US NC Winston-Salem Molina AJA

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US NC Winston-Salem Molina AJA

Oroboros O2k-Network

O2k-Network
O2k-Network Lab
Anthony Molina (l) Erich Gnaiger (r) MiPschool Greenville 2015
J. Paul Sticht Center on Aging

Department of Internal Medicine

Section on Gerontology and Geriatric Medicine

Wake Forest School of Medicine

See also: US CA San Diego Molina AJA

Address Medical Center Boulevard, NC 27157
City Winston-Salem
State/Prov North Carolina (NC)
Country USA
Weblink
Contact Molina Anthony JA
Team Bharadwaj Manish, Dozier Stephen, Eggebeen Joel, Kitzman Dalane W, Kramer Philip A
Team previous Tyrrell Daniel
Status 7 Power-O2k 2014-
Oroboros Events MitoFit Science Camp 2016, IOC106, IOC104
Topics


O2k-Publications

 PublishedReference
Douros 2019 JCI Insight2019Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688.
Tyrrell 2016 Redox Biol2016Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ (2016) Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 10:65-77.

O2k-Abstracts

 PublishedReference
Amick 2017 MiPschool Obergurgl2017
Amick picture.jpg
Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates.
Collins 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.

UPBEAT project

The following webpage summarizes our current Aging Center projects: Aging Center projects
US NC Winston-Salem Molina AJA.png



UPBEAT- Understanding the Physiology and BioEnergetics of Aging
Age-related bioenergetic decline underlies numerous features of aging, including the development of age-related diseases and disorders. To date, there is a limited understanding of how mitochondrial bioenergetics changes in the context of normal human aging. The goal of UPBEAT is to address this gap in knowledge and to generate a database of bioenergetic profiles from healthy individuals across a spectrum of ages. A key feature of UPBEAT is its design to serve as a healthy control group for ongoing and future research projects. For example, the role of mitochondrial bioenergetics in in several age-related diseases is currently being investigated by comparing data from patients and age-matched UPBEAT participants.
Highly comprehensive bioenergetic profiling is being achieved by respirometry of circulating cells and biopsied skeletal muscle tissue using complementary approaches and protocols. In addition to standard clinical measures, analyses of physical ability and exercise capacity are being conducted. Current recruitment is focused on healthy older adults; younger age groups will follow.


Principal Investigator:
Anthony J.A. Molina. PhD
Wake Forest School of Medicine


-This study is supported by the American Heart Association and the National Institute on Aging.
-Additional support and technical expertise provided by Oroboros Instruments (Innsbruck, Austria).


To download the UPBEAT project summary press here.



K-Regio MitoFit

MitoFit

Strategic partner of the K-Regio MitoFit project.


Visiting scientist in the Oroboros MitoFit Laboratory

O2k-Network
Anthony JA Molina : Visiting scientist at the OROBOROS MitoFit Laboratory from October 04 to October 06 2015.
Daniel Tyrrell: Visiting scientist at the OROBOROS MitoFit Laboratory from October 04 to October 06 2015.