Difference between revisions of "BEC 2020.1 doi10.26124bec2020-0001.v1"

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|couplingstates=LEAK, OXPHOS, ET
 
|couplingstates=LEAK, OXPHOS, ET
 
|pathways=F, N, S, Gp, DQ, CIV, NS, Other combinations, ROX
 
|pathways=F, N, S, Gp, DQ, CIV, NS, Other combinations, ROX
|additional=MitoFitPublication, MitoEAGLEPublication, AMP, ADP, ATP, Adenylates, Amount, ATP yield, Respiration, Count, Mass, Concentration, Concentration, Cell viability, Charge number, Complex I, Complex II, Complex III, Complex IV, Concentration, Format, Count, Coupling control ratio, Coupling control state, Cell viability, Format, Electron transfer-pathway, Electron transfer-pathway, Entity, ET-capacity, Flow, Flux, Flux control ratio, Phosphate, Phosphate carrier, IUPAC, International System of Units, Isolated mitochondria, Living cells, LEAK-respiration, Format, MITOCARTA, MitoPedia, Mitochondria, Mitochondrial marker, Density, Mitochondrial inner membrane, Mitochondrial outer membrane, Mitochondrial preparations, Mitochondrial recovery, Mitochondrial yield, Molar mass, Protonmotive force, Normalization of rate, Cell viability, Organism, Oxidative phosphorylation, Oxygen concentration, Oxygen solubility, Oxygen flux, Pathway control state, Permeability transition, Permeabilized cells, Permeabilized muscle fibers, Permeabilized tissue, Ergodynamic efficiency, LEAK-respiration, OXPHOS-capacity, Residual oxygen consumption, Respiration, MitoPedia: Respiratory states, Supercomplex, Sample, Substrate-uncoupler-inhibitor-titration, Tissue homogenate, Uncoupler titrations, Volume
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|additional=MitoFitPublication, MitoEAGLEPublication, Alternative oxidase, AMP, ADP, ATP, Adenylates, Amount, ATP yield, Respiration, Count, Mass, Concentration, Concentration, Cell viability, Charge number, Complex I, Complex II, Complex III, Complex IV, Concentration, Format, Count, Coupling control ratio, Coupling control state, Cell viability, Format, Electron transfer-pathway, Electron transfer-pathway, Entity, ET-capacity, Flow, Flux, Flux control ratio, Phosphate, Phosphate carrier, IUPAC, International System of Units, Isolated mitochondria, Living cells, LEAK-respiration, Format, MITOCARTA, MitoPedia, Mitochondria, Mitochondrial marker, Density, Mitochondrial inner membrane, Mitochondrial outer membrane, Mitochondrial preparations, Mitochondrial recovery, Mitochondrial yield, Molar mass, Protonmotive force, Normalization of rate, Cell viability, Organism, Oxidative phosphorylation, Oxygen concentration, Oxygen solubility, Oxygen flux, Pathway control state, Permeability transition, Permeabilized cells, Permeabilized muscle fibers, Permeabilized tissue, Ergodynamic efficiency, LEAK-respiration, OXPHOS-capacity, Residual oxygen consumption, Respiration, MitoPedia: Respiratory states, Supercomplex, Sample, Substrate-uncoupler-inhibitor-titration, Tissue homogenate, Uncoupler titrations, Volume
 
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Revision as of 15:33, 26 May 2020


Bioenergetics Communications         BEC2020.1 MitoPhysiology         Formats         Authors         Editors         Reviewers         MitoPedia: BEC         MitoPedia: Gentle Science         MitoFit Preprint Archives         DOI Data Center
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BEC 2020.1 doi10.26124bec2020-0001.v1

Bioenergetics Communications
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CA15203 MitoEAGLE
Mitochondrial physiology
Publications in the MiPMap
Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1.

