From Bioblast
US LA Baton Rouge Noland RC
| O2k-Network Lab | Pennington Biomedical Research Center |
|---|---|
| Address | 6400 Perkins Road, 70808 |
| City | Baton Rouge |
| State/Prov | Louisiana (LA) |
| Country | USA |
| Weblink | Integrated Physiology and Molecular Medicine Laboratory |
| Contact | Axelrod Christopher L |
| Team | Zunica Elizabeth RM, Noland Robert C |
| Team previous | Darcy Johannsen, Davuluri Gangarao, Worsham E, Dantas Wagner S |
| Status | 6 Power-O2k incl. 2 NextGen-O2k 2012- |
| Oroboros Events | IOC163 Schroecken AT, IOC162 Schroecken AT, IOC141, IOC68 |
| Topics | Bioenergetic adaptations in obesity, Type 2 diabetes, MASLD, Cancer |
O2k-Publications
| Published | Reference | |
|---|---|---|
| Wall 2021 Dis Model Mech | 2021 | Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE (2021) CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech 14:dmm048603. |
| Axelrod 2021 EMBO Mol Med | 2021 | Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088. |
| King 2021 J Biol Chem | 2021 | King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, Lรณpez-Domรจnech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196. |
| Zunica 2021 Cancer Metab | 2021 | Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36. |
| Kumar 2021 JCI Insight | 2021 | Kumar A, Welch N, Mishra S, Bellar A, Silva RN, Li L, Singh SS, Sharkoff M, Kerr A, Chelluboyina AK, Sekar J, Attaway AH, Hoppel C, Willard B, Davuluri G, Dasarathy S (2021) Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence. JCI Insight 6:e154089. |
| Kumar 2019 Free Radic Biol Med | 2019 | Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99. |
| Park 2015 Proc Natl Acad Sci USA | 2015 | Park JH, Kang HJ, Lee YK, Kang H, Kim J, Chung JH, Chang JS, McPherron AC, Lee SB (2015) Inactivation of EWS reduces PGC-1ฮฑ protein stability and mitochondrial homeostasis. Proc Natl Acad Sci USA 112:6074-9. |
O2k-Abstracts
| Published | Reference | |
|---|---|---|
| Dantas 2024 Abstract IOC163 | 2024 | Dantas WS, Heintz EC, Zunica ERM, Dousay M, Davuluri G, Yu CS, Murphy MP, Axelrod CL, Kirwan JP (2024) Mito-Q supplementation reverses sarcopenic obesity in aged mice by restoring mitochondrial function and enhancing antioxidant response. Mitochondr Physiol Network 28.11. |
| Axelrod 2022 Abstract Bioblast | 2022 | 3.6. ยซ5 minยป   |
| Axelrod 2019 Abstract IOC141 | 2019 | Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02. |
