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Varela-Lopez 2016 J Gerontol A Biol Sci Med Sci

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Varela-Lopez A, Bullon P, Battino M, Ramirez-Tortosa MC, Ochoa JJ, Cordero MD, Ramirez-Tortosa CL, Rubini C, Zizzi A, Quiles JL (2016) Coenzyme Q protects against age-related alveolar bone loss associated to n-6 polyunsaturated fatty acid rich-diets by modulating mitochondrial mechanisms. J Gerontol A Biol Sci Med Sci 71:593-600.

Β» PMID: 26219851

Varela-Lopez A, Bullon P, Battino M, Ramirez-Tortosa MC, Ochoa JJ, Cordero MD, Ramirez-Tortosa CL, Rubini C, Zizzi A, Quiles JL (2016) J Gerontol A Biol Sci Med Sci

Abstract: An age-dependent model of the periodontium was reproduced to evaluate the effect of life-long feeding on a low coenzyme Q10 dosage in n-6, n-3 polyunsaturated fatty acid or monounsaturated fatty acid-based diets on periodontal tissues of young and old rats. Results shown that exacerbated age-related alveolar bone loss previously associated to n-6 polyunsaturated fatty acid diet was attenuated by coenzyme Q10 Gene expression analysis suggests that involved mechanisms might be related to a restored capacity of mitochondria to adapt to aging in gingival cells from rats fed on n-6 polyunsaturated fatty acid. In particular, this could be due to an age-related increase of the rate of mitochondrial biogenesis and a better oxidative and respiratory balance in these animals. From the nutritional and clinical point of view, it is noteworthy that supplementation with coenzyme Q10 could counteract the negative effects of n-6 polyunsaturated fatty acid on alveolar bone loss (a major feature of periodontitis) associated to age.

Β© The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. β€’ Keywords: Biogenesis, Electron transport chain, Fish oil, Sunflower oil, Virgin olive oil


Labels: Pathology: Aging;senescence 

Organism: Rat