» BEC 2020.1 pdfPublished online: 2020-May-20

Author affiliations in hyperlinks:, Gnaiger Erich, Aasander Frostner Eleonor, Abdul Karim Norwahidah, Abdel-Rahman Engy Ali, Abumrad Nada A, Acuna-Castroviejo Dario, Adiele Reginald C, Ahn Bumsoo, Alencar Mayke Bezerra, Ali Sameh S, Almeida Angeles, Alton Lesley, Alves Marco G, Amati Francesca, Amoedo Nivea Dias, Amorim Ricardo, Anderson Ethan J, Andreadou Ioanna, Antunes Diana, Arago Marc, Aral Cenk, Arandarcikaite Odeta, Arias-Reyes Christian, Armand Anne-Sophie, Arnould Thierry, Avram Vlad F, Axelrod Christopher L, Bailey Damian M, Bairam Aida, Bajpeyi Sudip, Bajzikova Martina, Bakker Barbara M, Banni Aml, Bardal Tora, Barlow J, Bastos Sant'Anna Silva Ana Carolina, Batterson Philip M, Battino Maurizio, Bazil Jason N, Beard Daniel A, Bednarczyk Piotr, Beleza Jorge, Bello Fiona, Ben-Shachar Dorit, Bento Guida Jose Freitas, Bergdahl Andreas, Berge Rolf K, Bergmeister Lisa, Bernardi Paolo, Berridge Michael V, Bettinazzi Stefano, Bishop David J, Blier Pierre U, Blindheim Dan Filip, Boardman Neoma T, Boetker Hans Erik, Borchard Sabine, Boros Mihaly, Boersheim Elisabet, Borras Consuelo, Borutaite Vilma, Botella Javier, Bouillaud Frederic, Bouitbir Jamal, Boushel Robert C, Bovard Josh, Bravo-Sagua Roberto, Breton Sophie, Brown David A, Brown Guy C, Brown Robert Andrew, Brozinick Joseph T, Buettner Garry R, Burtscher Johannes, Bustos Matilde, Calabria Elisa, Calbet Jose AL, Calzia Enrico, Cannon Daniel T, Cano Sanchez Maria Consolacion, Canto Alvarez Carles, Cardinale Daniele A, Cardoso Luiza HD, Carvalho Eugenia, Casado Pinna Marta, Cassar Samantha, Castelo Rueda Maria Paulina, Castilho Roger F, Cavalcanti-de-Albuquerque Joao Paulo, Cecatto Cristiane, Celen Murat C, Cervinkova Zuzana, Chabi Beatrice, Chakrabarti Lisa, Chakrabarti Sasanka, Chaurasia Bhagirath, Chen Quan, Chicco Adam J, Chinopoulos Christos, Chowdhury Subir Kumar, Cizmarova Beata, Clementi Emilio, Coen Paul M, Cohen Bruce H, Coker Robert H, Collin-Chenot Anne, Coughlan Melinda T, Coxito Pedro, Crisostomo Luis, Crispim Marcell, Crossland Hannah, Dahdah Norma Ramon, Dalgaard Louise T, Dambrova Maija, Danhelovska Tereza, Darveau Charles-A, Darwin Paula M, Das Anibh Martin, Dash Ranjan K, Davidova Eliska, Davis Michael S, Dayanidhi Sudarshan, De Bem Andreza Fabro, De Goede Paul, De Palma Clara, De Pinto Vito, Dela Flemming, Dembinska-Kiec Aldona, Detraux Damian, Devaux Yvan, Di Marcello Marco, Di Paola Floriana Jessica, Dias Candida, Dias Tania R, Diederich Marc, Distefano Giovanna, Djafarzadeh Siamak, Doermann Niklas, Doerrier Carolina, Dong Lan-Feng, Donnelly Chris, Drahota Zdenek, Duarte Filipe Valente, Dubouchaud Herve, Duchen Michael R, Dumas Jean-Francois, Durham William J, Dymkowska Dorota, Dyrstad Sissel E, Dyson Alex, Dzialowski Edward M, Eaton Simon, Ehinger Johannes K, Elmer Eskil, Endlicher Rene, Engin Ayse Basak, Escames Germaine, Evinova Andrea, Ezrova Zuzana, Falk Marni J, Fell David A, Ferdinandy Peter, Ferko Miroslav, Fernandez-Ortiz Marisol, Fernandez-Vizarra Erika, Ferreira Julio Cesar B, Ferreira Rita Maria P, Ferri Alessandra, Fessel Joshua Patrick, Festuccia William T, Filipovska Aleksandra, Fisar Zdenek, Fischer Christine, Fischer Michael J, Fisher Gordon, Fisher Joshua J, Fontanesi Flavia, Forbes-Hernandez Tamara Y, Ford Ellen, Fornaro Mara, Fuertes Agudo Marina, Fulton Montana, Galina Antonio, Galkin Alexander, Gallee Leon, Galli Gina L J, Gama Perez Pau, Gan Zhenji, Ganetzky Rebecca, Gao Yun, Garcia Geovana S, Garcia-Rivas Gerardo, Garcia-Roves Pablo Miguel, Garcia-Souza Luiz F, Garlid Keith D, Garrabou Gloria, Garten Antje, Gastaldelli Amalia, Gayen Jiaur, Genders Amanda J, Genova Maria Luisa, Giampieri Francesca, Giovarelli Matteo, Glatz Jan FC, Goikoetxea Usandizaga Naroa, Goncalo Teixeira da Silva Rui, Goncalves Debora Farina, Gonzalez-Armenta Jenny L, Gonzalez-Franquesa Alba, Gonzalez-Freire Marta, Gonzalo Hugo, Goodpaster Bret H, Gorr Thomas A, Gourlay