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Difference between revisions of "E-R control efficiency"

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{{MitoPedia
{{MitoPedia
|abbr=''j<sub>ExR</sub>''
|abbr=''j<sub>ExR</sub>''
|description=[[Image:jExR.jpg|50 px|Excess ''E-R'' capacity factor]] The apparent '''excess ''E-R'' capacity factor''' (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in living cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of living cells is stimulated to [[ET-pathway]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''ExR''=''E-R''. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation.
|description=[[Image:jExR.jpg|50 px|Excess ''E-R'' capacity factor]] The apparent '''excess ''E-R'' capacity factor''' (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in living cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of living cells is stimulated to [[Electron transfer pathway]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''ExR''=''E-R''. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation.
|info=[[Flux control factor]]
|info=[[Flux control factor]]
}}
}}

Revision as of 08:43, 3 June 2020


high-resolution terminology - matching measurements at high-resolution


E-R control efficiency

Description

Excess E-R capacity factor The apparent excess E-R capacity factor (E-R coupling control factor), jExR = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in living cells by uncoupling. jExR = 0.0 for zero excess capacity when R=E; jExR = 1.0 for the maximum limit when R=0. The ROUTINE state of living cells is stimulated to Electron transfer pathway by uncoupler titration, which yields the excess E-R capacity, ExR=E-R. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), ExR or jExR is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent excess E-P capacity, ExP=E-P, is not a respiratory reserve in the sense of oxidative phosphorylation.

Abbreviation: jExR

Reference: Flux control factor


MitoPedia concepts: Respiratory control ratio 






Compare

Β» ROUTINE control ratio, R/E
Β» Excess E-P capacity factor, jExP = (E-P)/E = 1-P/E
Β» ET-coupling efficiency, jβ‰ˆE = 1-L/E