US VA Richmond Bennett JP

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US VA Richmond Bennett JP

Oroboros O2k-Network

O2k-Network
O2k-Network Lab Virginia Commonwealth University

Power-O2k: US VA Richmond Virginia Commonwealth Univ

Address P.O. Box 980599

1101 East Marshall Street, 23298-0599

City Richmond
State/Prov Virginia (VA)
Country USA
Weblink
Contact Bennett James P
Team Keeney Paula, Miller Bradley, Ravindar Thoma, Sanchez Victoria, Trimmer Patricia, Young Kisha
Team previous Iyer Shilpa, Mohanakumar Kochupurackal P
Status O2k 2007-
Oroboros Events MitoEAGLE 2017 CZ, MiPschool 2017, MiP2014, IOC72, Bioblast 2012, IOC54, IOC32
Topics Mitochondrial diseases, Gene therapy


O2k-Publications

 PublishedReference
Ladd 2017 Brain Res2017Ladd AC, Brohawn DG, Thomas RR, Keeney PM, Berr SS, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Bennett JP (2017) RNA-seq analyses reveal that cervical spinal cords and anterior motor neurons from amyotrophic lateral sclerosis subjects show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency. Brain Res 1667:74-83.
Thomas 2016 Neurodegeneration Therapeutics2016Thomas RR, Keeney PM, Berr SB, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Brohawn DG, Bennett JP (2016) Recombinant human TFAM stimulates rat brain, rat cervical spinal cord and human neural stem cell mitochondrial bioenergetics. Neurodegeneration Therapeutics p41.
Iyer 2012 Hum Gene Ther2012Iyer S, Bergquist K, Young K, Gnaiger E, Rao RR, Bennett JP Jr (2012) Mitochondrial gene therapy improves respiration, biogenesis and transcription in G11778A Leber’s hereditary optic neuropathy and T8993G Leigh’s syndrome cells. Hum Gene Ther 23:647-57.
Thomas 2011 Mitochondrion2011Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP Jr (2011) Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin. Mitochondrion 11:108-18.
Iyer 2009 Mitochondrion2009Iyer S, Thomas R, Portell F, Dunham L, Quigley C, Bennett JP (2009) Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression. Mitochondrion 9:196-203.
Keeney 2009 Hum Gene Ther2009Keeney PM, Quigley CK, Dunham LD, Papageorge CM, Iyer S, Thomas RR, Schwarz KM, Trimmer PA, Khan SM, Portell FR, Bergquist KE, Bennett JP (2009) Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model. Hum Gene Ther 20:897-907.
Keeney 2009 Exp Neurol2009Keeney PM, Dunham LD, Quigley CK, Morton SL, Bergquist KE, Bennett JP (2009) Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships. Exp Neurol 220:374-82.
Borland 2009 Biochim Biophys Acta2009Borland MK, Mohanakumar KP, Rubinstein JD, Keeney PM, Xie J, Capaldi R, Dunham LD, Trimmer PA, Bennett JP Jr (2009) Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues. Biochim Biophys Acta 792: 68-74.
Iyer 2008 Nature Precedings2008Iyer S, Thomas R, Portell F, Dunham L, Quigley C, Bennett JP (2008) Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression in G11778A leber’s hereditary optic neuropathy cybrid cells. Nature Precedings: hdl:10101/npre.2008.2084.1

O2k-Abstracts

update please