Campbell W, Grams Bente, Granata Cesare, Grefte Sander, Grilo Luis, Guarch Meritxell Espino, Gueguen Naig, Gumeni Sentiljana, Haas Clarissa, Haavik Jan, Hachmo Yafit, Haendeler Judith, Haider Markus, Hajrulahovic Anesa, Hamann Andrea, Han Jin, Han Woo Hyun, Hancock Chad R, Hand Steven C, Handl Jiri, Hansikova Hana, Hardee Justin P, Hargreaves Iain P, Harper Mary-Ellen, Harrison David K, Hassan Hazirah, Hatokova Zuzana, Hausenloy Derek J, Heales Simon JR, Hecker Matthias, Heiestad Christina, Hellgren Kim T, Henrique Alexandrino, Hepple Russell T, Hernansanz-Agustin Pablo, Hewakapuge Sudinna, Hickey Anthony J, Ho Dieu Hien, Hoehn Kyle L, Hoel Fredrik, Holland Olivia J, Holloway Graham P, Holzner Lorenz, Hoppel Charles L, Hoppel Florian, Hoppeler Hans, Houstek Josef, Huete-Ortega Maria, Hyrossova Petra, Iglesias-Gonzalez Javier, Indiveri Cesare, Irving Brian A, Isola Raffaella, Iyer Shilpa, Jackson Christopher Benjamin, Jadiya Pooja, Jana Prado Fabian, Jandeleit-Dahm Karin, Jang David H, Jang Young Charles, Janowska Joanna, Jansen Kirsten M, Jansen-Duerr Pidder, Jansone Baiba, Jarmuszkiewicz Wieslawa, Jaskiewicz Anna, Jaspers Richard T, Jedlicka Jan, Jerome Estaquier, Jespersen Nichlas Riise, Jha Rajan Kumar, Jones John G, Joseph Vincent, Juhasz Laszlo, Jurczak Michael J, Jurk Diana, Jusic Amela, Kaambre Tuuli, Kaczor Jan Jacek, Kainulainen Heikki, Kampa Rafal Pawel, Kandel Sunil Mani, Kane Daniel A, Kapferer Werner, Kapnick Senta, Kappler Lisa, Karabatsiakis Alexander, Karavaeva Iuliia, Karkucinska-Wieckowska Agnieszka, Kaur Sarbjot, Keijer Jaap, Keller Markus A, Keppner Gloria, Khamoui Andy V, Kidere Dita, Kilbaugh Todd, Kim Hyoung Kyu, Kim Julian KS, Kimoloi Sammy, Klepinin Aleksandr, Klepinina Lyudmila, Klingenspor Martin, Klocker Helmut, Kolassa Iris, Komlodi Timea, Koopman Werner JH, Kopitar-Jerala Natasa, Kowaltowski Alicia J, Kozlov Andrey V, Krajcova Adela, Krako Jakovljevic Nina, Kristal Bruce S, Krycer James R, Kuang Jujiao, Kucera Otto, Kuka Janis, Kwak Hyo Bum, Kwast Kurt E, Kwon Oh Sung, Laasmaa Martin, Labieniec-Watala Magdalena, Lagarrigue Sylviane, Lai Nicola, Lalic Nebojsa M, Land John M, Lane Nick, Laner Verena, Lanza Ian R, Laouafa Sofien, Laranjinha Joao, Larsen Steen, Larsen Terje S, Lavery Gareth G, Lazou Antigone, Ledo Ana Margarida, Lee Hong Kyu, Leeuwenburgh Christiaan, Lehti Maarit, Lemieux Helene, Lenaz Giorgio, Lerfall Joergen, Li Pingan Andy, Li Puma Lance, Liang Liping, Liepins Edgars, Lin Chien-Te, Liu Jiankang, Lopez Garcia Luis Carlos, Lucchinetti Eliana, Ma Tao, Macedo Maria Paula, Machado Ivo F, Maciej Sarah, MacMillan-Crow Lee Ann, Magalhaes Jose, Magri Andrea, Majtnerova Pavlina, Makarova Elina, Makrecka-Kuka Marina, Malik Afshan N, Marcouiller Francois, Marechal Amandine, Markova Michaela, Markovic Ivanka, Martin Daniel S, Martins Ana Dias, Martins Joao D, Maseko Tumisang Edward, Maull Felicia, Mazat Jean-Pierre, McKenna Helen T, McKenzie Matthew, McMillan Duncan GG, McStay Gavin P, Mendham Amy, Menze Michael A, Mercer John R, Merz Tamara, Messina Angela, Meszaros Andras, Methner Axel, Michalak Slawomir, Mila Guasch Maria, Minuzzi Luciele M, Misirkic Marjanovic Maja, Moellering Douglas R, Moisoi Nicoleta, Molina Anthony JA, Montaigne David, Moore Anthony L, Moore Christy, Moreau Kerrie, Moreira Bruno P, Moreno-Sanchez Rafael, Mracek Tomas, Muccini Anna Maria, Munro Daniel, Muntane Jordi, Muntean Danina M, Murray Andrew James, Musiol Eva, Nabben Miranda, Nair K Sreekumaran, Nehlin Jan O, Nemec Michal, Nesci Salvatore, Neufer P Darrell, Neuzil Jiri, Neviere Remi, Newsom Sean A, Norman Jennifer, Nozickova Katerina, Nunes Sara, Nuoffer Jean-Marc, O'Brien Kristin, O'Brien Katie A, O'Gorman Donal, Olgar Yusuf, Oliveira Ben, Oliveira Jorge, Oliveira Marcus F, Oliveira Marcos Tulio, Oliveira Pedro Fontes, Oliveira Paulo J, Olsen Rolf Erik, Orynbayeva Zulfiya, Osiewacz Heinz D, Paez Hector, Pak Youngmi Kim, Pallotta Maria Luigia, Palmeira Carlos, Parajuli