Difference between revisions of "Dlaskova 2010 Biochim Biophys Acta"
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|title=Dlasková A, Clarke KJ, Porter RK (2010) The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue. Biochim Biophys Acta 1797:1470-6. | |title=Dlasková A, Clarke KJ, Porter RK (2010) The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue. Biochim Biophys Acta 1797:1470-6. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/20416274 PMID: 20416274]; [http://www.tara.tcd.ie/bitstream/2262/40404/1/The%20role%20of%20UCP%201%20in%20production%20of%20reactive%20oxygen%20species%20by%20mitochondria%20isolated%20from%20brown%20adipose%20tissue.pdf PDF] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/20416274 PMID: 20416274 Open Access]; [http://www.tara.tcd.ie/bitstream/2262/40404/1/The%20role%20of%20UCP%201%20in%20production%20of%20reactive%20oxygen%20species%20by%20mitochondria%20isolated%20from%20brown%20adipose%20tissue.pdf PDF] | ||
|authors=Dlaskova A, Clarke KJ, Porter RK | |authors=Dlaskova A, Clarke KJ, Porter RK | ||
|year=2010 | |year=2010 | ||
Latest revision as of 12:09, 26 May 2015
| Dlasková A, Clarke KJ, Porter RK (2010) The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue. Biochim Biophys Acta 1797:1470-6. |
» PMID: 20416274 Open Access; PDF
Dlaskova A, Clarke KJ, Porter RK (2010) Biochim Biophys Acta
Abstract: We provide evidence that ablation or inhibition of, uncoupling protein 1 increases the rate of reactive oxygen containing species production by mitochondria from brown adipose tissue, no matter what electron transport chain substrate is used (succinate, glycerol-3-phosphate or pyruvate/malate). Consistent with these data are our observations that (a) the mitochondrial membrane potential is maximal when uncoupling protein 1 is ablated or inhibited and (b) oxygen consumption rates in mitochondria from uncoupling protein 1 knock-out mice, are significantly lower than those from wild-type mice, but equivalent to those from wild-type mice in the presence of GDP. In summary, we show that uncoupling protein 1 can affect reactive oxygen containing species production by isolated mitochondria from brown adipose tissue. • Keywords: Mitochondria, Reactive oxygen species, Brown adipose tissue, Uncoupling protein 1
• O2k-Network Lab: IE Dublin Porter RK
Labels: MiParea: Respiration, Genetic knockout;overexpression
Stress:Oxidative stress;RONS Organism: Mouse Tissue;cell: Fat Preparation: Isolated mitochondria Enzyme: Uncoupling protein
Coupling state: OXPHOS
HRR: Oxygraph-2k
