Template:Publications: N-pathway control state

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 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Gnaiger 2020 MitoPathways2020Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2 (in prep).LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Szibor 2020 J Biol Chem2020Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97.LEAK
OXPHOS
N
S
Gp
CIV
NS
ROX
Isolated mitochondria
Intact cells
MouseNervous system
Chen 2020 Biochim Biophys Acta Mol Basis Dis2020Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Jayakumari 2020 J Diabetes2020Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaHumanHeart
Coppin 2020 Cell Death Dis2020Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanIslet cell;pancreas;thymus
Endothelial;epithelial;mesothelial cell
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis2020Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondria
Intact cells
RatLiver
Nervous system
Liu 2020 Am J Physiol Heart Circ Physiol2020Liu R, Jagannathan R, Sun L, Li F, Yang P, Lee J, Negi V, Perez-Garcia EM, Shiva S, Yechoor VK, Moulik M (2020) Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol 319:H89-99.LEAK
OXPHOS
F
N
NS
Isolated mitochondriaMouseHeart
Ehrlicher 2020 FASEB J2020Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18.LEAK
OXPHOS
ET
F
N
S
NS
Isolated mitochondriaMouseSkeletal muscle
Sharma 2020 Integr Cancer Ther2020Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437.LEAK
OXPHOS
N
S
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Irion 2020 Stem Cells Int2020Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, de Carvalho ACC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatHeart
Hafstad 2020 Antioxidants (Basel)2020Hafstad AD, Hansen SS, Lund J, Santos CXC, Boardman NT, Shah AM, Aasum E (2020) NADPH oxidase 2 mediates myocardial oxygen wasting in obesity. Antioxidants (Basel) 9:E171.LEAK
OXPHOS
F
N
Isolated mitochondriaMouseHeart
Briones-Herrera 2020 Free Radic Biol Med2020Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.LEAK
OXPHOS
F
N
S
NS
ROX
Isolated mitochondriaRatKidney
MitoEAGLE muscle 12020Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08LEAK
OXPHOS
ET
N
NS
S
ROX
Permeabilized tissueHumanSkeletal muscle
Purhonen 2020 Nat Commun2020Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseLiver
Kidney
Yadav 2020 Cell Death Dis2020Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized cellsHumanHeart
Stem cells
Lantier 2020 Diabetes2020Lantier Louise, Williams Ashley S, Williams Ian M, Guerin Amanda, Bracy Deanna P, Goelzer Mickael, Foretz Marc, Viollet Benoit, Hughey Curtis C, Wasserman David H (2020) Reciprocity between skeletal muscle AMPK deletion and insulin action in diet-induced obese mice. Diabetes [Epub ahead of print].OXPHOSNPermeabilized tissueMouseSkeletal muscle
Pena 2020 Int J Chronic Dis2020Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Severo 2020 Life Sci2020Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
McLaughlin 2020 Sci Rep2020McLaughlin KL, Kew KA, McClung JM, Fisher-Wellman KH (2020) Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase. Sci Rep 10:3603.LEAKF
N
S
Isolated mitochondriaMouseHeart
Skeletal muscle
Oellermann 2020 Sci Rep2020Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202.LEAK
OXPHOS
ET
N
S
NS
HomogenateCrustaceansHeart
Makrecka-Kuka 2020 Cardiovasc Drugs Ther2020Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther [Epub ahead of print].OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseHeart
Duong 2020 Mitochondrion2020Duong QV, Hoffman A, Zhong K, Dessinger MJ, Zhang Y, Bazil JN (2020) Calcium overload decreases net free radical emission in cardiac mitochondria. Mitochondrion 51:126-39.LEAK
OXPHOS
ET
F
N
S
Isolated mitochondriaGuinea pigHeart
Gvozdjakova 2020 Diagnostics (Basel)2020Gvozdjakova Anna, Sumbalova Zuzana, Kucharska Jarmila, Komlosi Maria, Rausova Zuzana, Vancova Olga, Szamosova Monika, Mojto Viliam(2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:E176.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Politis-Barber 2020 Am J Physiol Endocrinol Metab2020Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab [Epub ahead of print].LEAK
OXPHOS
F
N
Gp
NS
Permeabilized cellsMouseFat
Cornelissen 2020 Hum Mol Genet2020Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanFibroblast
Li Puma 2020 Am J Physiol Regul Integr Comp Physiol2020Li Puma Lance C, Hedges Michael, Heckman Joseph M, Mathias Alissa B, Engstrom Madison R, Brown Abigail B, Chicco Adam J (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:R972-80.LEAK
OXPHOS
N
NS
Permeabilized tissue
Homogenate
Isolated mitochondria
MouseHeart
Skeletal muscle
Bertero 2020 Circ Res2020Bertero E, O'Rourke B, Maack C (2020) Mitochondria do not survive calcium overload during transplantation. Circ Res 126:784-86.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Zussman 2020 J Autoimmun2020Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437.LEAK
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueHumanGenital
Xia 2020 Biomed Res Int2020Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Fuchs 2020 J Funct Foods2020Fuchs C, Bakuradze T, Steinke R, Grewal R, Eckert GP, Richling E (2020) Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. J Funct Foods 70:103988.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanLiver
Tepp 2020 Biochim Biophys Acta Gen Subj2020Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMouseHeart
Skeletal muscle
Keller 2020 Oxid Med Cell Longev2020Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629.LEAK
OXPHOS
ET
N
NS
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Ost 2020 EMBO Rep2020Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Venediktova 2020 Mitochondrion2020Venediktova NI, Mashchenko OV, Talanov EY, Belosludtseva NV, Mironova GD (2020) Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism. Mitochondrion [Epub ahead of print].LEAK
OXPHOS
N
NS
Isolated mitochondriaRatLiver
Dawid 2020 Biochim Biophys Acta Bioenerg2020Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg [Epub ahead of print].LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
NS
ROX
Permeabilized cells
Isolated mitochondria
Intact cells
Human
Mouse
Nervous system
HEK
Mohsin 2020 Arch Biochem Biophys2020Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299.LEAK
OXPHOS
N
S
Permeabilized cellsRatSkeletal muscle
Ulgherait 2020 Nat Commun2020Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaDrosophila
Hraoui 2020 J Exp Biol2020Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMolluscsLung;gill
Brand 2020 J Clin Med2020Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized cellsHumanLymphocyte
Jian 2020 Cell Metab2020Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized cellsMouseLiver
Liu 2020 Cell Death Dis2020Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized tissueMouseEndothelial;epithelial;mesothelial cell
Yurre 2020 Arq Bras Cardiol2020Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol [Epub ahead of print].LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseHeart
Fisher 2020 Placenta2020Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaHumanGenital
Kuzniewska 2020 EMBO Rep2020Kuzniewska B, Cysewski D, Wasilewski M, Sakowska P, Milek J, Kulinski TM, Winiarski M, Kozielewicz P, Knapska E, Dadlez M, Chacinska A, Dziembowski A, Dziembowska M (2020) Mitochondrial protein biogenesis in the synapse is supported by local translation. EMBO Rep [Epub ahead of print].LEAK
ET
N
S
Permeabilized cellsHuman
Mouse
Nervous system
HEK
Carvalho 2020 BMC Nutr2020Carvalho E, Adams SH, Boersheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissuePigLiver
Groennebaek 2020 Cells2020Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Sowton 2020 Mol Genet Metab Rep2020Sowton AP, Padmanabhan N, Tunster SJ, McNally BD, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED (2020) Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Mol Genet Metab Rep 23:100580.LEAK
OXPHOS
N
NS
HomogenateMouseLiver
Schoepf 2020 Nat Commun2020Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 11:1487.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
HumanGenital
Other cell lines
Dawson 2020 J Exp Biol2020Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized tissueFishesLung;gill
Rebane-Klemm 2020 Cancers (Basel)2020Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanEndothelial;epithelial;mesothelial cell
Falcao-Tebas 2020 J Physiol2020Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Doig 2020 Skelet Muscle2020Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Alston 2020 Am J Hum Genet2020Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized cells
Intact cells
HumanFibroblast
D'Souza 2020 Nutrients2020D'Souza K, Mercer A, Mawhinney H, Pulinilkunnil T, Udenigwe CC, Kienesberger PC (2020) Whey peptides stimulate differentiation and lipid metabolism in adipocytes and ameliorate lipotoxicity-induced insulin resistance in muscle cells. Nutrients 12:E425.LEAK
ET
F
N
Permeabilized cellsMouseSkeletal muscle
Fat
Feng 2020 Int J Biol Macromol2020Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol 155:524-34.LEAK
OXPHOS
N
S
ROX
Isolated mitochondriaHexapods
Krajcova 2020 PLOS ONE2020Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142.LEAK
OXPHOS
ET
N
S
NS
ROX
Homogenate
Isolated mitochondria
HumanHeart
Zhang 2020 Chemosphere2020Zhang Y, Li Y, Feng Q, Shao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere 248:126009.LEAK
OXPHOS
N
S
ROX
Isolated mitochondriaHexapods
Alexopoulos 2020 Nat Commun2020Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun 11:2397.LEAKNPermeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Fat
Friederich-Persson 2020 Am J Physiol Renal Physiol2020Friederich-Persson M, Persson P (2020) Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats. Am J Physiol Renal Physiol 318:F683-88.LEAK
OXPHOS
N
Gp
Isolated mitochondriaRatKidney
Tichanek 2020 Sci Rep2020Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateMouseNervous system
Vaccari 2020 Eur J Appl Physiol2020Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Stankova 2020 Int J Mol Sci2020Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.LEAK
OXPHOS
F
N
S
Gp
NS
ROX
HomogenateMouseLiver
Song 2020 Life Sci2020Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. Life Sci 252:117633.LEAK
OXPHOS
ET
F
N
NS
HomogenateMouseLiver
Pereira 2020 PLoS One2020Pereira GC, Lee L, Rawlings N, Ouwendijk J, Parker JE, Andrienko TN, Henley JM, Halestrap AP (2020) Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia. PLoS One 15:e0234653.LEAK
OXPHOS
NIsolated mitochondriaRatHeart
Matsuo 2020 Am J Physiol Endocrinol Metab2020Matsuo FS, Araújo PHC, Mota RF, Carvalho AJR, Queiroz MS, Almeida BB, Ferreira KCOS, Metzner RJM, Ferrari GD, Alberici LC, Osako MK (2020) RANKL induces beige adipocyte differentiation in preadipocytes. Am J Physiol Endocrinol Metab 318:E866-77.LEAK
OXPHOS
NPermeabilized cellsMouseFat
Dirks 2020 J Physiol2020Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Skemiene 2020 J Bioenerg Biomembr2020Skemiene K, Pampuscenko K, Rekuviene E, Borutaite V (2020) Protective effects of anthocyanins against brain ischemic damage. J Bioenerg Biomembr 52:71-82.LEAK
OXPHOS
NIsolated mitochondriaRatNervous system
Buch 2020 FASEB J2020Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Evinova 2020 J Membr Biol2020Evinova A, Cizmarova B, Hatokova Z, Racay P (2020) High‑resolution respirometry in assessment of mitochondrial function in neuroblastoma SH‑SY5Y intact cells. J Membr Biol 253:129-36.LEAK
ROUTINE
ET
N
S
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Baggio 2020 Neurotoxicology2020Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafishNervous system
Barsottini 2020 Commun Biol2020Barsottini MRO, Copsey A, Young L, Baroni RM, Cordeiro AT, Pereira GAG, Moore AL (2020) Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa. Commun Biol 3:263.OXPHOSF
N
S
CIV
Protists
No 2020 Pflugers Arch2020No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93.LEAK
OXPHOS
N
NS
Permeabilized tissueRatHeart
Eshima 2020 J Appl Physiol (1985)2020Eshima H, Siripoksup P, Mahmassani ZS, Johnson JM, Ferrara PJ, Verkerke ARP, Salcedo A, Drummond MJ, Funai K (2020) Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice. J Appl Physiol (1985) [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseSkeletal muscle
Silaidos 2020 Mitochondrion2020Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Locatelli 2020 FASEB J2020Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondria
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Cruz 2020 Drug Alcohol Depend2020Cruz JV, Maba IK, Correia D, Kaziuk FD, Cadena SMSC, Zampronio AR (2020) Intermittent binge-like ethanol exposure during adolescence attenuates the febrile response by reducing brown adipose tissue thermogenesis in rats. Drug Alcohol Depend 209:107904.LEAK
OXPHOS
NIsolated mitochondriaRatFat
Reutzel 2020 Oxid Med Cell Longev2020Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.LEAK