Nirmala, Passos Joao F, Passrugger Manuela, Patel Hemal H, Pavlova Nadia, Pavlovic Kasja, Pecina Petr, Pedersen Tina M, Perales Jose Carles, Pereira da Silva Grilo da Silva Filomena, Pereira Rita, Pereira Susana P, Perez Valencia Juan Alberto, Perks Kara L, Pesta Dominik, Petit Patrice X, Pettersen Nitschke Ina Katrine, Pichaud Nicolas, Pichler Irene, Piel Sarah, Pietka Terri A, Pinho Sonia A, Pino Maria F, Pirkmajer Sergej, Place Nicolas, Plangger Mario, Porter Craig, Porter Richard K, Preguica Ines, Prigione Alessandro, Procaccio Vincent, Prochownik Edward V, Prola Alexandre, Pulinilkunnil Thomas, Puskarich Michael A, Puurand Marju, Radenkovic Filip, Ramzan Rabia, Rattan Suresh IS, Reano Simone, Reboredo-Rodriguez Patricia, Rees Bernard B, Renner-Sattler Kathrin, Rial Eduardo, Robinson Matthew M, Roden Michael, Rodrigues Ana Sofia, Rodriguez Enrique, Rodriguez-Enriquez Sara, Roesland Gro Vatne, Rohlena Jakub, Rolo Anabela Pinto, Ropelle Eduardo R, Roshanravan Baback, Rossignol Rodrigue, Rossiter Harry B, Rousar Tomas, Rubelj Ivica, Rybacka-Mossakowska Joanna, Saada Reisch Ann, Safaei Zahra, Salin Karine, Salvadego Desy, Sandi Carmen, Saner Nicholas, Santos Diana, Sanz Alberto, Sardao Vilma, Sarlak Saharnaz, Sazanov Leonid A, Scaife Paula, Scatena Roberto, Schartner Melanie, Scheibye-Knudsen Morten, Schilling Jan M, Schlattner Uwe, Schmitt Sabine, Schneider Gasser Edith Mariane, Schoenfeld Peter, Schots Pauke C, Schulz Rainer, Schwarzer Christoph, Scott Graham R, Selman Colin, Sendon Pamella Marie, Shabalina Irina G, Sharma Pushpa, Sharma Vipin, Shevchuk Igor, Shirazi Reza, Shiroma Jonathan G, Siewiera Karolina, Silber Ariel M, Silva Ana Maria, Sims Carrie A, Singer Dominique, Singh Brijesh Kumar, Skolik Robert A, Smenes Benedikte Therese, Smith James, Soares Felix Alexandre Antunes, Sobotka Ondrej, Sokolova Inna, Solesio Maria E, Soliz Jorge, Sommer Natascha, Sonkar Vijay K, Sova Marina, Sowton Alice P, Sparagna Genevieve C, Sparks Lauren M, Spinazzi Marco, Stankova Pavla, Starr Jonathan, Stary Creed, Stefan Eduard, Stelfa Gundega, Stepto Nigel K, Stevanovic Jelena, Stiban Johnny, Stier Antoine, Stocker Roland, Storder Julie, Sumbalova Zuzana, Suomalainen Anu, Suravajhala Prashanth, Svalbe Baiba, Swerdlow Russell H, Swiniuch Daria, Szabo Ildiko, Szewczyk Adam, Szibor Marten, Tanaka Masashi, Tandler Bernard, Tarnopolsky Mark A, Tausan Daniel, Tavernarakis Nektarios, Teodoro Joao Soeiro, Tepp Kersti, Thakkar Himani, Thapa Maheshwor, Thyfault John P, Tomar Dhanendra, Ton Riccardo, Torp May-Kristin, Torres-Quesada Omar, Towheed Atif, Treberg Jason R, Tretter Laszlo, Trewin Adam J, Trifunovic Aleksandra, Trivigno Catherine, Tronstad Karl Johan, Trougakos Ioannis P, Truu Laura, Tuncay Erkan, Turan Belma, Tyrrell Daniel J, Urban Tomas, Urner Sofia, Valentine Joseph Marco, Van Bergen Nicole J, Van der Ende Miranda, Varricchio Frederick, Vaupel Peter, Vella Joanna, Vendelin Marko, Vercesi Anibal E, Verdaguer Ignasi Bofill, Vernerova Andrea, Victor Victor Manuel, Vieira Ligo Teixeira Camila, Vidimce Josif, Viel Christian, Vieyra Adalberto, Vilks Karlis, Villena Josep A, Vincent Vinnyfred, Vinogradov Andrey D, Viscomi Carlo, Vitorino Rui Miguel Pinheiro, Vlachaki Walker Julia, Vogt Sebastian, Volani Chiara, Volska Kristine, Votion Dominique-Marie, Vujacic-Mirski Ksenija, Wagner Brett A, Ward Marie Louise, Warnsmann Verena, Wasserman David H, Watala Cezary, Wei Yau-Huei, Weinberger Klaus M, Weissig Volkmar, White Sarah Haverty, Whitfield Jamie, Wickert Anika, Wieckowski Mariusz R, Wiesner Rudolf J, Williams Caroline M, Winwood-Smith Hugh, Wohlgemuth Stephanie E, Wohlwend Martin, Wolff Jonci Nikolai, Wrutniak-Cabello Chantal, Wuest Rob CI, Yokota Takashi, Zablocki Krzysztof, Zanon Alessandra, Zanou Nadege, Zaugg Kathrin, Zaugg Michael, Zdrazilova Lucie, Zhang Yong, Zhang Yizhu, Zikova Alena, Zischka Hans, Zorzano Antonio, Zujovic Tijana, Zurmanova Jitka, Zvejniece Liga (2020) Bioenerg Commun

