Difference between revisions of "E-R control efficiency"
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|abbr=''j<sub>ExR</sub>'' | |abbr=''j<sub>ExR</sub>'' | ||
|description=The apparent '''excess ''E-R'' capacity factor (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in intact cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of intact cells is stimulated to [[ETS]] by [[uncoupler]] titration. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by | |description=The apparent '''excess ''E-R'' capacity factor''' (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in intact cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of intact cells is stimulated to [[ETS]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''ExR''=''E-R''. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation. | ||
|info=[[Flux control factor]] | |info=[[Flux control factor]] | ||
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== Compare == | == Compare == | ||
:::» [[Excess E-P capacity factor |Excess ''E-P'' capacity factor]], ''j<sub>ExP</sub>'' = (''E-P'')/''E'' = 1-''P/E'' | |||
:::» [[ETS coupling efficiency]], ''j<sub>≈E</sub>'' = 1-''L/E'' | |||
Revision as of 13:37, 15 January 2015
- high-resolution terminology - matching measurements at high-resolution
E-R control efficiency
Description
The apparent excess E-R capacity factor (E-R coupling control factor), jExR = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in intact cells by uncoupling. jExR = 0.0 for zero excess capacity when R=E; jExR = 1.0 for the maximum limit when R=0. The ROUTINE state of intact cells is stimulated to ETS by uncoupler titration, which yields the excess E-R capacity, ExR=E-R. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), ExR or jExR is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent excess E-P capacity, ExP=E-P, is not a respiratory reserve in the sense of oxidative phosphorylation.
Abbreviation: jExR
Reference: Flux control factor
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Compare
- » Excess E-P capacity factor, jExP = (E-P)/E = 1-P/E
- » ETS coupling efficiency, j≈E = 1-L/E
