Chakrabarti L 2022 Abstract Bioblast

Ebanks B, Katyal G, Papetti C, Lucassen M, Marks FC, Chakrabarti Lisa (2022) "Going south!” An Antarctic expedition to understand more about mitochondrial haemoglobin and ageing.. Bioblast 2022: BEC Inaugural Conference.

Link: Bioblast 2022: BEC Inaugural Conference

Ebanks Brad, Katyal Gunjan, Papetti Chiara, Lucassen Magnus, Marks Felix Christopher, Chakrabarti Lisa (2022)

Event: Bioblast 2022

Mitochondrial dysfunction is intimately associated with ageing and diseases that occur more frequently with advancing age. We showed the presence of haemoglobin in mitochondria [1-3]. We found variations in the quantity of mitochondrial haemoglobin in neurodegeneration and also in animals experimentally exposed to hypoxia. Non-erythrocyte haemoglobin was unexpected, comparable to non-muscle myoglobin [4]. Its function is still not entirely clear. A standard approach to discover the function of a protein in a tissue is to remove it, knock it ‘out’ or ‘down’. For essential proteins like haemoglobin in the vertebrate context, this is unlikely to be a successful route of investigation. However, there is an unusual group of fish known as the ‘icefish’ that do not express haemoglobin nor myoglobin in skeletal muscle - these fish are only found in the cold waters of Antarctica [5]. In collaboration with the German polar research institute(AWI) and other fish biologists, we started our investigations into how icefish maintain mitochondrial function without haemoglobin. This line of research led me to an expedition in Antarctica earlier this year, where we performed icefish respirometry on board RV Polarstern.

1. Shephard F, Greville-Heygate O, Marsh O, Anderson S, Chakrabarti L (2014) A mitochondrial location for haemoglobins--dynamic distribution in ageing and Parkinson's disease. https://doi.org/10.1016/j.mito.2013.12.001
2. Freed J, Chakrabarti L (2016) Defining a role for hemoglobin in Parkinson's disease. https://doi.org/10.1038/npjparkd.2016.21
3. Shephard F, Greville-Heygate O, Liddell S, Emes R, Chakrabarti L (2016) Analysis of mitochondrial haemoglobin in Parkinson's disease brain. https://doi.org/10.1016/j.mito.2016.05.001
4. Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? https://doi.org/10.1074/jbc.M111.227553
5. Sidell BD, O'Brien KM (2006) When bad things happen to good fish: the loss of hemoglobin and myoglobin expression in Antarctic icefishes. https://doi.org/10.1242/jeb.02091

• O2k-Network Lab: UK Nottingham Chakrabarti L

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