Abstract: Version 1 (v1) 2020-05-20 doi:10.26124/bec:2020-0001.v1

Versions (v1) 2020-05-20 - »Link to all versions«

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.


Bioblast editor: Gnaiger E

Overview. Internal and external respiration. (mt) Mitochondrial catabolic respiration JkO2 is the O2 consumption in the oxidation of fuel substrates (electron donors) and reduction of O2 catalysed by the electron transfer system ETS, which drives the protonmotive force pmF. JkO2 excludes mitochondrial residual oxygen consumption, mt-Rox (1). (ce) Cell respiration JrO2 is internal cellular O2 consumption, taking into account all chemical reactions r that consume O2 in the cells. Catabolic cell respiration is the O2 consumption associated with catabolic pathways in the cell, including mitochondrial (mt) catabolism, and: mt-Rox (1); non-mt O2 consumption by catabolic reactions, particularly peroxisomal oxidases and microsomal cytochrome P450 systems (2); non-mt Rox by reactions unrelated to catabolism (3). (ext) External respiration balances internal respiration at steady-state, including extracellular Rox (4) and aerobic respiration by the microbiome (5). O2 is transported from the environment across the respiratory cascade, i.e., circulation between tissues and diffusion across cell membranes, to the intracellular compartment. The respiratory quotient RQ is the molar CO2/O2 exchange ratio; when combined with the respiratory nitrogen quotient N/O2 (mol N given off per mol O2 consumed), the RQ reflects the proportion of carbohydrate, lipid and protein utilized in cell respiration during aerobically balanced steady-states. Bicarbonate and CO2 are transported in reverse to the extracellular milieu and the organismic environment. Hemoglobin provides the molecular paradigm for the combination of O2 and CO2 exchange, as do lungs, gills, the skin and other surfaces on the morphological level. Respiratory states are defined in Table 1. Rates are illustrated in Figure 5. Consult Tables 4 and 8 for terms and symbols.

Keywords—MitoPedia

Cell countCoupling controlElectron transfer-pathwayFlowFluxFlux control ratioIUPACLEAK-respirationMitochondrial markerMitochondrial preparationsRespiratory statesNormalization of rateOxidative phosphorylationOxygenPhosphorylation efficiencyProtonmotive forceResidual oxygen consumptionSI - The International System of UnitsUncoupling



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MitoPedia Keywords—MitoPedia - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

Keywords—MitoPedia, including Table 8. Terms, symbols, and units. SI base units are used, except for the liter [L = dm3]. SI refers to ref. [11].

