E-L net ET capacity

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E-L net ET capacity

Description

The free ET capacity, E-L, is the ET capacity corrected for LEAK respiration. E-L is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET capacity, E-L, and LEAK respiration, L_P, compensating for proton leaks, slip and cation cycling: E = E-L+L_P (see free OXPHOS capacity).

Abbreviation: E-L

Reference: Gnaiger 2020 MitoPathways

Communicated by Gnaiger E (2014-09-21) last upate 2020-11-07.

The Blue Book 2020

Coupling control states for E-L

» Respiratory state

• Reference state, rate Z_X: ET capacity; E = E´-Rox
• Background state, rate Y_X: LEAK respiration; L = L´-Rox
• Metabolic control variable, X=Z_X-Y_X: Scope of uncoupler stimulation, Free ET capacity E-L

Flux control efficiency

» Flux control efficiency, j_Z-Y

• Coupling control efficiency, 1-Y_X/Z_X: E-L coupling control efficiency, ET-coupling efficiency: j_E-L = (E-L)/E = 1-L/E

Compare

• mt-Preparations Free OXPHOS capacity, P-L
• Intact cells Free ROUTINE activity, R-L