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E-R control efficiency

From Bioblast


high-resolution terminology - matching measurements at high-resolution


E-R control efficiency

Description

Excess E-R capacity factor The apparent excess E-R capacity factor (E-R coupling control factor), jExR = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in intact cells by uncoupling. jExR = 0.0 for zero excess capacity when R=E; jExR = 1.0 for the maximum limit when R=0. The ROUTINE state of intact cells is stimulated to ETS by uncoupler titration, which yields the excess E-R capacity, ExR=E-R. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), ExR or jExR is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent excess E-P capacity, ExP=E-P, is not a respiratory reserve in the sense of oxidative phosphorylation.

Abbreviation: jExR

Reference: Flux control factor


MitoPedia methods: Respirometry 


MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. 

Compare

Β» ROUTINE control ratio, R/E
Β» Excess E-P capacity factor, jExP = (E-P)/E = 1-P/E
Β» ETS coupling efficiency, jβ‰ˆE = 1-L/E