Term Link to MitoPedia term Symbol Unit Links and comments
adenosine diphosphate ADP ADP - Tab. 1; Fig. 1, 2, 5
adenosine monophosphate AMP AMP - 2 ADP ↔ ATP+AMP
adenosine triphosphate ATP ATP - Fig. 2, 5
adenylates Adenine nucleotides AMP, ADP, ATP - Section 2.5.1
alternative quinol oxidase Alternative oxidase AOX - Fig. 1B
amount of substance B Amount nB or n(B) [mol] SI; amount nB of B versus count NB of B
ATP yield per O2 ATP yield YP»/O2 1 P»/O2 ratio measured in any respiratory state
catabolic rate of respiration Cell respiration JkO2; IkO2 varies Fig. 1, 3; flux J versus flow I
catabolic reaction Cell respiration k - Fig. 1, 3
cell count Count Nce [x] Tab. 4; Fig. 5; see number of cells; countable object s=ce
cell-count concentration Concentration Cce [x∙L­-1] Tab. 4; Cce = NceV-1; count concentration C versus amount concentration c; subscript ce indicates the entity type: concentration of ce. But it does not signal 'per entity', which would be written as 'per cell' Xce.
cell mass Body mass mce [kg] Tab. 5; Fig. 5; mass of cells m versus mass per cell (per single entity cell) MXce
cell mass, mass per cell Body mass MXce [kg∙x­-1] Tab. 5; Fig. 5; mass per single cell MXce; upper case M and subscript X signal 'per count', subscript ce signals the entity s=ce; in a context restricted to cells or molecules or a particular organism such as humans, the abbreviated symbol M [kg∙x­-1] provides a sufficiently informative signal, particularly in combination with the explicit unit.
cell-mass concentration in chamber Concentration Cmce [kg∙L­-1] see Cms: Tab. 4; Cmce = mceV-1; upper case C alone would signal 'count concentration' (CN is more explicit), whereas the signal for 'mass concentration' is in the combination Cm.
cell viability index Cell viability VI - VI = NvceNce­-1 = 1 - NdceNce­-1
charge number per entity XB Charge number zB 1 zB = QB·e-1 (IUPAC); Tab. 6; zO2 = = QO2·e-1 = 4; IUPAC uses the term 'charge number of an ion' which should be changed to 'charge number per ion', or more clearly to 'charge number per ion number'. The symbol z carries the message 'number of elementary charges per number', and the subscript carries the message on the type of entity X.
Complexes I to IV Complex I CI to CIV - respiratory ET Complexes are redox proton pumps; Fig. 1B; F1FO-ATPase is not a redox proton pump of the ETS, hence the term CV is not recommended
concentration of B, amount Concentration cB = NB-1 [mol∙L­-1] SI: amount of substance concentration [[[Cohen 2008 IUPAC Green Book |24]]]; the molar and count formats are distinguished as nB and NB, respectively.
concentration of O2, amount Concentration cO2 = nO2-1 [mol∙L­-1] Box 2; [O2]
concentration of s, count Concentration Cs = Ns-1 [x∙L-1] Tab. 4 (number concentration [[[Cohen 2008 IUPAC Green Book |24]]]); the signal for count concentration is given by the upper case C in contrast to c for amount concentration. In both cases, the subscript X indicates the entity type, not to be confused with a number of entities.
count format Format N [x] Tab. 4, 5; Fig. 5
count of Xs Count Ns [x] SI; see number of entities Xs
coupling control Coupling-control ratio CCR - Section 2.4.1
coupling control state Coupling control state CCS - Section 2.4.1
dead cells Cell viability dce - Tab. 5
electrical format Format e [C] Tab. 6
electron transfer pathway Electron transfer pathway ET pathway - Overview; Fig. 1
electron transfer, state Electron transfer pathway ET - Tab. 1; Fig. 2B, 4 (State 3u)
electron transfer system Electron transfer pathway ETS - Fig. 2B, 4 (electron transport chain)
elementary entity Entity Xs [x] single countable object of sample type s; Tab. 4
ET capacity ET capacity E varies rate; Tab. 1; Fig. 2
ET-excess capacity ET capacity E-P varies Fig. 2
flow, for O2 Flow IO2 [mol∙s-­1] system-related extensive quantity; Fig. 5
flux, for O2 Flux JO2 varies size-specific quantity; Fig. 5
flux control ratio Flux control ratio FCR 1 background/reference flux; Fig. 5
hyphenation Hyphenation - - Updates in comparison to Gnaiger 2019 MitoFit Preprint Arch
inorganic phosphate Phosphate Pi - Fig. 1C
inorganic phosphate carrier Phosphate carrier PiC - Fig. 1C
International Union of Pure and Applied Chemistry, IUPAC IUPAC IUPAC - [[[Cohen 2008 IUPAC Green Book |24]]]
International System of Units International System of Units SI - [[[Cohen 2008 IUPAC Green Book |24]]]
isolated mitochondria Isolated mitochondria imt - [11]
LEAK state LEAK respiration LEAK - Tab. 1; Fig. 2 (compare State 4)
LEAK respiration LEAK respiration L varies rate; Tab. 1; Fig. 2
living cells Living cells ce - Tab. 5 (intact cells)
mass, dry mass Body mass md [kg] Fig. 5 (dry weight)
mass, wet mass Body mass mw [kg] Fig. 5 (wet weight)
mass concentration of sample s in chamber Concentration Cms [kg∙L-1] Tab. 4
mass format Format m [kg] Tab. 4
mass of sample s in a mixture Mass ms [kg] SI: mass of pure sample mS
mass per single object Body mass MNX [kg∙x­1] Fig. 5; Tab. 4; SI: m(X); compare molar mass M(X)
