Difference between revisions of "Cheng 2010 FEBS Lett"
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inner mitochondrial membranes of various tissues, mtK(ATP), mtBK, and mtKv1.3. While the latter | inner mitochondrial membranes of various tissues, mtK(ATP), mtBK, and mtKv1.3. While the latter | ||
two share similarities with their plasma membrane counterparts, mtK(ATP) exhibits considerable differences | two share similarities with their plasma membrane counterparts, mtK(ATP) exhibits considerable differences | ||
with the plasma membrane K<sub>ATP</sub>-channel. One important function seems to be suppression | with the plasma membrane K<sub>(ATP)</sub>-channel. One important function seems to be suppression | ||
of release of proapototic substances from mitochondria through the PTP. Open potassium | of release of proapototic substances from mitochondria through the PTP. Open potassium | ||
channels tend to keep the PTP closed thus acting as antiapoptotic. Nevertheless, in their mode of | channels tend to keep the PTP closed thus acting as antiapoptotic. Nevertheless, in their mode of | ||
Revision as of 18:29, 29 October 2010
| Cheng Y, Debska-Vielhaber G, Siemen D (2010) Interaction of mitochondrial potassium channels with the permeability transition pore. FEBS Letters 584: 2005–2012. |
Cheng Y, Debska-Vielhaber G, Siemen D (2010) FEBS Lett.
Abstract: Three types of potassium channels cooperate with the permeability transition pore (PTP) in the inner mitochondrial membranes of various tissues, mtK(ATP), mtBK, and mtKv1.3. While the latter two share similarities with their plasma membrane counterparts, mtK(ATP) exhibits considerable differences with the plasma membrane K(ATP)-channel. One important function seems to be suppression of release of proapototic substances from mitochondria through the PTP. Open potassium channels tend to keep the PTP closed thus acting as antiapoptotic. Nevertheless, in their mode of action there are considerable differences among them. This review introduces three K+-channels and the PTP, and discusses known facts about their interaction. • Keywords: Mitochondria Ion channel, Permeability transition pore, Apoptosis, Mitochondrial potassium channel
Labels:
Stress:Cancer; Apoptosis; Cytochrome c"Cancer; Apoptosis; Cytochrome c" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property.
HRR: Oxygraph-2k