ET
OXPHOS
N
S
CIV
ROX
Isolated mitochondriaMouseNervous system
Cassereau 2020 Exp Neurol2020Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsHumanFibroblast
Larsen 2020 Acta Physiol (Oxf)2020Larsen FJ, Schiffer TA, Zinner C, Willis SJ, Morales-Alamo D, Calbet J5, Boushel R, Holmberg HC (2020) Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake. Acta Physiol (Oxf) 229:e13463.OXPHOSN
NS
Isolated mitochondriaHumanSkeletal muscle
Brunetta 2020 J Physiol2020Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol [Epub ahead of print].LEAK
OXPHOS
N
NS
Permeabilized tissueMouseFat
Kanellopoulos 2020 Cell2020Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateDrosophilaNervous system
Other cell lines
Dulac 2020 J Physiol2020Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol [Epub ahead of print].LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Schneider 2020 PLoS One2020Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710.LEAK
OXPHOS
F
N
S
CIV
NS
ROX
Permeabilized tissueRatHeart
Hassan 2020 MitoFit Preprint Arch2020Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. MitoFit Preprint Arch 2020.3 doi:10.26124/mitofit:200003.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHuman
Close 2020 Cells2020Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J (2020) Disruption of beta-cell mitochondrial networks by the orphan nuclear receptor Nor1/Nr4a3. Cells 9:E168.LEAK
ROUTINE
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
RatIslet cell;pancreas;thymus
BEC 2020.1 doi10.26124bec2020-0001.v12020Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1.LEAK
OXPHOS
ET
F
N
S
Gp
DQ
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Hayes 2020 Nutrients2020Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
ROX
Permeabilized cells
Intact cells
HumanHeLa
Rondot 2020 Thesis2020Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueHexapodsSkeletal muscle
Janowska 2020 Toxicol In Vitro2020Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794.LEAK
ROUTINE
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Woodhead 2020 J Appl Physiol (1985)2020Woodhead JST, D'Souza RF, Hedges CP, Wan J, Berridge MV, Cameron-Smith D, Cohen P, Hickey AJR, Mitchell CJ, Merry TL (2020) High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol (1985) 128:1346-54.OXPHOSN
NS
Permeabilized tissueHumanSkeletal muscle
Jespersen 2020 Sci Rep2020Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueRatHeart
Remie 2020 Am J Clin Nutr2020Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Vulczak 2020 Cells2020Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628.LEAK
OXPHOS
ET
N
ROX
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Al-Azab 2020 FEBS J2020Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J [Epub ahead of print].LEAK
ROUTINE
OXPHOS
ET
N
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
Bloise 2020 Thyroid2020Bloise FF, Santos AT, Brito JT, Andrade CBV, Oliveira TS, Souza AF, Fontes KN, Silva JD, Blanco NG, Silva PL, Rocco PRM, Fliers E, Boelen A, da-Silva WS, Ortiga-Carvalho TM (2020) Sepsis impairs thyroid hormone signaling and mitochondrial function in the mouse diaphragm. Thyroid [Epub ahead of print].LEAK
OXPHOS
ET
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Schleier 2020 J Cardiovasc Transl Res2020Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res [Epub ahead of print].LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseHeart
Hartmann 2020 Free Radic Res2020Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueRatSkeletal muscle
Liepinsh 2020 Physiol Rep2020Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489.LEAK
ROUTINE
OXPHOS
F
N
CIV
Permeabilized cells
Intact cells
HumanBlood cells
Fuller 2020 J Appl Physiol (1985)2020Fuller KNZ, McCoin CS, Allen J, Bell-Glenn S, Koestler DC, Dorn Ii GW, Thyfault JP (2020) Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice. J Appl Physiol (1985) 128:1251-61.LEAK
OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
Wang 2020 J Mol Med (Berl)2020Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61.LEAK
OXPHOS
N
ROX
Isolated mitochondriaMouseHeart
Franco 2020 bioRxiv2020Franco JLM, Genoula M, Corral D, Duette G, Ferreyra M, Maio M, Dolotowicz MB, Aparicio-Trejo OE, Patiño-Martínez E, Fuentes F, Soldan V, Moraña EJ, Palmero D, Ostrowski M, Schierloh P, Sánchez-Torres C, Hernández-Pando R, Pedraza-Chaverri J, Rombouts Y, Layre E, Hudrisier D, Vérollet C, Neyrolles O, Sasiain MC, Lugo-Villarino G, Balboa L (2020) Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity. bioRxiv doi: https://doi.org/10.1101/2020.03.23.001818 .LEAK
ROUTINE
N
S
CIV
ROX
Intact cellsHumanMacrophage-derived
Baxter 2020 Elife2020Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateMouseHeart
Khamoui 2020 Physiol Genomics2020Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16.LEAK
OXPHOS
ET
N
NS
Intact cellsMouseLiver
Fecker 2020 Biomolecules2020Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 10:E818.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Woessner 2020 J Appl Physiol (1985)2020Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Miotto 2020 Am J Physiol Endocrinol Metab2020Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab [Epub ahead of print].OXPHOS
LEAK
N
NS
F
Permeabilized tissueRatSkeletal muscle
Pajuelo-Reguera 2020 Cells2020Pajuelo Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443.OXPHOS
ET
N
S
Gp
NS
Other combinations
Permeabilized cells
Oxidase;biochemical oxidation
HumanHEK
Gnad 2020 Cell Metab2020Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab [Epub ahead of print].LEAK
OXPHOS
ET
N
S
Permeabilized tissueMouseSkeletal muscle
McCommis 2020 bioRxiv2020McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, Todd King M, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Ketogenic diet prevents heart failure from defective mitochondrial pyruvate metabolism. bioRxiv doi: https://doi.org/10.1101/2020.02.21.959635 .LEAK
OXPHOS
F
N
Isolated mitochondriaMouseHeart
Roginski 2020 Biochim Biophys Acta Mol Basis Dis2020Roginski AC, Wajner A, Cecatto C, Wajner SM, Castilho RF, Wajner M, Amaral AU (2020) Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. Biochim Biophys Acta Mol Basis Dis 1866:165682.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cells
Isolated mitochondria
Homogenate
RatHeart
Other cell lines
Xiong 2020 Biomed Pharmacother2020Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsHuman
Rat
Endothelial;epithelial;mesothelial cell
Maeda 2020 J Cell Mol Med2020Maeda H, Kami D, Maeda R, Murata Y, Jo JI, Kitani T, Tabata Y, Matoba S, Gojo S (2020) TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes. J Cell Mol Med 24:5007-20.LEAK
ROUTINE
OXPHOS
ET
N
ROX
Isolated mitochondria
Intact cells
RatHeart
Liu 2020 J Clin Invest2020Liu L, Ding C, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z (2020) Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest [Epub ahead of print].LEAK
OXPHOS
NPermeabilized tissueMouseSkeletal muscle
MitoEAGLE blood cells 12020Åsander Frostner Eleonor*, Aburel Oana M*, Avram Vlad F*, Calabria Elisa, Castelo Rueda Maria Paulina*, Chamkha Imen*, Čižmárová Beata, Danila Maria-Daniela*, Doerrier Carolina*, Eckert Gunter P*, Ehinger Johannes K, Elmer Eskil*, Garcia-Souza Luiz F*, Gnaiger Erich*, Hoppel Florian*, Karabatsiakis Alexander*, Keppner Gloria, Kidere Dita*, Krako Jakovljević Nina, Labieniec-Watala Magdalena*, Lelcu Theia*, Micankova Petra, Michalak Slawomir*, Molina Anthony JA*, Pavlovic Kasja, Pichler Irene*, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina*, Silaidos Carmina*, Sjövall Fredrik*, Sobotka Ondrej*, Sumbalova Zuzana*, Swiniuch Daria, Vernerova Andrea*, Volani Chiara*, Vujacic-Mirski Ksenija*, Watala Cezary* (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *ConfirmedLEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Almoiliqy 2020 Acta Pharmacol Sin2020Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin [Epub ahead of print].LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
RatEndothelial;epithelial;mesothelial cell
Krabbendam 2020 Cell Death Dis2020Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263.LEAK
OXPHOS
N
S
Isolated mitochondriaMouseNervous system
Ferreira 2020 PLoS Genet2020Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseLiver
Keppner 2020 Thesis2020Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Szibor 2020 J Cell Mol Med2020Szibor Marten, Schreckenberg Rolf, Gizatullina Zemfira, Dufour Eric, Wiesnet Marion, Dhandapani Praveen Kumar, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Nyman Tuula A, Gaertner Ulrich, Hall Andrew R, Pell Victoria, Viscomi Carlo, Krieg Thomas, Murphy Michael P, Braun Thomas, Gellerich Frank Norbert, Schlueter Klaus-Dieter, Jacobs Howard T(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48.LEAK
OXPHOS
N
S
CIV
Permeabilized tissue
Isolated mitochondria
MouseHeart
Piel 2020 PLoS One2020Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanLiver
Platelet
Dubinin 2020 Biochim Biophys Acta Bioenerg2020Dubinin MV, Talanov EY, Tenkov KS, Starinets VS, Mikheeva IB, Belosludtsev KN (2020) Transport of Ca2+ and Ca2+-dependent permeability transition in heart mitochondria in the early stages of duchenne muscular dystrophy. Biochim Biophys Acta Bioenerg [Epub ahead of print].LEAK
OXPHOS
NIsolated mitochondriaMouseHeart
Frambach 2020 Biochim Biophys Acta Mol Basis Dis2020Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727.LEAK
OXPHOS
F
N
S
Gp
CIV
Other combinations
ROX
Permeabilized tissueMouseSkeletal muscle
Andrade 2020 Nutr Metab Cardiovasc Dis2020Andrade D, Oliveira G, Menezes L, Nascimento AL, Carvalho S, Stumbo AC, Thole A, Garcia-Souza É, Moura A, Carvalho L, Cortez E (2020) Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis 30:151-61.LEAK
OXPHOS
F
N
NS
Permeabilized tissueMouseHeart
Monaco 2020 Am J Physiol Endocrinol Metab2020Monaco CMF, Bellissimo CA, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ (2020) Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol Endocrinol Metab 318:E44-E51.OXPHOSN
S
Permeabilized tissueHumanSkeletal muscle
Anderson 2020 Cells2020Anderson Vulczak, de Oliveira Souza Anderson, Ferrari Gustavo Duarte, Caleiro Seixas Azzolini Ana Elisa, Pereira-da-Silva Gabriela, Alberici Luciane Carla (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:628.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissueMouse
Aparicio-Trejo 2020 Free Radic Biol Med2020Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.LEAK
OXPHOS
F
N
S
ROX
Isolated mitochondriaRatKidney
Gruenig 2020 Biochem Pharmacol2020Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860.LEAK
OXPHOS
ET
N
S
DQ
CIV
ROX
Isolated mitochondriaMouseLiver
Pham 2020 Eur J Appl Physiol2020Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Vega 2020 Physiol Rep2020Vega RB, Brouwers B, Parsons SA, Stephens NA, Pino MF, Hodges A, Yi F, Yu G, Pratley RE, Smith SR, Sparks LM (2020) An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. Physiol Rep 8:e14416.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Macedo 2020 FASEB J2020Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J [Epub ahead of print].LEAK
OXPHOS
F
N
CIV
ROX
Intact organism
Isolated mitochondria
Caenorhabditis elegans
Peruzzotti-Jametti 2020 bioRxiv2020Peruzzotti-Jametti L, Bernstock JD, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Kittel A, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2020) Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells. bioRxiv doi: https://doi.org/10.1101/2020.01.29.923441 .LEAKN
S
Gp
CIV
ROX
Permeabilized cellsMouseStem cells
Stepanova 2020 Methods Cell Biol2020Stepanova Anna, Galkin Alexander (2020) Measurement of mitochondrial H2O2 production under varying O2 tensions. Methods Cell Biol 155:273-93.LEAK
OXPHOS
S
N
Gp
Isolated mitochondriaMouseNervous system
De-Souza 2020 J Biol Chem2020De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.LEAK
OXPHOS
N
Gp
NS
ROX
Isolated mitochondria
Intact cells
Caenorhabditis elegans
Saccharomyces cerevisiae
Cubizolle 2020 J Cell Mol Med2020Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P (2020) Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal. J Cell Mol Med 24:5057-69.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized cellsRatEndothelial;epithelial;mesothelial cell
Zhou 2020 Biomed Pharmacother2020Zhou J, Zhang Y, Li S, Zhou Q, Lu Y, Shi J, Liu J, Wu Q, Zhou S (2020) Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway. Biomed Pharmacother 129:110351.LEAK
OXPHOS
NIsolated mitochondriaMouseLiver
Grewal 2020 Exp Neurol2020Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Boel 2020 J Exp Biol2020Boël M, Romestaing C, Duchamp C, Veyrunes F, Renaud S, Roussel D, Voituron Y (2020) Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. J Exp Biol 223:jeb215558.LEAK
ET
N
NS
Permeabilized tissueMouseSkeletal muscle
MiPNet18.05 Amplex-Mouse-heart2019-06-24
O2k-Protocols
O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate.
LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Cannon 2019 J Appl Physiol (1985)2019Cannon DT, Rodewohl L, Adams V, Breen EC, Bowen TS (2019) Skeletal myofiber VEGF deficiency leads to mitochondrial, structural and contractile alterations in mouse diaphragm. J Appl Physiol (1985) 127:1360-69.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Devaux 2019 Front Physiol2019Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis maintains the function of brain mitochondria in hypoxia-tolerant triplefin fish: a strategy to survive acute hypoxic exposure? Front Physiol 9:1941.LEAK
OXPHOS
ET
Other combinations
N
NS
Permeabilized tissue
Isolated mitochondria
FishesNervous system
Li 2019 Int Urol Nephrol2019Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W (2019) Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol 51:1059-70.ROUTINE
OXPHOS
ET
LEAK
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Maekawa 2019 Cell Commun Signal2019Maekawa S, Takada S, Nambu H, Furihata T, Kakutani N, Setoyama D, Ueyanagi Y, Kang D, Sabe H, Kinugawa S (2019) Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure. Cell Commun Signal 17:128.LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseHeart
Skrivergaard 2019 Viruses2019Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
HeLa
Petrick 2019 Biochem J2019Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58.OXPHOS
LEAK
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Devaux 2019 J Exp Biol2019Devaux JBL, Hickey AJR, Renshaw GMC (2019) Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/reoxygenation. J Exp Biol 222:jeb191353.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
HomogenateFishesNervous system
Jansen 2019 Am J Physiol Heart Circ Physiol2019Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseHeart
Axton 2019 J Nutr2019Axton ER, Beaver LM, St Mary L, Truong L, Logan CR, Spagnoli S, Prater MC, Keller RM, Garcia-Jaramillo M, Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM, Tanguay RL, Stevens JF, Hord NG (2019) Treatment with nitrate, but not nitrite, lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish. J Nutr 00:1–13.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaZebrafishSkeletal muscle
Greenway 2019 J Evol Biol2019Greenway EVG, Cirino LA, Wilner D, Somjee U, Anagnostou ME, Hepple RT, Miller CW (2019) Extreme variation in testes size in an insect is linked to recent mating activity. J Evol Biol 33:142-50.LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized cellsHexapodsGenital
Ruegsegger 2019 FASEB J2019Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseNervous system
Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Johansen JL, Esbaugh AJ (2019) Oil-induced responses of cardiac and red muscle mitochondria in red drum (Sciaenops ocellatus). Comp Biochem Physiol C Toxicol Pharmacol 219:35-41.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueFishesHeart
Skeletal muscle
Kappler 2019 Am J Physiol Endocrinol Metab2019Kappler L, Hoene M, Hu C, von Toerne C, Li J, Bleher D, Hoffmann C, Böhm A, Kollipara L, Zischka H, Königsrainer A, Häring HU, Peter A, Xu G, Sickmann A, Hauck SM, Weigert C, Lehmann R (2019) Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints. Am J Physiol Endocrinol Metab 317:E374-E387.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissue
Isolated mitochondria
Human
Mouse
Skeletal muscle
Liver
Gvozdjakova 2019 Bratisl Lek Listy2019Gvozdjakova A, Sumbalova Z, Kucharska J, Chladekova A, Rausova Z, Vancova O, Komlosi M, Ulicna O, Mojto V (2019) Platelet mitochondrial bioenergetic analysis in patients with nephropathies and non-communicable diseases: a new method. Bratisl Lek Listy 120:630-35.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Desmoulins 2019 Mol Metab2019Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77.OXPHOS
ET
LEAK
N
NS
HomogenateRatNervous system
Fisar 2019 Clin Biochem2019Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Sukovas 2019 J Bioenerg Biomembr2019Sukovas A, Silkuniene G, Trumbeckaite S, Jasukaitiene A, Degutyte-Fomins L, Mildaziene V, Gulbinas A, Baniene R, Dambrauskas Z, Paskauskas S (2019) Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells. J Bioenerg Biomembr 51:301-10.LEAK
OXPHOS
NPermeabilized cellsHumanGenital
Itkis 2019 Mitochondrion2019Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17.LEAK
ROUTINE
OXPHOS
ET
N
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanFibroblast
Okoye 2019 Aquat Toxicol2019Okoye CN, MacDonald-Jay N, Kamunde C (2019) Effects of bioenergetics, temperature and cadmium on liver mitochondria reactive oxygen species production and consumption. Aquat Toxicol 214:105264.LEAK
OXPHOS
NIsolated mitochondriaFishesLiver
Wolf 2019 Cells2019Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289.LEAK
ROUTINE
ET
OXPHOS
ROX
N
NS
Intact cells
Permeabilized cells
MouseFibroblast
Isei 2019 Free Radic Biol Med2019Isei MO, Kamunde C (2019) Effects of copper and temperature on heart mitochondrial hydrogen peroxide production. Free Radic Biol Med 147:114-28.N
S
ROX
Isolated mitochondriaFishesHeart
Reda 2019 Sci Rep2019Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Fang 2019 Nat Commun2019Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA (2019) NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nat Commun 10:5284.LEAK
OXPHOS
F
N
S
CIV
ROX
HomogenateMouseHeart
Nervous system
Liver
Rawat 2019 J Mol Biol2019Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015.OXPHOS
LEAK
N
S
CIV
ROX
Permeabilized cellsMouseNervous system
Other cell lines
Garcia-Roche 2019 PLoS One2019García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780.LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsBovinesLiver
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis2019Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Perry 2019 J Mol Cell Cardiol2019Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.LEAK
OXPHOS
N
S
ROX
Isolated mitochondria
Permeabilized cells
RatHeart
Ma 2019 Biochem Biophys Res Commun2019Ma T, Lin S, Wang B, Wang Q, Xia W, Zhang H, Cui Y, He C, Wu H, Sun F, Zhao Z, Gao P, Zhu Z, Liu D (2019) TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction. Biochem Biophys Res Commun 519:674-81.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseHeart
Kunz 2019 Am J Physiol Endocrinol Metab2019Kunz HE, Dasari S, Lanza IR (2019) EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver. Am J Physiol Endocrinol Metab 317:E460-E472.LEAK
OXPHOS
F
N
S
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Liver
Kim 2019 Biochim Biophys Acta Mol Basis Dis2019Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I, Minamino T, Cho KI, Park YS, Kim S, Han J (2019) Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis 1865:165524.LEAK
OXPHOS
NIsolated mitochondria
Permeabilized tissue
MouseHeart
Hunter 2019 J Appl Physiol2019Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) Relationship between V̇o2peak, cycle economy, and mitochondrial respiration in untrained/trained. J Appl Physiol 127:1562-8.LEAK
OXPHOS
F
N
Permeabilized tissueHumanSkeletal muscle
Gaviraghi 2019 Anal Biochem2019Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes. Anal Biochem 576:33-41.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueHexapodsSkeletal muscle
Repp 2019 Thesis2019Repp BM (2019) Identification and verification of novel disease-causing genes and therapy options for patients with mitochondrial disorders – Focus on ACAD9. PhD Thesis 178.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanHEK
Tarpey 2019 J Biol Chem2019Tarpey MD, Amorese AJ, Balestrieri NP, Fisher-Wellman KH, Spangenburg EE (2019) Doxorubicin causes lesions in the electron transport system of skeletal muscle mitochondria that are associated with a loss of contractile function. J Biol Chem 294:19709-22.LEAK
ET
F
N
S
CIV
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Tiebe 2019 Sci Rep2019Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Crebl2 regulates cell metabolism in muscle and liver cells. Sci Rep 9:19869.LEAK
OXPHOS
ROUTINE
F
N
Gp
ROX
Permeabilized cells
Intact cells
MouseSkeletal muscle
Liver
Rojas-Morales 2019 Free Radic Biol Med2019Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67.LEAK
OXPHOS
NIsolated mitochondriaRatKidney
Berg 2019 Front Physiol2019Berg J, Undebakke V, Rasch-Halvorsen Ø, Aakerøy L, Sandbakk Ø, Tjønna AE (2019) Comparison of mitochondrial respiration in M. triceps brachii and M. vastus lateralis between elite cross-country skiers and physically active controls. Front Physiol 10:365.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Chatfield 2019 JACC Basic Transl Sci2019Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanHeart
Dilberger 2019 Nutrients2019Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Datzmann 2019 Pharmacol Res2019Datzmann T, Hoffmann A, McCook O, Merz T, Wachter U, Preuss J, Vettorazzi S, Calzia E, Gröger M, Kohn F, Schmid A, Denoix N, Radermacher P, Wepler M (2019) Effects of sodium thiosulfate (Na2S2O3) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis. Pharmacol Res 151:104536.LEAK
OXPHOS
N
NS
HomogenatePigHeart
Liver
Kidney
Zhu 2019 Aging Cell2019Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883.LEAK
OXPHOS
ET
N
NS
S
ROX
Isolated mitochondriaMouseLiver
Oses 2019 Epilepsy Res2019Oses JP, Müller AP, Strogulski NR, Moreira JD, Böhmer AE, Hansel G, Carteri RB, Busnello JV, Kopczynski A, Rodolphi MS, Souza DO, Portela LV (2019) Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production. Epilepsy Res 152:35-41.LEAK
OXPHOS
ROUTINE
N
CIV
NS
HomogenateRatNervous system
Bahhir 2019 PLoS Genet2019Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet 15:e1008410.LEAK
OXPHOS
N
Gp
CIV
ROX
HomogenateDrosophila
Dilberger 2019 Oxid Med Cell Longev2019Dilberger B, Baumanns S, Schmitt F, Schmiedl T, Hardt M, Wenzel U, Eckert GP (2019) Mitochondrial oxidative stress impairs energy metabolism and reduces stress resistance and longevity of C. elegans. Oxid Med Cell Longev 2019:6840540.LEAK
ROUTINE
ET
N
S
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Chao 2019 J Appl Physiol (1985)2019Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) 126:1541-49.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissuePigSkeletal muscle
Zhang 2019 Redox Biol2019Zhang Y, Bharathi SS, Beck ME, Goetzman ES (2019) The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol 26:101253.LEAK
OXPHOS
N
NS
F
Isolated mitochondriaMouseLiver
Cecatto 2019 Toxicol In Vitro2019Cecatto C, Amaral AU, Roginski AC, Castilho RF, Wajner M (2019) Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. Toxicol In Vitro 62:104665.LEAK
OXPHOS
ET
N
S
Permeabilized tissue
Isolated mitochondria
RatSkeletal muscle
Langley 2019 Biochim Biophys Acta Mol Basis Dis2019Langley MR, Yoon H, Kim HN, Choi CI, Simon W, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA (2019) High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochim Biophys Acta Mol Basis Dis 1866:165630.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseNervous system
Gonzalez-Mariscal 2019 FASEB J2019González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Mejia 2019 Reprod Biol Endocrinol2019Mejia JF, Hirschi KM, Tsai KYF, Long MG, Tullis BC, Bitter EEK, Bikman BT, Reynolds PR, Arroyo JA (2019) Differential placental ceramide levels during gestational diabetes mellitus (GDM). Reprod Biol Endocrinol 17:81.LEAK
OXPHOS
ET
N
NS
Permeabilized cellsHumanGenital
Monteiro 2019 J Bioenerg Biomembr2019Monteiro J, Assis-de-Lemos G, de-Souza-Ferreira E, Marques AM, Neves GA, Silveira MS, Galina A (2019) Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. J Bioenerg Biomembr 52:1-15.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaMouseNervous system
Harhous 2019 J Mol Cell Cardiol2019Harhous Z, Badawi S, Bona NG, Pillot B, Augeul L, Paillard M, Booz GW, Canet-Soulas E, Ovize M, Kurdi M, Bidaux G (2019) Critical appraisal of STAT3 pattern in adult cardiomyocytes. J Mol Cell Cardiol 131:91-100.OXPHOS
ET
N
CIV
ROX
Isolated mitochondriaMouseHeart
Shuvo 2019 J Bioenerg Biomembr2019Shuvo SR, Wiens LM, Subramaniam S, Treberg JR, Court DA (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less Neurospora crassa mitochondria. J Bioenerg Biomembr 51:341-54.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaFungi
Wang 2019 Life Sci2019Wang JW, Xue ZY, Wu AS (2019) Mechanistic insights into δ-opioid-induced cardioprotection: Involvement of caveolin translocation to the mitochondria. Life Sci 247:116942.LEAK
OXPHOS
N
S
Isolated mitochondriaMouseHeart
Johnson 2019 Mol Metab2019Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K (2019) Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Mol Metab 31:55-66.LEAK
OXPHOS
NIsolated mitochondriaMouseFat
Lefranc 2019 Hypertension2019Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68.OXPHOS
LEAK
NIsolated mitochondriaMouseFat