MITOCARTA MITOCARTA
mitochondria or mitochondrial Mitochondria mt - Box 1
mitochondrial concentration Mitochondrial marker, Concentration CmtE = mtEV-1 [mtEU∙L-1] Tab. 4
mitochondrial content per X Mitochondrial marker mtENX [mtEU∙x­-1] mtENX = mtENX-1; Tab. 4
mitochondrial density per ms Mitochondrial marker, Density DmtE/ms [mtEU∙kg­-1] DmtE/ms=mtEms-1; Tab. 4
mitochondrial density per Vs Mitochondrial marker, Density DmtE/Vs [mtEU∙kg­-1] DmtE/Vs=mtEVs-1; Tab. 4
mitochondrial DNA Mitochondria mtDNA - Box 1
mitochondrial elementary marker Mitochondria mtE [mtEU] quantity of mt-marker; Tab. 4
mitochondrial elementary unit Mitochondria mtEU varies specific units for mt-marker; Tab. 4
mitochondrial inner membrane Mitochondrial inner membrane mtIM - Fig. 1; Box 1 (MIM)
mitochondrial outer membrane Mitochondrial outer membrane mtOM - Fig. 1; Box 1 (MIM)
mitochondrial preparations Mitochondrial preparations mt-prep - Tab. 5
mitochondrial recovery Mitochondrial recovery YmtE 1 fraction of mtE recovered from the tissue sample in imt-stock
mitochondrial yield Mitochondrial yield YmtE/ms [mtEU∙kg-1] mt-yield in imt-stock per mass of tissue sample; YmtE/ms=YmtEDmtE
MitoPedia MitoPedia, MitoPedia: Respiratory states
molar format Format n [mol] Tab. 6
molar mass Molar mass MB [kg∙mol-1] compare MNB [kg∙x-1]; SI M(X)
negative Protonmotive force neg - Fig. 4
normalization of rate Normalization of rate - - Tab. 4; Fig. 5
number of cells Count Nce [x] total cell count of living cells, Nce = Nvce + Ndce; Tab. 4, 5
number of dead cells Cell viability Ndce [x] non-viable cell count, loss of plasma membrane barrier function; Tab. 5
number of entities B Count NB [x] Tab. 4 [[[Cohen 2008 IUPAC Green Book |24]]]
number of entities X; count Count NX [x] ‘count’ is an SI quantity [11], but the counting unit [x] is not in the SI [95]; Tab. 4; Fig. 5
number of viable cells Cell viability Nvce [x] viable cell count, intact plasma membrane barrier function; Tab. 5
organisms Organism org - Tab. 5
oxidative phosphorylation Oxidative phosphorylation OXPHOS - Tab. 1
OXPHOS capacity OXPHOS capacity P varies rate; Tab. 1; Fig. 2
OXPHOS state OXPHOS capacity OXPHOS - Tab. 1; Fig. 2; OXPHOS-state distinguished from the process OXPHOS (State 3 at kinetically-saturating [ADP] and [Pi])
oxygen concentration Oxygen concentration cO2 = nO2-1 [mol∙L­-1] [O2]; Section 3.2
oxygen solubility Oxygen solubility SO2 [µmol·kPa-1] Section 2.6.3
oxygen flux, in reaction r Oxygen flux JrO2 varies Overview
pathway control state Pathway control state PCS - Section 2.2
permeability transition Permeability transition mtPT - Fig. 3; Section 2.4.3 (MPT)
permeabilized cells Permeabilized cells pce - experimental permeabilization of plasma membrane; Tab. 5
permeabilized muscle fibers Permeabilized muscle fibers pfi - Tab. 5
permeabilized tissue Permeabilized tissue pti - Tab. 5
phosphorylation of ADP to ATP Oxidative phosphorylation - Tab. 1, 2; Fig. 1, 4
phosphorylation efficiency Ergodynamic efficiency ε 1 Section 2.4.1
P»/O2 ratio Oxidative phosphorylation P»/O2 1 mechanistic YP»/O2, calculated from pump stoichiometries; Fig. 1c
positive positive Protonmotive force - Fig. 4
proton in the neg compartment Protonmotive force H+neg [x] Fig. 4
proton in the pos compartment proton in the positive compartment H+pos [x] Fig. 4
protonmotive force protonmotive force pmF [V] Overview; Tab. 1; Fig 1a, 2, 4
quantities, symbols, and units Quantities, symbols, and units - - An explanation of symbols and unit [x]
rate in ET state Electron transfer pathway E varies ET capacity; Tab. 1; Fig. 2, 4
rate in LEAK state LEAK respiration L varies Tab. 1: L(n), L(T), L(Omy); Fig. 2, 4
rate in OXPHOS state OXPHOS capacity P varies OXPHOS capacity; Tab.1; Fig. 2, 4
rate in ROX state Residual oxygen consumption Rox varies Overview; Tab. 1
residual oxygen consumption Residual oxygen consumption ROX; Rox - state ROX; rate Rox; Tab. 1
respiration Respirometry JrO2 varies rate of reaction r; Overview
respiratory state MitoPedia: Respiratory states - - Tab. 1, 3; Fig. 2, 4
respiratory supercomplex Supercomplex SCInIIInIVn - supramolecular assemblies with variable copy numbers (n) of CI, CIII and CIV; Box 1
sample in a mixture Sample s - diluted sample; Tab. 4, 5
steay state Steady state - - Section 2.5.6
substrate concentration at half-maximal rate Concentration c50 [mol∙L­-1] Section 2.1.2
substrate-uncoupler-inhibitor-titration Substrate-uncoupler-inhibitor titration SUIT - Section 2.2
system System - - Fig. 5
tissue homogenate Tissue homogenate thom - Tab. 5
unit elementary entity Entity UX [x] single countable object; Tab. 4, 5
uncoupling Uncoupler titrations - - Tab 2; Fig. 3
viable cells Viable cells vce - Tab. 5
volume format Format V [L] Tab. 6
volume of experimental chamber Volume V [L] liquid volume V including the sample s; Tab. 4, 7; Fig. 5
volume of sample s in a mixture Volume Vs [L] Tab. 5; Fig. 5


