Difference between revisions of "E-R control efficiency"

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E-R control efficiency

Description

The apparent ETS excess factor over R (E-R coupling control factor), Ex_R/E = (E-R)/E, is an expression of the relative scope of increasing ROUTINE respiration in intact cells by uncoupling. Ex_R/E = 0.0 for zero excess capacity when R=E; Ex_R/E = 1.0 for the maximum limit when R=0. The ROUTINE state of intact cells is stimulated to ETS by uncoupler titration. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), E-R or Ex_R/E is not a reseve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration.

Abbreviation: Ex_R/E

Reference: Flux control factor

MitoPedia methods: Respirometry

MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.

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ETS excess factor over P
More details: Biochemical coupling efficiency

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 {{MitoPedia
 |abbr=''Ex<sub>R</sub>/E''
-|description=The apparent '''ETS excess factor over ''R''''' (''E-R'' coupling control factor), ''Ex<sub>R</sub>/E'' = (''E-R'')/''E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] by uncoupling. ''Ex<sub>R</sub>/E'' = 0.0 for zero excess capacity when ''R''=''E''; ''Ex<sub>R</sub>/E'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of intact cells is stimulated to [[ETS]] by [[uncoupler]] titration.
+|description=The apparent '''ETS excess factor over ''R''''' (''E-R'' coupling control factor), ''Ex<sub>R</sub>/E'' = (''E-R'')/''E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in intact cells by uncoupling. ''Ex<sub>R</sub>/E'' = 0.0 for zero excess capacity when ''R''=''E''; ''Ex<sub>R</sub>/E'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of intact cells is stimulated to [[ETS]] by [[uncoupler]] titration. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''''[[cell ergometry]]'''''), ''E-R'' or ''Ex<sub>R</sub>/E'' is not a reseve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration.
 |info=[[Flux control factor]]
 }}