Nakajima 2019 Sci Rep2019Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S (2019) Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. Sci Rep 9:3535.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanFat
Goldberg 2019 Biochem J2019Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2019) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.LEAK
ET
F
N
S
NS
Other combinations
ROX
Isolated mitochondriaMouseHeart
Kumar 2019 Free Radic Biol Med2019Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99.LEAK
ROUTINE
OXPHOS
ET
F
N
S
DQ
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Bettink 2019 Mitochondrion2019Bettink MAW, Harms FA, Dollee N, Specht PAC, Raat NJH, Schoonderwoerd GC, Mik EG (2019) Non-invasive versus ex vivo measurement of mitochondrial function in an endotoxemia model in rat: toward monitoring of mitochondrial therapy. Mitochondrion 50:149-57.LEAK
OXPHOS
ET
N
S
HomogenateRatSkeletal muscle
Richter 2019 Life Sci Alliance2019Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ (2019) Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sci Alliance 2:e201800219.OXPHOS
ET
N
CIV
NS
Permeabilized cellsHumanFibroblast
Belosludtsev 2019 Biochim Biophys Acta Biomembr2019Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2019) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta Biomembr 1861:288-97.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaRatLiver
McMurray 2019 FASEB J2019McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26.LEAK
OXPHOS
F
N
S
CIV
ROX
Permeabilized tissueMouseSkeletal muscle
Neyroud 2019 J Muscle Res Cell Motil2019Neyroud D, Nosacka RL, Judge AR, Hepple RT (2019) Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content. J Muscle Res Cell Motil 40:59-65.OXPHOSN
NS
Permeabilized cellsMouseSkeletal muscle
Dall 2019 J Biol Chem2019Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem 294:13304-26.LEAK
OXPHOS
ET
F
N
S
Intact cellsMouseLiver
Bodis 2019 J Clin Endocrinol Metab2019Bodis K, Jelenik T, Lundbom J, Markgraf DF, Strom A, Zaharia OP, Karusheva Y, Burkart V, Muessig K, Kupriyanova Y, Ouni M, Wolkersdorfer M, Hwang JH, Ziegler D, Schuermann A, Roden M, Szendroedi J (2019) Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes. J Clin Endocrinol Metab 105:dgz267.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cellsHumanFat
Wang 2019 J Biol Chem2019Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES, Prochownik EV (2019) Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts. J Biol Chem 294:5466-86.ROUTINE
OXPHOS
ET
F
N
S
NS
Permeabilized cells
Isolated mitochondria
Intact cells
RatFibroblast
Ng 2019 J Biol Chem2019Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanNeuroblastoma
Pajak 2019 PLoS Genet2019Pajak A, Laine I, Clemente P, El-Fissi N, Schober FA, Maffezzini C, Calvo-Garrido J, Wibom R, Filograna R, Dhir A, Wedell A, Freyer C, Wredenberg A (2019) Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. PLoS Genet 15:e1008240.LEAK
OXPHOS
N
S
CIV
Permeabilized tissueDrosophila
Latham 2019 J Anim Sci2019Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHorseSkeletal muscle
Vaka 2019 Am J Physiol Regul Integr Comp Physiol2019Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.LEAK
OXPHOS
ET
N
CIV
ROX
Intact cells
Isolated mitochondria
Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
Cikankova 2019 Naunyn Schmiedebergs Arch Pharmacol2019Cikánková T, Fišar Z, Bakhouche Y, Ľupták M, Hroudová J (2019) In vitro effects of antipsychotics on mitochondrial respiration. Naunyn Schmiedebergs Arch Pharmacol 392:1209-23.OXPHOSN
S
ROX
Isolated mitochondriaPigNervous system
Svab 2019 Neurochem Res2019Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L (2019) The mitochondrial targets of neuroprotective drug vinpocetine on primary neuron cultures, brain capillary endothelial cells, synaptosomes, and brain mitochondria. Neurochem Res 44:2435-47.LEAK
OXPHOS
ET
N
S
Isolated mitochondria
Intact cells
Guinea pigNervous system
Wang 2019 Metabolism2019Wang D, Liu CD, Li HF, Tian ML, Pan JQ, Shu G, Jiang QY, Yin YL, Zhang L (2019) LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue. Metabolism 102:154011.LEAKF
N
Isolated mitochondriaMouseFat
Paumelle 2019 J Hepatol2019Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.OXPHOS
LEAK
F
N
HomogenateHumanLiver
Cadiz 2019 Comp Biochem Physiol B Biochem Mol Biol2019Cadiz L, Bundgaard A, Malte H, Fago A (2019) Hypoxia enhances blood O2 affinity and depresses skeletal muscle O2 consumption in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol 234:18-25.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueZebrafishSkeletal muscle
Turnbull 2019 Am J Physiol Cell Physiol2019Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol 317:C1278-88.LEAK
OXPHOS
NPermeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Altinok 2019 J Cell Physiol2019Altinok O, Poggio JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z (2019) Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol 235:2569-81.LEAK
OXPHOS
N
S
Isolated mitochondriaHumanOther cell lines
Catalao 2019 Brain Res2019Catalão CHR, Souza AO, Santos-Júnior NN, da Silva SC, da Costa LHA, Alberici LC, Rocha MJA, da Silva Lopes L (2019) Kaolin-induced hydrocephalus causes acetylcholinesterase activity dysfunction following hypothalamic damage in infant rats. Brain Res 1724:146408.LEAK
OXPHOS
ET
N
ROX
HomogenateRatNervous system
Bianco 2019 PLoS One2019Bianco M, Lopes JA, Beiral HJV, Filho JDD, Frankenfeld SP, Fortunato RS, Gattass CR, Vieyra A, Takiya CM (2019) The contralateral kidney presents with impaired mitochondrial functions and disrupted redox homeostasis after 14 days of unilateral ureteral obstruction in mice. PLoS One 14:e0218986.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseKidney
Viana 2019 Sci Rep2019Viana LR, Tobar N, Busanello ENB, Marques AC, de Oliveira AG, Lima TI, Machado G, Castelucci BG, Ramos CD, Brunetto SQ, Silveira LR, Vercesi AE, Consonni SR, Gomes-Marcondes MCC (2019) Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats. Sci Rep 9:15529.LEAK
OXPHOS
NPermeabilized tissueRatEndothelial;epithelial;mesothelial cell
Miotto 2019 FASEB J2019Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40.LEAK
OXPHOS
N
NS
F
Permeabilized tissueHumanSkeletal muscle
Mueller 2019 Neurochem Int2019Mueller TE, Nunes MEM, Rodrigues NR, Fontana BD, Hartmann DD, Franco JL, Rosemberg DB (2019) Neurochemical mechanisms underlying acute and chronic ethanol-mediated responses in zebrafish: The role of mitochondrial bioenergetics. Neurochem Int 131:104584.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafishNervous system
Pichaud 2019 Front Genet2019Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Jaskiewicz 2019 J Clin Med2019Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694.ROUTINE
OXPHOS
ET
LEAK
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseSkeletal muscle
Other cell lines
Bouitbir 2019 Toxicology2019Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology 426:152281.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Rat
Mouse
Heart
Weinstein 2019 bioRxiv2019Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanOther cell lines
Lymphocyte
Mann 2019 Oncogene2019Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
F
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Anderson 2019 Acta Neuropathol2019Anderson CJ, Bredvik K, Burstein SR, Davis C, Meadows SM, Dash J, Case L, Milner TA, Kawamata H, Zuberi A, Piersigilli A, Lutz C, Manfredi G (2019) ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response. Acta Neuropathol 138:103-21.LEAKN
S
Isolated mitochondriaMouseHeart
Electron-transfer-pathway state2019Gnaiger E (2019) ET-pathway states. Mitochondr Physiol Network 2019-06-11 (last edit since 2016-11-08).LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
SMP
Schoepf 2019 MitoFit Preprint Arch2019Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Eichelbrönner I, Sorn P, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2019) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. MitoFit Preprint Arch doi:10.26124/mitofit:190003. - 2020-03-20 Published in »Nature Communications 11:1487«LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanGenital
Chao 2019 Am J Physiol Cell Physiol2019Chao T, Gomez BI, Heard TC, Smith BW, Dubick MA, Burmeister DM (2019) Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine. Am J Physiol Cell Physiol 317:C1229-38.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissuePigHeart
Nunes 2019 Oxid Med Cell Longev2019Nunes MEM, Schimith LE, da Costa-Silva DG, Lopes AR, Leandro LP, Martins IK, de Mello RS, Hartmann DD, de Carvalho NR, Carvalho da Rosa P, Trevisan R, Di Giulio RT, Posser T, Franco JL (2019) Acute exposure to permethrin modulates behavioral functions, redox, and bioenergetics parameters and induces DNA damage and cell death in larval zebrafish. Oxid Med Cell Longev 2019:9149203.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafish
Bajzikova 2019 Cell Metab2019Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416.OXPHOS
ET
N
S
ROX
Permeabilized cells
Homogenate
MouseEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Cardinale 2019 Front Physiol2019Cardinale DA, Larsen FJ, Lännerström J, Manselin T, Södergård O, Mijwel S, Lindholm P, Ekblom B, Boushel R (2019) Influence of hyperoxic-supplemented high-intensity interval training on hemotological and muscle mitochondrial adaptations in trained cyclists. Front Physiol 10:730.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Kolleritsch 2019 Cardiovasc Res2019Kolleritsch S, Kien B, Schoiswohl G, Diwoky C, Schreiber R, Heier C, Maresch LK, Schweiger M, Eichmann TO, Stryeck S, Krenn P, Tomin T, Kolb D, Rülicke T, Hoefler G, Wolinski H, Madl T, Birner-Gruenberger R, Haemmerle G (2019) Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice. Cardiovasc Res 116:339-52.LEAK
OXPHOS
NHomogenateMouseHeart
Shrum 2019 Biomolecules2019Shrum S, Rusch NJ, MacMillan-Crow LA (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury in vitro. Biomolecules 9:E825.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsRatKidney
Bettinazzi 2019 Proc Biol Sci2019Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
Permeabilized cellsMolluscsLung;gill
Genital
Hirschi 2019 Biol Reprod2019Hirschi KM, Tsai KYF, Davis T, Clark JC, Knowlton MN, Bikman BT, Reynolds PR, Arroyo JA (2019) Growth arrest specific protein (Gas)-6/AXL signaling induces preeclampsia (PE) in rats. Biol Reprod 102:199-210.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
RatGenital
Kirby 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Kirby AR, Cox GK, Nelson D, Heuer RM, Stieglitz JD, Benetti DD, Grosell M, Crossley DA 2nd (2019) Acute crude oil exposure alters mitochondrial function and ADP affinity in cardiac muscle fibers of young adult Mahi-mahi (Coryphaena hippurus). Comp Biochem Physiol C Toxicol Pharmacol 218:88-95.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueFishesHeart
Munro 2019 Aging Cell2019Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaMouse
Other mammals
Heart
Skeletal muscle
Nold 2019 Psychoneuroendocrinology2019Nold V, Sweatman C, Karabatsiakis A, Böck C, Bretschneider T, Lawless N, Fundel-Clemens K, Kolassa IT, Allers KA (2019) Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress. Psychoneuroendocrinology 107:148-59.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Gururaja Rao 2019 Cells2019Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaDrosophila
Dechandt 2019 Front Neurol2019Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissueRatNervous system
Doig 2019 bioRxiv2019Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Halbach 2019 Am J Physiol Regul Integr Comp Physiol2019Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A (2019) Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. Am J Physiol Regul Integr Comp Physiol 317:R160-R168.LEAK
OXPHOS
N
NS
Intact cellsMouseLiver
De Moura Escobar 2019 Toxicol In Vitro2019de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro 61:104640.LEAK
OXPHOS
N
S
ROX
Permeabilized cellsHumanNeuroblastoma
Glombik 2019 Neurotox Res2019Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaRatNervous system
Hughes 2019 J Physiol2019Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR (2019) Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy. J Physiol 598:1377-92.OXPHOS
LEAK
N
NS
Permeabilized tissueMouseHeart
Garrido-Maraver 2019 Cell Death Dis2019Garrido-Maraver J, Celardo I, Costa AC, Lehmann S, Loh SHY, Martins LM (2019) Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin. Cell Death Dis 10:288.OXPHOS
ET
N
S
Permeabilized tissueDrosophila
Park 2019 Behav Brain Res2019Park SS, Park HS, Kim CJ, Baek SS, Kim TW (2019) Exercise attenuates maternal separation-induced mood disorder-like behaviors by enhancing mitochondrial functions and neuroplasticity in the dorsal raphe. Behav Brain Res 372:112049.LEAK
OXPHOS
N
NS
RatNervous system
