}
[[File:Bioblast2022 banner.jpg|link=Bioblast_2022]]


|mipnetlab=
}}
== Affiliations ==
== Affiliations ==
::::University of Nottingham, UK - [email protected]
::::University of Nottingham, UK - [email protected]
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== List of abbreviations, terms and definitions - MitoPedia ==
== List of abbreviations, terms and definitions - MitoPedia ==
{{Template:List of abbreviations, terms and definitions - MitoPedia}}
{{Template:List of abbreviations, terms and definitions - MitoPedia}}
{{Labeling
|area= Exercise physiology;nutrition;life style
|diseases=
|organism=
|tissues=
|instruments=Oxygraph-2k
|articletype=Abstract
}}

Revision as of 13:31, 31 May 2022

Ebanks Brad (2022) Exercise alters mitochondrial physiology and has age-specific impacts on the fitness and lifespan of D. melanogaster. Bioblast 2022: BEC Inaugural Conference.

Link: Bioblast 2022: BEC Inaugural Conference

Ebanks Brad (2022)

Event: Bioblast 2022

Biological ageing is one of the biggest risk factors for a range of diseases, including cancers, neurodegenerative disease, and heart disease. Mitochondrial dysfunction is associated with both ageing and diseases of ageing. As exercise is increasingly being viewed as a potential anti-ageing therapy, we sought to assess the impact of exercise on the fitness and lifespan of D. melanogaster[1]. In addition, we assessed the exercise-induced changes to mitochondrial physiology through high-resolution respirometry and label-free mass spectrometry. Exercise in late life extends the lifespan of male and female D. melanogaster compared with those exercised throughout their entire lifetime. Exercise also increases Complex-II-linked respiration and upregulates the expression of proteins from the electron transfer Complexes I, III, IV.

β€’ Keywords: Drosophila; ageing; exercise; lifespan; mitochondria; proteomics; respirometry


Labels: MiParea: Exercise physiology;nutrition;life style  Pathology: Aging;senescence 

Organism: Drosophila 




HRR: Oxygraph-2k 


Bioblast2022 banner.jpg

Affiliations

University of Nottingham, UK - [email protected]

References

  1. Ebanks, B. et al (2021) Exercising D. melanogaster modulates the mitochondrial proteome and physiology. The effect on lifespan depends upon age and sex. Int. J. Mol. Sci. 22: 11606. doi:10.3390/ijms222111606

List of abbreviations, terms and definitions - MitoPedia

Β» MitoPedia: Terms and abbreviations