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Difference between revisions of "Convergent electron flow"

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|description=[[Image:SUIT-catg_FNSGp.jpg|right|300px|Convergent electron flow]]
|description=[[Image:SUIT-catg_FNSGp.jpg|right|300px|Convergent electron flow]]
'''Convergent electron flow''' is built into the metabolic design of the [[Electron transfer pathway]]. The glycolytic pathways are characterized by important ''divergent branchpoints'': phosphoenolpyruvate (PEPCK) branchpoint to pyruvate or oxaloactetate; pyruvate branchpoint to (aerobic) acetyl-CoA or (anaerobic) lactate or alanine. The mitochondrial Electron transfer pathway, in contrast, is characterized by ''convergent junctions'': (1) the [[N-junction]] and [[F-junction]] in the [[mitochondrial matrix]] at ET-pathway level 4, with dehydrogenases (including the TCA cycle) and ß-oxidation generating NADH and FADH<sub>2</sub> as substrates for [[Complex I]] and [[electron-transferring flavoprotein complex]], respectively, and (2) the [[Q-junction]] with inner mt-membrane respiratory complexes at ET-pathway level 3, reducing the oxidized ubiquinone and partially reduced semiquinone to the fully reduced ubiquinol, feeding electrons into [[Complex III]].
'''Convergent electron flow''' is built into the metabolic design of the [[Electron transfer pathway]]. The glycolytic pathways are characterized by important ''divergent branchpoints'': phosphoenolpyruvate (PEPCK) branchpoint to pyruvate or oxaloactetate; pyruvate branchpoint to (aerobic) acetyl-CoA or (anaerobic) lactate or alanine. The mitochondrial Electron transfer pathway, in contrast, is characterized by ''convergent junctions'': (1) the [[N-junction]] and [[F-junction]] in the [[mitochondrial matrix]] at ET-pathway level 4, with dehydrogenases (including the TCA cycle) and ß-oxidation generating NADH and FADH<sub>2</sub> as substrates for [[Complex I]] and [[electron-transferring flavoprotein complex]], respectively, and (2) the [[Q-junction]] with inner mt-membrane respiratory complexes at ET-pathway level 3, reducing the oxidized ubiquinone and partially reduced semiquinone to the fully reduced ubiquinol, feeding electrons into [[Complex III]].
|info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger_2009_Int J Biochem Cell Biol]]
|info=[[Gnaiger 2020 BEC MitoPathways]], [[Gnaiger_2009_Int J Biochem Cell Biol]]
}}
}}
::: ''More details''
::::Β» [[Additive effect of convergent electron flow]]
::::Β» [[Respiratory_complexes#Respiratory_complexes_-_more_than_five |Respiratory complexes - more than five]]
{{MitoPedia methods
{{MitoPedia methods
|mitopedia method=Respirometry
|mitopedia method=Respirometry
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|mitopedia topic=Substrate and metabolite
|mitopedia topic=Substrate and metabolite
}}
}}
::: ''More details''
::::Β» [[Additive effect of convergent electron flow]]
::::Β» [[Respiratory_complexes#Respiratory_complexes_-_more_than_five |Respiratory complexes - more than five]]

Latest revision as of 18:47, 1 January 2021


high-resolution terminology - matching measurements at high-resolution


Convergent electron flow

Description

Convergent electron flow

Convergent electron flow is built into the metabolic design of the Electron transfer pathway. The glycolytic pathways are characterized by important divergent branchpoints: phosphoenolpyruvate (PEPCK) branchpoint to pyruvate or oxaloactetate; pyruvate branchpoint to (aerobic) acetyl-CoA or (anaerobic) lactate or alanine. The mitochondrial Electron transfer pathway, in contrast, is characterized by convergent junctions: (1) the N-junction and F-junction in the mitochondrial matrix at ET-pathway level 4, with dehydrogenases (including the TCA cycle) and ß-oxidation generating NADH and FADH2 as substrates for Complex I and electron-transferring flavoprotein complex, respectively, and (2) the Q-junction with inner mt-membrane respiratory complexes at ET-pathway level 3, reducing the oxidized ubiquinone and partially reduced semiquinone to the fully reduced ubiquinol, feeding electrons into Complex III.

Abbreviation: n.a.

Reference: Gnaiger 2020 BEC MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol

More details
Β» Additive effect of convergent electron flow
Β» Respiratory complexes - more than five


MitoPedia methods: Respirometry 


MitoPedia topics: Substrate and metabolite