Brunetta 2019 J Funct Foods2019Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Svensson 2019 Am J Physiol Endocrinol Metab2019Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S (2019) Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab 318:E145-51.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Fisher-Wellman 2019 Cell Rep2019Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.LEAK
OXPHOS
ET
F
N
S
Gp
Isolated mitochondriaMouseHeart
Skeletal muscle
Aubin 2019 Thesis2019Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99.ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanLymphocyte
Rudler 2019 Sci Adv2019Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A (2019) Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv 5:eaay2118.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Friederich 2019 Mol Genet Metab2019Friederich MW, Perez FA, Knight KM, Van Hove RA, Yang SP, Saneto RP, Van Hove JLK (2019) Pathogenic variants in NUBPL result in failure to assemble the matrix arm of complex I and cause a complex leukoencephalopathy with thalamic involvement. Mol Genet Metab 129:236-42.OXPHOS
ET
N
S
CIV
NS
HumanFibroblast
Gaglianone 2019 Sci Rep2019Gaglianone RB, Santos AT, Bloise FF, Ortiga-Carvalho TM, Costa ML, Quirico-Santos T, da Silva WS, Mermelstein C (2019) Reduced mitochondrial respiration and increased calcium deposits in the EDL muscle, but not in soleus, from 12-week-old dystrophic mdx mice. Sci Rep 9:1986.LEAK
OXPHOS
ET
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
De-Souza-Ferreira 2019 J Neurochem2019de-Souza-Ferreira E, Rios-Neto IM, Martins EL, Galina A (2019) Mitochondria-coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain. J Neurochem 149:624-40.LEAK
OXPHOS
ET
N
Gp
CIV
NS
Isolated mitochondriaRatNervous system
Rodinova 2019 Dis Model Mech2019Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.LEAK
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaPigSkeletal muscle
Tomasic 2019 Biochim Biophys Acta Mol Basis Dis2019Tomašić N, Kotarsky H, de Oliveira Figueiredo R, Hansson E, Mörgelin M, Tomašić I, Kallijärvi J, Elmér E, Jauhiainen M, Eklund EA, Fellman V (2019) Fasting reveals largely intact systemic lipid mobilization mechanisms in respiratory chain complex III deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165573.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouseLiver
Flis 2019 Int J Mol Sci2019Flis DJ, Dzik K, Kaczor JJ, Cieminski K, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2019) Swim training modulates mouse skeletal muscle energy metabolism and ameliorates reduction in grip strength in a mouse model of amyotrophic lateral sclerosis. Int J Mol Sci 20:E233.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Krischek 2019 Meat Sci2019Krischek C, Popp J, Sharifi AR (2019) Biochemical alterations in the Musculus triceps brachii and Musculus longissimus thoracis during early postmortem period in pigs. Meat Sci 152:121-26.OXPHOSNPermeabilized tissuePigSkeletal muscle
Gonzalez-Armenta 2019 J Nutr2019Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized tissueOther mammalsSkeletal muscle
Sambeat 2019 Nat Commun2019Sambeat A, Ratajczak J, Joffraud M, Sanchez-Garcia JL, Giner MP, Valsesia A, Giroud-Gerbetant J, Valera-Alberni M, Cercillieux A, Boutant M, Kulkarni SS, Moco S, Canto C (2019) Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage. Nat Commun 10:4291.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Ferreira 2019 EMBO J2019Ferreira N, Perks KL, Rossetti G, Rudler DL, Hughes LA, Ermer JA, Scott LH, Kuznetsova I, Richman TR, Narayana VK, Abudulai LN, Shearwood AJ, Cserne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O (2019) Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation. EMBO J 38:e102155.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Liver
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol2019Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21.OXPHOS
ET
LEAK
N
S
Gp
CIV
NS
ROX
Permeabilized tissueOther invertebratesSkeletal muscle
Driescher 2019 Heliyon2019Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357.LEAK
OXPHOS
ET
F
N
CIV
ROX
Permeabilized tissueRatHeart
Silva Ramos 2019 PLoS Genet2019Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085.LEAK
OXPHOS
ET
N
S
Gp
Permeabilized cells
Isolated mitochondria
MouseHeart
Fibroblast
Pino 2019 Physiol Genomics2019Pino MF, Stephens NA, Eroshkin AM, Yi F, Hodges A, Cornnell HH, Pratley RE, Smith SR, Wang M, Han X, Coen PM, Goodpaster BH, Sparks LM (2019) Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with type 2 diabetes. Physiol Genomics 51:586-95.LEAK
OXPHOS
ET
N
NS
Permeabilized cells
Permeabilized tissue
HumanSkeletal muscle
Courtes 2019 Biomed Pharmacother2019Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46.OXPHOS
LEAK
N
S
NS
ROX
Isolated mitochondriaRatLiver
Seo 2019 Exp Neurol2019Seo JH, Park HS, Park SS, Kim CJ, Kim DH, Kim TW (2019) Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Exp Neurol 322:113043.LEAK
OXPHOS
N
NS
Isolated mitochondriaRatNervous system
Baekkerud 2019 Cardiovasc Toxicol2019Bækkerud FH, Salerno S, Ceriotti P, Morland C, Storm-Mathisen J, Bergersen LH, Høydal MA, Catalucci D, Stølen TO (2019) High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovasc Toxicol 19:422-31.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseHeart
Kopinski 2019 Proc Natl Acad Sci U S A2019Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Sabogal-Guaqueta 2019 Biomed Pharmacother2019Sabogal-Guáqueta AM, Hobbie F, Keerthi A, Oun A, Kortholt A, Boddeke E, Dolga A (2019) Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomed Pharmacother 118:109295.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseNervous system
Ahn 2019 J Cachexia Sarcopenia Muscle2019Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28.OXPHOS
LEAK
N
S
CIV
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Sundstroem 2019 Acta Neuropathol Commun2019Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55.ET
LEAK
N
S
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Scavuzzo 2019 J Neurophysiol2019Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35.LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatNervous system
Cecatto 2019 Mitochondrion2019Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2019) Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. Mitochondrion 50:1-13.LEAK
OXPHOS
ET
N
S
Permeabilized cells
Isolated mitochondria
RatLiver
Other cell lines
Cesnekova 2019 Thesis2019Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133.OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanHEK
Detaille 2019 PLoS One2019Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaRatHeart
Garnham 2019 J Cachexia Sarcopenia Muscle2019Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle 11:79-88.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Christian 2019 Respir Physiol Neurobiol2019Christian AR, Losantos-Ramos K, Marcelino G, Daniela F, Jorge S (2019) NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent. Respir Physiol Neurobiol 266:156-62.LEAK
OXPHOS
NPermeabilized tissueMouseNervous system
Oakey 2019 Wellcome Open Res2019Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG (2019) Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion. Wellcome Open Res 3:147.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Qaed 2019 Oxid Med Cell Longev2019Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxid Med Cell Longev 2019:6521218.LEAK
OXPHOS
ET
ROUTINE
N
S
NS
ROX
Homogenate
Isolated mitochondria
Permeabilized cells
Intact cells
RatHeart
Poudel 2019 Can J Physiol Pharmacol2019Poudel A, Zhou JY, Mekala N, Welchko R, Rosca MG, Li L (2019) Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol 97:699-707.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
McManus 2019 Cell Metab2019McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90.LEAK
OXPHOS
N
ROX
Isolated mitochondriaMouseHeart
Halling 2019 Am J Physiol Endocrinol Metab2019Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Grandoch 2019 Nat Metab2019Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M5, Haendeler J, Fischer JW (2019) 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1:546-59.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseFat
Havird 2019 Philos Trans R Soc Lond B Biol Sci2019Havird JC, Shah AA, Chicco AJ (2019) Powerhouses in the cold: mitochondrial function during thermal acclimation in montane mayflies. Philos Trans R Soc Lond B Biol Sci 375:20190181.LEAK
OXPHOS
N
NS
Isolated mitochondriaHexapods
Andreazza 2019 Nat Commun2019Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, Whitworth AJ (2019) Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila. Nat Commun 10:3280.OXPHOSN
S
HomogenateDrosophila
Mayeuf-Louchart 2019 Cell Rep2019Mayeuf-Louchart A, Lancel S, Sebti Y, Pourcet B, Loyens A, Delhaye S, Duhem C, Beauchamp J, Ferri L, Thorel Q, Boulinguiez A, Zecchin M, Dubois-Chevalier J, Eeckhoute J, Vaughn LT, Roach PJ, Dani C, Pederson BA, Vincent SD, Staels B, Duez H (2019) Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation. Cell Rep 29:1410-18.LEAK
OXPHOS
F
N
S
NS
Permeabilized cellsMouseFat
Zhang 2019 Nephron2019Zhang R, Wang X, Gao Q, Jiang H, Zhang S, Lu M, Liu F, Xue X (2019) Taurine supplementation reverses diabetes-induced podocytes injury via modulation of the CSE/TRPC6 axis and improvement of mitochondrial function. Nephron 144:84-95.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
MouseKidney
Douros 2019 JCI Insight2019Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688.LEAK
OXPHOS
ET
N
Gp
NS
Permeabilized tissueMouseIslet cell;pancreas;thymus
Halle 2019 Am J Physiol Regul Integr Comp Physiol2019Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Liver
Fat
Zhang 2019 Biochem Biophys Res Commun2019Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseLiver
Pharaoh 2019 Mol Neurobiol2019Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
Intact cells
MouseSkeletal muscle
Nervous system
Fat
Rajendran 2019 EMBO Mol Med2019Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaMouseLiver
Kidney
Heart
Krylova 2019 Mitochondrion2019Krylova TD, Sheremet NL, Tabakov VY, Lyamzaev KG, Itkis YS, Tsygankova PG, Andreeva NA, Shmelkova MS, Nevinitsyna TA, Kadyshev VV, Zakharova EY (2019) Three rare pathogenic mtDNA substitutions in LHON patients with low heteroplasmy. Mitochondrion 50:139-144.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Carteri 2019 Toxicol Lett2019Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseNervous system
Fiorenza 2019 FASEB J2019Fiorenza M, Lemminger AK, Marker M, Eibye K, Iaia FM, Bangsbo J, Hostrup M (2019) High-intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature-dependent manner in human skeletal muscle: implications for exercise performance. FASEB J 33:8976-89.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Boardman 2019 Can J Physiol Pharmacol2019Boardman NT, Falck AT, Lund T, Chu X, Martin-Armas M, Norvik JV, Jenssen TG, Ytrehus K (2019) Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress. Can J Physiol Pharmacol 98:139-46.LEAK
OXPHOS
NIsolated mitochondriaRatHeart
Shao 2019 Cardiovasc Diabetol2019Shao Q, Meng L, Lee S, Tse G, Gong M, Zhang Z, Zhao J, Zhao Y, Li G, Liu T (2019) Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induce diabetic rats. Cardiovasc Diabetol 18:165.LEAK
OXPHOS
NIsolated mitochondriaRatHeart
Madlala 2019 Integr Food Nutr Metab2019Madlala HP, Maarman GJ, Ojuka E (2019) Fructose impairs mitochondrial respiration and substrate utilization in hepatocytes via the enzyme, glutamate oxaloacetate transaminase. Integr Food Nutr Metab doi: 10.15761/IFNM.1000228.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized cellsHumanLiver
Miranda Mendonca 2019 Neurochem Int2019Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized tissueMouseNervous system
Havird 2019 Mitochondrion2019Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11.LEAK
OXPHOS
N
S
CIV
NS
ROX
Isolated mitochondriaPlants
Miranda-Silva 2019 Acta Physiologica2019Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact organ
Permeabilized tissue
Isolated mitochondria
RatHeart
Gratl 2019 Eur J Vasc Endovasc Surg2019Gratl A, Frese J, Speichinger F, Pesta D, Frech A, Omran S, Greiner A (2019) Regeneration of mitochondrial function in gastrocnemius muscle in peripheral arterial disease after successful revascularisation. Eur J Vasc Endovasc Surg 59:109-15.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Monteiro 2019 Thesis2019Monteiro ARB (2019) Effects of resistance training on mitochondrial function and gene expression of UCP-3 in muscles of ovariectomized rats. Dissertation 82.LEAK
OXPHOS
ET
NPermeabilized tissueRatSkeletal muscle
Naszai 2019 Sci Rep2019Nászai A, Terhes E, Kaszaki J, Boros M, Juhász L (2019) Ca(2+)N it be measured? Detection of extramitochondrial calcium movement with high-resolution FluoRespirometry. Sci Rep 9:19229.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaRatLiver
Huerta 2019 Aquat Toxicol2019Huerta B, Chung-Davidson YW, Bussy U, Zhang Y, Bazil JN, Li W (2019) Sea lamprey cardiac mitochondrial bioenergetics after exposure to TFM and its metabolites. Aquat Toxicol 219:105380.LEAK
OXPHOS
ET
N
S
ROX
Isolated mitochondriaFishesHeart
Zhao 2019 Basic Res Cardiol2019Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
RatHeart
Fibroblast
Pedrotti 2019 Sci Adv2019Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cellsMouseFat
Ling 2019 Am J Clin Nutr2019Ling Y, Carayol J, Galusca B, Canto C, Montaurier C, Matone A, Vassallo I, Minehira K, Alexandre V, Cominetti O, Núñez Galindo A, Corthésy J, Dayon L, Charpagne A, Métairon S, Raymond F, Descombes P, Casteillo F, Peoc'h M, Palaghiu R, Féasson L, Boirie Y, Estour B, Hager J, Germain N, Gheldof N (2019) Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue. Am J Clin Nutr 110:605-16.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Fat
Kumari 2019 Am J Physiol Heart Circ Physiol2019Kumari S, Braun RK, Tetri L, Barton GP, Hacker TA, Goss KN (2019) Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart. Am J Physiol Heart Circ Physiol 317:H1272-81.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized tissueRatHeart
Hamraz 2019 FASEB J2019Hamraz M, Abolhassani R, Andriamihaja M, Ransy C, Lenoir V, Schwartz L, Bouillaud F (2019) Hypertonic external medium represses cellular respiration and promotes Warburg/Crabtree effect. FASEB J 34:222-36.LEAK
ET
OXPHOS
ROX
N
CIV
Isolated mitochondria
Intact cells
Other mammals
Human
Rat
Endothelial;epithelial;mesothelial cell
Liver
HEK
Neuroblastoma
Haberman 2019 Nat Commun2019Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I, Braun T, Novak E, Bauman L, Collins MH, Mo A, Rosen MJ, Bonkowski E, Gotman N, Marquis A, Nistel M, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, Leleiko NS, Heyman MB, Grifiths AM, Patel AS, Noe JD, Aronow BJ, Kugathasan S, Walters TD, Gibson G, Thomas SD, Mollen K, Shen-Orr S, Huttenhower C, Xavier RJ, Hyams JS, Denson LA (2019) Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun 10:38.OXPHOS
ET
N
S
NS
HomogenateHumanEndothelial;epithelial;mesothelial cell
Manfredini 2019 Clin Sci (Lond)2019Manfredini A, Constantino L, Pinto MC, Michels M, Burger H, Kist LW, Silva MC, Gomes LM, Dominguini D, Steckert A, Simioni C, Bogo M, Streck E, Barichello T, de Quevedo J, Singer M, Ritter C, Dal-Pizzol F (2019) Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model. Clin Sci (Lond) 133:1993-2004.LEAK
OXPHOS
N
NS
Permeabilized tissueRatNervous system
Robinson 2019 Am J Physiol Cell Physiol2019Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.LEAK
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cellsMouse
Rat
Skeletal muscle
Dent 2019 J Appl Physiol (1985)2019Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) 127:1117-27.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Ferey 2019 Am J Physiol Heart Circ Physiol2019Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH (2019) Maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol 316:H1202-H1210.LEAK
OXPHOS
N
S
NS
Permeabilized tissueMouseHeart
Liu 2019 J Ethnopharmacol2019Liu M, Yu S, Wang J, Qiao J, Liu Y, Wang S, Zhao Y (2019) Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson's disease. J Ethnopharmacol 247:112213.OXPHOSN
S
HomogenateDrosophila
Woodman 2019 Cardiovasc Res2019Woodman AG, Mah R, Keddie DL, Noble RMN, Holody CD, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2019) Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress. Cardiovasc Res 116:183-92.LEAK
OXPHOS
ET
N
S
CIV
NS
HomogenateRatKidney
Lewis 2019 Am J Physiol Regul Integr Comp Physiol2019Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes. Am J Physiol Regul Integr Comp Physiol 317:R356-68.LEAK
OXPHOS
F
N
Isolated mitochondriaRatSkeletal muscle
Kwak 2019 Int J Environ Res Public Health2019Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN (2019) Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. Int J Environ Res Public Health 16:E1157.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cellsHumanSkeletal muscle
Rose 2019 Am J Physiol Endocrinol Metab2019Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Intact cells
HumanSkeletal muscle
Blood cells
Platelet
Karusheva 2019 Am J Clin Nutr2019Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M (2019) Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr 110:1098-107.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Magga 2019 Mol Ther2019Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R (2019) Systemic blockade of ACVR2B ligands protects myocardium from acute ischemia-reperfusion injury. Mol Ther 27:600-10.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Koop 2019 Int J Cardiol2019Koop AMC, Hagdorn QAJ, Bossers GPL, van Leusden T, Gerding A, van Weeghel M, Vaz FM, Koonen DPY, Silljé HHW, Berger RMF, Bartelds B (2019) Right ventricular pressure overload alters cardiac lipid composition. Int J Cardiol 287:96-105.OXPHOSF
N
Isolated mitochondriaRatHeart
Germain 2019 Int J Med Sci2019Germain N, Dessein AF, Vienne JC, Dobbelaere D, Mention K, Joncquel M, Dekiouk S, Laine W, Kluza J, Marchetti P (2019) First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: A preliminary study. Int J Med Sci 16:931-38.LEAK
ET
ROX
N
Intact cellsHumanFibroblast
Diao 2019 Brain Res2019Diao X, Zhou Z, Xiang W, Jiang Y, Tian N, Tang X, Chen S, Wen J, Chen M, Liu K, Li Q, Liao R (2019) Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction. Brain Res 1727:146514.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseNervous system
Chiba 2019 J Am Soc Nephrol2019Chiba T, Peasley KD, Cargill KR, Maringer KV, Bharathi SS, Mukherjee E, Zhang Y, Holtz A, Basisty N, Yagobian SD, Schilling B, Goetzman ES, Sims-Lucas S (2019) Sirtuin 5 regulates proximal tubule fatty acid oxidation to protect against AKI. J Am Soc Nephrol 30:2384-98.OXPHOSN
S
HomogenateMouseKidney
Stepanova 2019 Antioxid Redox Signal2019Stepanova Anna, Sosunov S, Niatsetskaya Z, Konrad Csaba, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin Alexander (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22.LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseNervous system
Jaiswal 2019 Mol Metab2019Jaiswal N, Gavin MG, Quinn WJ 3rd, Luongo TS, Gelfer RG, Baur JA, Titchenell PM (2019) The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Mol Metab 28:1-13.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Deutschman 2019 J Cell Sci2019Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
McBride 2019 Arch Biochem Biophys2019McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.LEAK
OXPHOS
F
N
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol2019Rodríguez-Enríquez S, Pacheco-Velázquez SC, Marín-Hernández Á, Gallardo-Pérez JC, Robledo-Cadena DX, Hernández-Reséndiz I, García-García JD, Belmont-Díaz J, López-Marure R, Hernández-Esquivel L, Sánchez-Thomas R, Moreno-Sánchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77.LEAK
OXPHOS
N
S
Isolated mitochondriaRatHeart
Liver
Long 2019 Methods Mol Biol2019Long Q, Huang L, Huang K, Yang Q (2019) Assessing mitochondrial bioenergetics in isolated mitochondria from mouse heart tissues using Oroboros Oxygraph-2k. Methods Mol Biol 1966:237-46.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseHeart
Shirakawa 2019 Sci Rep2019Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T (2019) Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Sci Rep 9:14709.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsHumanBlood cells
Thome 2019 Am J Physiol Cell Physiol2019Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13.LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Isolated mitochondria
Intact cells
MouseSkeletal muscle
Ramos 2019 Am J Physiol Cell Physiol2019Ramos SV, Hughes MC, Perry CGR (2019) Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies. Am J Physiol Cell Physiol 316:C449-C455.OXPHOSNPermeabilized tissueRatSkeletal muscle
Zhou 2019 Int J Mol Sci2019Zhou X, Luethi D, Sanvee GM, Bouitbir J, Liechti ME, Krähenbühl S (2019) Molecular toxicological mechanisms of synthetic cathinones on C2C12 myoblasts. Int J Mol Sci 20:E1561.OXPHOSNPermeabilized cellsMouseSkeletal muscle
Dlaskova 2019 Biochim Biophys Acta Bioenerg2019Dlasková A, Špaček T, Engstová H, Špačková J, Schröfel A, Holendová B, Smolková K, Plecitá-Hlavatá L, Ježek P (2019) Mitochondrial cristae narrowing upon higher 2-oxoglutarate load. Biochim Biophys Acta Bioenerg 1860:659-78.LEAK
ET
N
ROX
Intact cellsHumanLiver
Jiang 2019 EMBO Rep2019Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG (2019) TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep 20:e48101.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Heden 2019 Sci Adv2019Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019) Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv 5:eaax8352.LEAK
OXPHOS
F
N
S
DQ
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Fink 2019 FASEB J2019Fink BD, Yu L, Sivitz WI (2019) Modulation of complex II-energized respiration in muscle, heart, and brown adipose mitochondria by oxaloacetate and complex I electron flow. FASEB J 33:11696-705.OXPHOSN
S
Isolated mitochondriaMouseHeart
Skeletal muscle
Fat
Aguilar 2019 Cell Rep2019Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, Guilmeau S, Alves-Guerra MC (2019) UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep 28:2306-16.LEAK
OXPHOS
NHomogenateMouseEndothelial;epithelial;mesothelial cell
Datzmann 2019 J Neurosurg2019Datzmann T, Kapapa T, Scheuerle A, McCook O, Merz T, Unmuth S, Hoffmann A, Mathieu R, Mayer S, Mauer UM, Roehrer S, Yilmazer-Hanke D, Moeller P, Nussbaum BL, Calzia E, Groeger M, Hartmann C, Radermacher P, Wepler M (2019) In-depth characterization of a long-term, resuscitated model of acute subdural hematoma-induced brain injury. J Neurosurg [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
HomogenatePigNervous system
Calabria 2019 Front Neurosci2019Calabria Elisa, Scambi Ilaria, Bonafede Roberta, Schiaffino Lorenzo, Peroni Daniele, Potrich Valentina, Capelli Carlo, Schena Federico, Mariotti Raffaella (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an in vitro model of ALS. Front Neurosci 13:1070.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseNervous system
Hafen 2019 J Appl Physiol (1985)2019Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Dannheisig 2019 Cells2019Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019) Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux. Cells 8:E894.LEAK
ROUTINE
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Nambu 2019 Eur J Pharmacol2019Nambu H, Takada S, Fukushima A, Matsumoto J, Kakutani N, Maekawa S, Shirakawa R, Nakano I, Furihata T, Katayama T, Yamanashi K, Obata Y, Saito A, Yokota T, Kinugawa S (2019) Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure. Eur J Pharmacol 866:172810.LEAK
OXPHOS
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Oliveira 2019 Mol Nutr Food Res2019Oliveira TE, Castro É, Belchior T, Andrade ML, Chaves-Filho AB, Peixoto AS, Moreno MF, Ortiz Silva M, Moreira RJ, Inague A, Yoshinaga MY, Miyamoto S, Moustaid-Moussa N, Festuccia WT (2019) Fish oil protects wild type and uncoupling protein 1 deficient mice from obesity and glucose intolerance by increasing energy expenditure. Mol Nutr Food Res 63:e1800813.ET
LEAK
NIsolated mitochondriaMouseFat
Ahmed 2019 Mol Nutr Food Res2019Ahmed N, Tcheng M, Roma A, Buraczynski M, Jayanth P, Rea K, Akhtar TA, Spagnuolo PA (2019) Avocatin B protects against lipotoxicity and improves insulin sensitivity in diet-induced obesity. Mol Nutr Food Res 63:e1900688.LEAK
ROUTINE
ET
N
ROX
Intact cellsMouse
Rat
Skeletal muscle
Islet cell;pancreas;thymus
Wiberg 2019 Eur Heart J Acute Cardiovasc Care2019Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care [Epub ahead of print].OXPHOS
ET
LEAK
N
NS
Permeabilized tissueHumanSkeletal muscle
Chroeis 2019 Eur J Sport Sci2019Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci 20:135-45.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
Chabi 2019 MitoFit Preprint Arch EA2019Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MitoEAGLE.0001.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Esselun 2019 Oxid Med Cell Longev2019Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP (2019) Differential effects of silibinin A on mitochondrial function in neuronal PC12 and HepG2 liver cells. Oxid Med Cell Longev 2019:1652609.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized cellsHuman
Rat
Nervous system
Liver
Chang 2019 Br J Anaesth2019Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HumanSkeletal muscle
Powers 2019 Neurourol Urodyn2019Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL (2019) Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. Neurourol Urodyn 38:1524-32.LEAK
OXPHOS
N
S
CIV
NS
HomogenateMouseOther cell lines
