Zunica 2024 Mol Metab

From Bioblast
Publications in the MiPMap
Zunica ERM, Axelrod CL, Gilmore LA, Gnaiger E, Kirwan JP (2024) The bioenergetic landscape of cancer. Mol Metab 86:101966. https://doi.org/10.1016/j.molmet.2024.101966

Β» PMID: 38876266 Open Access

Zunica Elizabeth RM, Axelrod Christopher L, Gilmore L Anne, Gnaiger Erich, Kirwan John P (2024) Mol Metab

Abstract: Bioenergetic remodeling of core energy metabolism is essential to the initiation, survival, and progression of cancer cells through exergonic supply of adenosine triphosphate (ATP) and metabolic intermediates, as well as control of redox homeostasis. Mitochondria are evolutionarily conserved organelles that mediate cell survival by conferring energetic plasticity and adaptive potential. Mitochondrial ATP synthesis is coupled to the oxidation of a variety of substrates generated through diverse metabolic pathways. As such, inhibition of the mitochondrial bioenergetic system by restricting metabolite availability, direct inhibition of the respiratory Complexes, altering organelle structure, or coupling efficiency may restrict carcinogenic potential and cancer progression. Here, we review the role of bioenergetics as the principal conductor of energetic functions and carcinogenesis while highlighting the therapeutic potential of targeting mitochondrial functions.

β€’ Bioblast editor: Gnaiger E β€’ O2k-Network Lab: US LA Baton Rouge Noland RC, AT Innsbruck Oroboros


Labels: MiParea: Respiration, mt-Structure;fission;fusion, mtDNA;mt-genetics, mt-Medicine, Pharmacology;toxicology  Pathology: Cancer  Stress:Cell death, Oxidative stress;RONS 



Regulation: Aerobic glycolysis, Coupling efficiency;uncoupling, mt-Membrane potential, Fatty acid 



Metformin, Warburg effect, Crabtree effect 


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