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E-R control efficiency
Description
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The apparent ET-reserve coupling efficiency (E-R coupling control efficiency), jE-R = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in living cells by uncoupling. jE-R = 0.0 for zero excess capacity when R=E; jE-R = 1.0 for the maximum limit when R=0. The ROUTINE state of living cells is stimulated to Electron transfer pathway by uncoupler titration, which yields the excess E-R capacity, E-R. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), ExR or jExR is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent excess E-P capacity, E-P, is not a respiratory reserve in the sense of oxidative phosphorylation.
Abbreviation: jExR
Reference: Flux control efficiency
Compare
- » ROUTINE-control ratio, R/E
- » ET-excess coupling efficiency, jE-P = (E-P)/E = 1-P/E
- » ET-coupling efficiency, jE-L = 1-L/E
MitoPedia concepts: Respiratory control ratio