Martines 2019 Sci Rep2019Martines AMF, Gerding A, Stolle S, Vieira-Lara MA, Wolters JC, Jurdzinski A, Bongiovanni L, de Bruin A, van der Vlies P, van der Vries G, Bloks VW, Derks TGJ, Reijngoud DJ, Bakker BM (2019) Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Sci Rep 9:14539.LEAK
OXPHOS
F
N
Isolated mitochondriaMouseLiver
Pignanelli 2019 Am J Physiol Regul Integr Comp Physiol2019Pignanelli C, Petrick HL, Keyvani F, Heigenhauser GJF, Quadrilatero J, Holloway GP, Burr JF (2019) Low-load resistance training to task-failure with and without blood flow restriction: muscular functional and structural adaptations. Am J Physiol Regul Integr Comp Physiol 318:R284-95.OXPHOS
LEAK
N
NS
Permeabilized tissueHumanSkeletal muscle
Salin 2019 Proc Biol Sci2019Salin K, Villasevil EM, Anderson GJ, Lamarre SG, Melanson CA, McCarthy I, Selman C, Metcalfe NB (2019) Differences in mitochondrial efficiency explain individual variation in growth performance. Proc Biol Sci 286:20191466.OXPHOSN
CIV
NS
HomogenateFishesSkeletal muscle
Liver
Gnaiger 2019 MitoFit Preprint Arch2019Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6.LEAK
OXPHOS
ET
F
N
S
Gp
DQ
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Power 2019 PLoS One2019Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML (2019) Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment. PLoS One 14:e0214740.LEAK
OXPHOS
N
NS
Permeabilized tissueRatHeart
Berru 2019 Sci Rep2019Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE (2019) Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics. Sci Rep 9:15547.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Bittel 2019 Diabetologia2019Bittel AJ, Bittel DC, Mittendorfer B, Patterson BW, Okunade AL, Yoshino J, Porter LC, Abumrad NA, Reeds DN, Cade WT (2019) A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes. Diabetologia 63:611-23.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Scheiber 2019 Exp Mol Med2019Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J (2019) High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med 51:16.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissue
Isolated mitochondria
HumanHeart
Bettinazzi 2019 Cryobiology2019Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
S
Other combinations
Permeabilized tissueMolluscsLung;gill
Dollerup 2019 J Physiol2019Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kluckova 2019 FASEB J2019Kluckova K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA (2019) Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function. FASEB J 34:303-315.LEAK
ROUTINE
OXPHOS
ET
F
N
NS
ROX
Permeabilized cells
Intact cells
MouseNervous system
Thomas 2019 Redox Biol2019Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155.LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsRatLiver
Holsgrove 2019 Thesis2019Holsgrove A (2019) The effect of temperature on cardiac energetics in the rainbow trout, Onchorhynchus mykiss. Phd Thesis 166.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateFishesHeart
Lemieux 2019 bioRxiv2019Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
MouseBlood cells
Esteves 2019 Oncogene2019Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene 39:617-36.LEAK
ROUTINE
OXPHOS
ET
N
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Penniman 2019 Mol Metab2019Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT (2019) Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity. Mol Metab 30:203-220.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Tyrrell 2019 Circ Res2019Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314.OXPHOS
ET
N
S
NS
ROX
MouseEndothelial;epithelial;mesothelial cell
Larsen 2019 Appl Physiol Nutr Metab2019Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab 44:958-64.OXPHOS
ET
LEAK
N
NS
Permeabilized tissueHumanSkeletal muscle
Fernando 2019 Exp Gerontol2019Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Petrick 2019 J Physiol2019Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. J Physiol 597:3985-97.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Ederle 2019 J Clin Med2019Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanBlood cells
Gregg 2019 J Biol Chem2019Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66.OXPHOS
ET
LEAK
N
S
NS
ROX
Permeabilized tissueMouseIslet cell;pancreas;thymus
Azevedo 2019 Food Chem Toxicol2019Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol 132:110694.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissueRatLiver
Spinazzi 2019 Proc Natl Acad Sci U S A2019Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Mazaki 2019 Biochem Biophys Res Commun2019Mazaki Y, Takada S, Nio-Kobayashi J, Maekawa S, Higashi T, Onodera Y, Sabe H (2019) Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells. Biochem Biophys Res Commun 513:708-13.OXPHOSN
S
Permeabilized cellsHumanBlood cells
Majiene 2019 Nutrients2019Majiene D, Kuseliauskyte J, Stimbirys A, Jekabsone A (2019) Comparison of the effect of native 1,4-naphthoquinones plumbagin, menadione, and lawsone on viability, redox status, and mitochondrial functions of C6 glioblastoma cells. Nutrients 11:E1294.LEAK
OXPHOS
ET
N
NS
Permeabilized cellsRatNervous system
Macedo 2019 Biochim Biophys Acta Mol Cell Biol Lipids2019Macedo F, Martins GL, Luévano-Martínez LA, Viana GM, Riske KA, Inague A, Yoshinaga MY, Aguilaniu H, Miyamoto S, Glezer I, da Cunha FM (2019) Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158539.LEAK
OXPHOS
N
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Teh 2019 Mol Cancer Ther2019Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.LEAK
ROUTINE
OXPHOS
ET
N
S
DQ
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Human
Mouse
Other cell lines
Crescenzo 2019 Mol Neurobiol2019Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Papadimitriou 2019 Sci Rep2019Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Lau 2019 Comp Biochem Physiol B Biochem Mol Biol2019Lau GY, Milsom WK, Richards JG, Pamenter ME (2019) Heart mitochondria from naked mole-rats (Heterocephalus glaber) are more coupled, but similarly susceptible to anoxia-reoxygenation stress than in laboratory mice (Mus musculus). Comp Biochem Physiol B Biochem Mol Biol 240:110375.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouse
Other mammals
Heart
Inigo 2019 Mol Metab2019Inigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg EE (2019) Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab 34:1-15.LEAK
OXPHOS
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Malyala 2019 PLoS Comput Biol2019Malyala S, Zhang Y, Strubbe JO, Bazil JN (2019) Calcium phosphate precipitation inhibits mitochondrial energy metabolism. PLoS Comput Biol 15:e1006719.OXPHOS
LEAK
N
S
Isolated mitochondriaGuinea pigHeart
Cormier 2019 Sci Rep2019Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531.LEAK
OXPHOS
ET
N
Gp
NS
ROX
CIV
Permeabilized tissueDrosophilaSkeletal muscle
Paradis 2019 Antioxidants (Basel)2019Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168.LEAK
OXPHOS
N
S
CIV
Permeabilized tissueMouseSkeletal muscle
Hunter 2019 J Appl Physiol (1985)2019Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) Relationship between VO2max, cycle economy & mitochondrial respiration in untrained/trained. J Appl Physiol (1985) 127:1562-68.LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Rutai 2019 Shock2019Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95.LEAK
OXPHOS
N
S
ROX
HomogenateRatLiver
Teulier 2019 Comp Biochem Physiol A Mol Integr Physiol2019Teulier L, Thoral E, Queiros Q, McKenzie DJ, Roussel D, Dutto G, Gasset E, Bourjea J, Saraux C (2019) Muscle bioenergetics of two emblematic Mediterranean fish species: Sardina pilchardus and Sparus aurata. Comp Biochem Physiol A Mol Integr Physiol 235:174-79.LEAK
OXPHOS
ET
F
N
NS
ROX
Intact cellsFishesSkeletal muscle
Cornacchia 2019 Cell Stem Cell2019Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L (2019) Lipid deprivation induces a stable, naive-to-primed intermediate state of pluripotency in human PSCs. Cell Stem Cell 25:120-36.LEAK
ET
N
CIV
Intact cellsHumanStem cells
Hsu 2019 J Clin Med2019Hsu CC, Tsai HH, Fu TC, Wang JS (2019) Exercise training enhances platelet mitochondrial bioenergetics in stroke patients: a randomized controlled trial. J Clin Med 8:E2186.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized cellsHumanPlatelet
Blood cells
Tetsi 2019 Antioxidants (Basel)2019Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B (2019) Effect of the phosphodiesterase 5 inhibitor sildenafil on ischemia-reperfusion-induced muscle mitochondrial dysfunction and oxidative stress. Antioxidants (Basel) 8:E93.LEAK
OXPHOS
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Mazzoli 2019 Nutrients2019Mazzoli A, Crescenzo R, Cigliano L, Spagnuolo MS, Cancelliere R, Gatto C, Iossa S (2019) Early hepatic oxidative stress and mitochondrial changes following western diet in middle aged rats. Nutrients 11:E2670.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatLiver
Maekawa 2019 Biochem Biophys Rep2019Maekawa S, Takada S, Furihata T, Fukushima A, Yokota T, Kinugawa S (2019) Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle. Biochem Biophys Rep 21:100717.OXPHOSN
S
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Anton 2019 Front Physiol2019Anton L, DeVine A, Polyak E, Olarerin-George A, Brown AG, Falk MJ, Elovitz MA (2019) HIF-1α stabilization increases miR-210 eliciting first trimester extravillous trophoblast mitochondrial dysfunction. Front Physiol 10:699.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanGenital
McCoin 2019 Am J Physiol Endocrinol Metab2019McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab 317:E298-E311.LEAK
OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
Grauso 2019 Sci Rep2019Grauso M, Lan A, Andriamihaja M, Bouillaud F, Blachier F (2019) Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro. Sci Rep 9:11360.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Chroeis 2019 Basic Clin Pharmacol Toxicol2019Chroeis KM, Larsen S, Pedersen JS, Rygg MO, Boilsen AEB, Bendtsen F, Dela F (2019) Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue. Basic Clin Pharmacol Toxicol [Epub ahead of print].LEAK
OXPHOS
N
S
ROX
Intact cellsHumanLiver
Szibor 2019 Biochim Biophys Acta Bioenerg2019Szibor Marten, Gainutdinov Timur, Fernandez-Vizarra Erika, Dufour Eric, Gizatullina Zemfira, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Viscomi Carlo, Gellerich Frank Norbert, Moore Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Laouafa 2019 Acta Physiol (Oxf)2019Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255.LEAK
OXPHOS
ET
N
S
NS
ROX
CIV
Permeabilized tissueRatNervous system
Sonjak 2019 J Gerontol A Biol Sci Med Sci2019Sonjak V, Jacob KJ, Spendiff S, Vuda M, Perez A, Miguez K, Minozzo FC, Spake C, Morais JA, Hepple RT (2019) Reduced mitochondrial content, elevated ROS, and modulation by denervation in skeletal muscle of pre-frail/frail elderly women. J Gerontol A Biol Sci Med Sci 74:1887-95.LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Cedrone 2019 Thesis2019Cedrone M (2019) Low birth weight and post-natal diet induced alterations in skeletal muscle oxygen consumption and fiber type composition. Master's Thesis 83.LEAK
OXPHOS
N
S
Permeabilized tissue
Intact cells
Guinea pig
Mouse
Skeletal muscle
Braganza 2019 JCI Insight2019Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248.LEAK
OXPHOS
ET
ROUTINE
N
NS
Permeabilized tissue
Intact cells
HumanSkeletal muscle
Blood cells
Platelet
Cooper 2019 Exp Physiol2019Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2019) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.LEAK
OXPHOS
ET
F
N
Permeabilized tissueMouseNervous system
Mitroshina 2019 Oxid Med Cell Longev2019Mitroshina EV, Mishchenko TA, Shirokova OM, Astrakhanova TA, Loginova MM, Epifanova EA, Babaev AA, Tarabykin VS, Vedunova MV (2019) Intracellular neuroprotective mechanisms in neuron-glial networks mediated by glial cell line-derived neurotrophic factor. Oxid Med Cell Longev 2019:1036907.LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseNervous system
Wessels 2019 Obesity (Silver Spring)2019Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanFat
Doerrier 2019 MitoFit Preprint Arch EA2019Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Trevino 2019 Am J Physiol Endocrinol Metab2019Trevino MB, Zhang X, Standley RA, Wang M, Han X, Reis FCG, Periasamy M1, Yu G, Kelly DP, Goodpaster BH, Vega RB, Coen PM (2019) Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. Am J Physiol Endocrinol Metab 317:E899-910.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Simon 2019 J Biol Chem2019Simon MC, Reinbeck AL, Wessel C, Heindirk J, Jelenik T, Kaul K, Arreguin-Cano J, Strom A, Blaut M, Bäckhed F, Burkart V, Roden M (2019) Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in non-obese diabetic mice. J Biol Chem 295:969-80.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Liver
MiPNet12.01 Suppl T-issue2018-11-18
O2k-Protocols contents
MitoPathways at the Q-junction: mouse skeletal muscle fibers.