Authors: MitoEAGLE Task Group

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Erich Gnaiger
Chair COST Action CA15203 MitoEAGLE
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Discussion — updates — versions

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SI units

One year ago, on World Metrology Day (2019-May-20) the redefinition of the SI units came into force. Science faced one of the largest overhauls in history of scientific units. How to commemorate this event of groundbreaking innovation better than with the online publication of Mitochondrial physiology and with the launch of an innovative journal — Bioenergetics Communications.

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This BEC article was communicated as a preprint in MitoFit Preprint Archives
» Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v4. - »Bioblast link«


MitoPedia topics: BEC 


Labels: MiParea: Respiration, mt-Awareness 



Preparation: Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria  Enzyme: Marker enzyme  Regulation: Coupling efficiency;uncoupling, Flux control, mt-Membrane potential, Uncoupler  Coupling state: LEAK, OXPHOS, ET  Pathway: F, N, S, Gp, DQ, CIV, NS, Other combinations, ROX 


MitoFitPublication, MitoEAGLEPublication, Alternative oxidase, AMP, ADP, ATP, Adenylates, Amount, ATP yield, Respiration, Count, Mass, Concentration, Concentration, Cell viability, Charge number, Complex I, Complex II, Complex III, Complex IV, Concentration, Format, Count, Coupling control ratio, Coupling control state, Cell viability, Format, Electron transfer-pathway, Electron transfer-pathway, Entity, ET-capacity, Flow, Flux, Flux control ratio, Phosphate, Phosphate carrier, IUPAC, International System of Units, Isolated mitochondria, Living cells, LEAK-respiration, Format, MITOCARTA, MitoPedia, Mitochondria, Mitochondrial marker, Density, Mitochondrial inner membrane, Mitochondrial outer membrane, Mitochondrial preparations, Mitochondrial recovery, Mitochondrial yield, Molar mass, Protonmotive force, Normalization of rate, Cell viability, Organism, Oxidative phosphorylation, Oxygen concentration, Oxygen solubility, Oxygen flux, Pathway control state, Permeability transition, Permeabilized cells, Permeabilized muscle fibers, Permeabilized tissue, Ergodynamic efficiency, LEAK-respiration, OXPHOS-capacity, Residual oxygen consumption, Respiration, MitoPedia: Respiratory states, Supercomplex, Sample, Substrate-uncoupler-inhibitor-titration, Tissue homogenate, Uncoupler titrations, Volume