Difference between revisions of "Chakrabarti L 2022 Abstract Bioblast"

Latest revision as of 08:26, 28 July 2022

1.2. «10+5» Ebanks B, Katyal G, Papetti C, Lucassen M, Marks FC, Chakrabarti Lisa (2022) "Going south!” An Antarctic expedition to understand more about mitochondrial haemoglobin and ageing. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001

Link: Bioblast 2022: BEC Inaugural Conference

Ebanks Brad, Katyal Gunjan, Papetti Chiara, Lucassen Magnus, Marks Felix Christopher, Chakrabarti Lisa (2022)

Event: Bioblast 2022

Mitochondrial dysfunction is intimately associated with ageing and diseases that occur more frequently with advancing age. Work we published some years ago showed the presence of haemoglobin in mitochondria. We found variations in the quantity of mitochondrial haemoglobin in neurodegeneration and also in animals experimentally exposed to hypoxia. Non-erythrocyte haemoglobin was unexpected and its function is still not entirely clear. A standard approach to discover the function of a protein in a tissue is to remove it, knock it ‘out’ or ‘down’. For essential proteins like haemoglobin in the vertebrate context, this is unlikely to be a successful route of investigation. However, there is an unusual group of fish known as the ‘icefish’ that do not express haemoglobin - these fish are only found in the cold waters of Antarctica. In collaboration with the German polar research institute (AWI) and other fish biologists, we started our investigations into how icefish maintain mitochondrial function without haemoglobin. This line of research led me to an expedition in Antarctica earlier this year, where we performed icefish respirometry on board RV Polarstern.

• Keywords: Haemoglobin, Ageing, Neurodegeneration, Icefish, Antarctica

• O2k-Network Lab: UK Nottingham Chakrabarti L

Affiliations

Ebanks B¹, Katyal G¹, Papetti C², Lucassen M³, Marks FC³, Chakrabarti L¹

School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, UK - [email protected]
Biology department, University of Padova, Padova, Italy
Alfred Wegener Institute, Bremerhaven, Germany

List of abbreviations, terms and definitions - MitoPedia

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Event: A1

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+[[File:Bioblast2022 banner.jpg|link=Bioblast_2022]]
 {{Abstract
-|title=[[File:Chakrabarti L.jpg|left|100px|Chakrabarti Lisa]]   Ebanks B, Katyal G, Papetti C, Lucassen M, Marks FC, <u>Chakrabarti Lisa</u> (2022) "Going south!” An Antarctic expedition to understand more about mitochondrial haemoglobin and ageing.. Bioblast 2022: BEC Inaugural Conference.<br>
+|title=1.2. '''«10+5»''' [[File:Chakrabarti L.jpg|left|100px|Chakrabarti Lisa]] Ebanks B, Katyal G, Papetti C, Lucassen M, Marks FC, <u>Chakrabarti Lisa</u> (2022) "Going south!” An Antarctic expedition to understand more about mitochondrial haemoglobin and ageing. '''Bioblast 2022: BEC Inaugural Conference.''' In: https://doi.org/10.26124/bec:2022-0001 [[File:WatchThePresentationYoutube_icon.jpg|200px|link=https://www.youtube.com/watch?v=F5s4sZLAubc&t=3537s|»''Watch the presentation''«]]
 |info=[https://wiki.oroboros.at/index.php/Bioblast_2022#Submitted_abstracts Bioblast 2022: BEC Inaugural Conference]
 |authors=Ebanks Brad, Katyal Gunjan, Papetti Chiara, Lucassen Magnus, Marks Felix Christopher, Chakrabarti Lisa
 |year=2022
 |event=[[Bioblast 2022]]
-|abstract=Mitochondrial dysfunction is intimately associated with ageing and diseases that occur more frequently with advancing age. We showed the presence of haemoglobin in mitochondria [1-3]. We found variations in the quantity of mitochondrial haemoglobin in neurodegeneration and also in animals experimentally exposed to hypoxia. Non-erythrocyte haemoglobin was unexpected, comparable to non-muscle myoglobin [4]. Its function is still not entirely clear. A standard approach to discover the function of a protein in a tissue is to remove it, knock it ‘out’ or ‘down’. For essential proteins like haemoglobin in the vertebrate context, this is unlikely to be a successful route of investigation. However, there is an unusual group of fish known as the ‘icefish’ that do not express haemoglobin nor myoglobin in skeletal muscle - these fish are only found in the cold waters of Antarctica [5]. In collaboration with the German polar research institute(AWI) and other fish biologists, we started our investigations into how icefish maintain mitochondrial function without haemoglobin. This line of research led me to an expedition in Antarctica earlier this year, where we performed icefish respirometry on board RV Polarstern.<br>
+|abstract=Mitochondrial dysfunction is intimately associated with ageing and diseases that occur more frequently with advancing age. Work we published some years ago showed the presence of haemoglobin in mitochondria. We found variations in the quantity of mitochondrial haemoglobin in neurodegeneration and also in animals experimentally exposed to hypoxia. Non-erythrocyte haemoglobin was unexpected and its function is still not entirely clear. A standard approach to discover the function of a protein in a tissue is to remove it, knock it ‘out’ or ‘down’. For essential proteins like haemoglobin in the vertebrate context, this is unlikely to be a successful route of investigation. However, there is an unusual group of fish known as the ‘icefish’ that do not express haemoglobin - these fish are only found in the cold waters of Antarctica. In collaboration with the German polar research institute (AWI) and other fish biologists, we started our investigations into how icefish maintain mitochondrial function without haemoglobin. This line of research led me to an expedition in Antarctica earlier this year, where we performed icefish respirometry on board RV Polarstern.
-<small>
-# Shephard F, Greville-Heygate O, Marsh O, Anderson S, Chakrabarti L (2014) A mitochondrial location for haemoglobins--dynamic distribution in ageing and Parkinson's disease. https://doi.org/10.1016/j.mito.2013.12.001
-# Freed J, Chakrabarti L (2016) Defining a role for hemoglobin in Parkinson's disease. https://doi.org/10.1038/npjparkd.2016.21
-# Shephard F, Greville-Heygate O, Liddell S, Emes R, Chakrabarti L (2016) Analysis of mitochondrial haemoglobin in Parkinson's disease brain. https://doi.org/10.1016/j.mito.2016.05.001
-# Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? https://doi.org/10.1074/jbc.M111.227553
-# Sidell BD, O'Brien KM (2006) When bad things happen to good fish: the loss of hemoglobin and myoglobin expression in Antarctic icefishes. https://doi.org/10.1242/jeb.02091
-</small>
 |keywords=Haemoglobin, Ageing, Neurodegeneration, Icefish, Antarctica
 |mipnetlab=UK Nottingham Chakrabarti L
 }}
-{{Labeling
+== Affiliations ==
-|articletype=Abstract
+:::: Ebanks B<sup>1</sup>, Katyal G<sup>1</sup>, Papetti C<sup>2</sup>, Lucassen M<sup>3</sup>, Marks FC<sup>3</sup>, Chakrabarti L<sup>1</sup>
-}}
-[[File:Bioblast2022 banner.jpg|link=Bioblast_2022]]
-== Affiliations and support ==
+::::# School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, UK  - [email protected]
+::::# Biology department, University of Padova, Padova, Italy
+::::# Alfred Wegener Institute, Bremerhaven, Germany
 == List of abbreviations, terms and definitions - MitoPedia ==
 {{Template:List of abbreviations, terms and definitions - MitoPedia}}
+{{Labeling
+|event=A1
+|articletype=Abstract
+}}