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Difference between revisions of "E-L coupling efficiency"

From Bioblast
Line 39: Line 39:
* [[Coupling control factor]]
* [[Coupling control factor]]
* [[E-L coupling control factor]]
* [[E-L coupling control factor]]
* [[Excess ETS capacity factor over P |Excess ETS capacity factor over ''P'']], excess ''E-P'' capacity factor, ''E-P'' coupling control factor
* [[ETS excess capacity factor over P |ETS excess capacity factor over ''P'']], excess ''E-P'' capacity factor, ''E-P'' coupling control factor
* [[E-R coupling control factor]]
* [[E-R coupling control factor]]



Revision as of 17:02, 21 September 2014


high-resolution terminology - matching measurements at high-resolution


E-L coupling efficiency

Description

The ETS coupling efficiency is a normalized flux ratio ('biochemical coupling efficiency') or E-L coupling control factor, j≈E = ≈E/E = (E-L)/E = 1-L/E. j≈E is 0.0 at zero coupling (L=E) and 1.0 at the limit of a fully coupled system (L=0). The LEAK state is stimulated to ETS by uncoupler titration. LEAK states LN or LT may be stimulated first by saturating ADP (state P) with subsequent uncoupler titration to state E. The ETS coupling efficiency is based on measurement of the coupling control ratio, L/E, whereas the thermodynamic or ergodynamic efficiency of coupling between ATP production (DT phosphorylation) and oxygen consumption is based on measurement of the output/input flux ratio (~P/O2 ratio) and output/input force ratio (Gibbs force of phosphorylation/Gibbs force of oxidation). » MiPNet article

Abbreviation: j≈E

Reference: Flux control factor


MitoPedia methods: Respirometry 


MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. 

Biochemical coupling efficiency: from 0 to <1

Publications in the MiPMap
Gnaiger E (2014) Biochemical coupling efficiency: from 0 to <1. Mitochondr Physiol Network 2014-04-18.


OROBOROS (2014) MiPNet

Abstract: Zooming in on biochemical coupling efficiency.


O2k-Network Lab: AT Innsbruck Gnaiger E


Labels:




Regulation: Coupling efficiency;uncoupling  Coupling state: LEAK, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property. 

HRR: Theory 


Related terms in MitoPedia

Efficiency


Coupling

  • Is respiration uncoupled - noncoupled - dyscoupled? [3]

Coupling control factors

Coupling control ratios

Relevant respiratory states

Basics

References

  1. Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65: 1983-2002. »Open Access
  2. Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving Hypoxia: Mechanisms of Control and Adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo: 77-109. »Bioblast Access
  3. Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »Uncoupler
  4. Gnaiger E (2012) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 3rd ed. Mitochondr Physiol Network 17.18. OROBOROS MiPNet Publications, Innsbruck: 64 pp. »Open Access


List of publications: ETS and LEAK