LEAK
ROUTINE
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
MiPNet21.06 SUIT RP2018-06-25
O2k-Protocols
SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
MiPNet21.17 BloodCellsIsolation2018-04-09
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Ale-Agha 2018 PLOS Biol2018Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Köhrer K, Deenen R, Unfried K, Altschmied J, Haendeler J (2018) CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system - New mode of action for caffeine. PLOS Biol 6:e2004408.OXPHOSN
S
CIV
Isolated mitochondriaMouseHeart
Martins 2018 Oxid Med Cell Longev2018Martins IK, de Carvalho NR, Macedo GE, Rodrigues NR, Ziech CC, Vinadé L, Filho VMB, Menezes IA, Franco J, Posser T (2018) Anacardium microcarpum promotes neuroprotection dependently of AKT and ERK phosphorylation but does not prevent mitochondrial damage by 6-OHDA. Oxid Med Cell Longev 2018:2131895.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateChickenNervous system
Sokolov 2018 Mitochondrion2018Sokolov EP, Sokolova IM (2018) Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45:29-37.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMolluscsLung;gill
Kamunde 2018 Free Radic Biol Med2018Kamunde C, Sharaf M, MacDonald N (2018) H2O2 metabolism in liver and heart mitochondria: Low emitting-high scavenging and high emitting-low scavenging systems. Free Radic Biol Med 124:135-48.LEAKN
ROX
Isolated mitochondriaFishesHeart
Liver
Kang 2018 Exp Mol Med2018Kang YC, Son M, Kang S, Im S, Piao Y, Lim KS, Song MY, Park KS, Kim YH, Pak YK (2018) Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson's disease models. Exp Mol Med 50:105.OXPHOSNIsolated mitochondriaHumanNervous system
Goncalves 2018 Life Sci2018Gonçalves DF, de Carvalho NR, Leite MB, Courtes AA, Hartmann DD, Stefanello ST, da Silva IK, Franco JL, Soares FAA, Dalla Corte CL (2018) Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics. Life Sci 193:234-41.LEAK
OXPHOS
N
S
NS
ROX
HomogenateMouseLiver
Zimin 2018 Br J Anaesth2018Zimin PI, Woods CB, Kayser EB, Ramirez JM, Morgan PG, Sedensky MM (2018) Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I. Br J Anaesth 120:1019-32.OXPHOS
LEAK
N
S
ROX
Isolated mitochondriaMouseNervous system
Stein 2018 Cell Rep2018Stein CS, Jadiya P, Zhang X, McLendon JM, Abouassaly GM, Witmer NH, Anderson EJ, Elrod JW, Boudreau RL (2018) Mitoregulin: A lncRNA-encoded microprotein that supports mitochondrial supercomplexes and respiratory efficiency. Cell Rep 23:3710-20.LEAK
OXPHOS
F
N
Permeabilized tissueHumanHeart
Skeletal muscle
Fink 2018 J Biol Chem2018Fink BD, Bai F, Yu L, Sheldon RD, Sharma A, Taylor EB, Sivitz WI (2018) Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. J Biol Chem 293:19932-41.OXPHOSN
S
NS
Isolated mitochondriaMouseSkeletal muscle
Oemer 2018 Proc Nat Acad Sci U S A2018Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Rajkumar 2018 Metabolism2018Rajkumar A, Liaghati A, Chan J, Lamothe G, Dent R, Doucet É, Rabasa-Lhoret R, Prud'homme D, Harper ME, Tesson F (2018) ACSL5 genotype influence on fatty acid metabolism: a cellular, tissue, and whole-body study. Metabolism 83:271-9.OXPHOS
ET
F
N
CIV
NS
Permeabilized cellsHuman
Mouse
Skeletal muscle
Other cell lines
Paech 2018b Toxicology2018Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology 409:13-23.LEAK
OXPHOS
ET
N
S
DQ
CIV
ROX
NS
Isolated mitochondriaMouseLiver
Wang 2018 J Nutr Biochem2018Wang Y, Fouret G, Bonafos B, Blachnio-Zabielska A, Leroy T, Crouzier D, Barea B, Gaillet S, Moro C, Lecomte J, Coudray C, Feillet-Coudray C (2018) Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats. J Nutr Biochem 64:182-97.OXPHOS
LEAK
N
NS
Isolated mitochondriaRatSkeletal muscle
Chen 2018 Endocrinology2018Chen Y, McCommis KS, Ferguson D, Hall AM, Harris CA, Finck BN (2018) Inhibition of the mitochondrial pyruvate carrier by tolylfluanid. Endocrinology 159:609-21.OXPHOSN
NS
Isolated mitochondriaMouseFat
Rampello 2018 Microb Cell2018Rampello NG, Stenger M, Westermann B, Osiewacz HD (2018) Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging. Microb Cell 5:198–207.OXPHOSN
CIV
Isolated mitochondriaFungi
Ost 2018 Curr Opin Clin Nutr Metab Care2018Ost M, Doerrier C, Gama-Perez P, Moreno-Gomez S (2018) Analysis of mitochondrial respiratory function in tissue biopsies and blood cells. Curr Opin Clin Nutr Metab Care 21:336-42.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Intact cells
Blood cells
Platelet
Skeletal muscle
Liver
Fat
Siira 2018 EMBO Rep2018Siira SJ, Rossetti G, Richman TR, Perks K, Ermer JA, Kuznetsova I, Hughes L, Shearwood AJ, Viola HM, Hool LC, Rackham O, Filipovska A (2018) Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z. EMBO Rep 19:e46198.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Scaini 2018 Eur Neuropsychopharmacol2018Scaini G, Quevedo J, Velligan D, Roberts DL, Raventos H, Walss-Bass C (2018) Second generation antipsychotic-induced mitochondrial alterations: Implications for increased risk of metabolic syndrome in patients with schizophrenia. Eur Neuropsychopharmacol 28:369-80.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Lymphocyte
Robb 2018 J Biol Chem2018Robb EL, Hall AR, Prime TA, Eaton S, Szibor M, Viscomi C, James AM, Murphy MP (2018) Control of mitochondrial superoxide production by reverse electron transport at complex I. J Biol Chem 293:9869-79.ETN
S
ROX
Isolated mitochondriaRatHeart
Von Schulze 2018 J Physiol2018Von Schulze A, McCoin CS, Onyekere C, Allen J, Geiger P, Dorn GW, Morris EM, Thyfault JP (2018) Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α, and BNIP3 mediated mitophagy. J Physiol 596:6157-71.OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
Ko 2018 Pflugers Arch2018Ko TH, Marquez JC, Kim HK, Jeong SH, Lee S, Youm JB, Song IS, Seo DY, Kim HJ, Won DN, Cho KI, Choi MG, Rhee BD, Ko KS, Kim N, Won JC, Han J (2018) Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts. Pflugers Arch 470:263-75.LEAK
OXPHOS
N
ROX
Isolated mitochondriaRatHeart
McLaughlin 2018 Biochem Biophys Res Commun2018McLaughlin KL, McClung JM, Fisher-Wellman KH (2018) Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart. Biochem Biophys Res Commun 504:742-48.N
S
F
Isolated mitochondriaMouseHeart
Fouret 2018 Br J Nutr2018Fouret G, Gaillet S, Lecomte J, Bonafos B, Djohan F, Barea B, Badia E, Coudray C, Feillet-Coudray C (2018) 20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet. Br J Nutr 119:368-80.OXPHOSN
NS
RatLiver
Logan 2018 Thesis2018Logan C (2018) Nitrate and nitrite differentially affect respiration in zebrafish during exercise. Honors Baccalaureate of Science in Nutrition p44.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaZebrafishSkeletal muscle
Dohlmann 2018 Physiol Rep2018Dohlmann TL, Hindsø M, Dela F, Helge JW, Larsen S (2018) High-intensity interval training changes mitochondrial respiratory capacity differently in adipose tissue and skeletal muscle. Physiol Rep 6:e13857.OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
Fat
McWilliams 2018 Open Biol2018McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK (2018) Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol 8:180108.LEAK
OXPHOS
ET
NHomogenateMouseNervous system
Cardinale 2018 Physiol Rep2018Cardinale DA, Gejl KD, Ørtenblad N, Ekblom B, Blomstrand E, Larsen FJ (2018) Reliability of maximal mitochondrial oxidative phosphorylation in permeabilized fibers from the vastus lateralis employing high-resolution respirometry. Physiol Rep 6. doi: 10.14814/phy2.13611.LEAK
OXPHOS
F
N
Permeabilized tissueHumanSkeletal muscle
Wuest 2018 Cell Metab2018Wüst S, Dröse S, Heidler J, Wittig I, Klockner I, Franko A, Bonke E, Günther S, Gärtner U, Boettger T, Braun T (2018) Metabolic maturation during muscle stem cell differentiation is achieved by miR-1/133a-mediated inhibition of the Dlk1-Dio3 mega gene cluster. Cell Metab 27:1026-39.OXPHOSN
S
CIV
Intact cellsMouseSkeletal muscle
Gam 2018 Acta Diabetol2018Gam CMBF, Mortensen OH, Larsen LH, Poulsen SS, Qvortrup K, Mathiesen ER, Damm P, Quistorff B (2018) Diabetes, myometrium, and mitochondria in pregnant women at term. Acta Diabetol 55:999-1010.LEAK
OXPHOS
F
N
S
NS
Isolated mitochondriaHumanGenital
Real-Hohn 2018 bioRxiv2018Real-Hohn A, Navegantes C, Ramos K, Ramos-Filho D, Cahuê F, Galina A, Salerno V (2018) Hexokinase: a central player in the synergism of high-intensity intermittent exercise and every-other-day intermittent fasting regimen on energy metabolism adaptations. bioRxiv doi: https://doi.org/10.1101/389668.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueRatSkeletal muscle
Fox 2018 Thesis2018Fox JC (2018) FROST450, a novel microtubule targeting agent: resistance and cross-resistance in an ovarian cancer cell line. Bachelor's Thesis 27.LEAK
OXPHOS
ET
N
NS
ROX
Intact cellsHumanGenital
Leckey 2018 FASEB J2018Leckey JJ, Hoffman NJ, Parr EB, Devlin BL, Trewin AJ, Stepto NK, Morton JP, Burke LM, Hawley JA (2018) High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J 32:2979-91.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Krug 2018 Thesis2018Krug KP (2018) Adaptation of metabolism and respiratory chain functions in pulmonary arterial vascular muscle cells under chronic hypoxia: especially considering the cytochrome c oxidase subunit 4 isoform 2. Doctoral Dissertation 136.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
ROX
Intact cells
Permeabilized cells
RatOther cell lines
Chung 2018 J Exp Biol2018Chung DJ, Sparagna GC, Chicco AJ, Schulte PM (2018) Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J Exp Biol 221. pii: jeb174458.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Isolated mitochondriaFishesLiver
Britto 2018 BMC Biol2018Britto FA, Cortade F, Belloum Y, Blaquière M, Gallot YS, Docquier A, Pagano AF, Jublanc E, Bendridi N, Koechlin-Ramonatxo C, Chabi B, Francaux M, Casas F, Freyssenet D, Rieusset J, Giorgetti-Peraldi S, Carnac G, Ollendorff V, Favier FB (2018) Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress. BMC Biol 16:65.LEAK
OXPHOS
F
N
NS
Other combinations
Permeabilized cells
Isolated mitochondria
MouseSkeletal muscle
Francisco 2018 J Neurochem2018Francisco A, Ronchi JA, Navarro CDC, Figueira TR, Castilho RF (2018) Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. J Neurochem 147:663-77.LEAK
OXPHOS
NIsolated mitochondriaMouseNervous system
Magnifico 2018 Oxid Med Cell Longev2018Magnifico MC, Xhani M, Popov M, Saso L, Sarti P, Arese M (2018) Nonylphenol and octylphenol differently affect cell redox balance by modulating the nitric oxide signaling. Oxid Med Cell Longev 2018:1684827.ROUTINE
OXPHOS
N
S
CIV
ROX
Permeabilized cells
Intact cells
HumanLiver
Other cell lines
Martinez 2018 Arch Biochem Biophys2018Martínez JH, Fuentes F, Vanasco V, Alvarez S, Alaimo A, Cassina A, Coluccio Leskow F, Velazquez F (2018) Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment. Arch Biochem Biophys 651:1-12.LEAK
OXPHOS
ET
N
S
ROX
Isolated mitochondriaRatNervous system
Burney 2018 Thesis2018Burney E (2018) Characterization of mitochondrial metabolism in L6 rat myoblasts. Bachelor's Thesis p50.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Intact cells
RatOther cell lines
Lo 2018 Am J Physiol Renal Physiol2018Lo S, MacMillan-Crow LA, Parajuli N (2018) Renal cold storage followed by transplantation impairs proteasome function and subsequently mitochondrial protein homeostasis. Am J Physiol Renal Physiol 316:F42-F53.OXPHOS
LEAK
N
S
ROX
Permeabilized cellsRatKidney
Other cell lines
Davis 2018 FASEB J2018Davis RAH, Deemer SE, Bergeron JM, Little JT, Warren JL, Fisher G, Smith DL Jr, Fontaine KR, Dickinson SL, Allison DB, Plaisance EP (2018) Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet. FASEB J 33:2409-21.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Martins 2018 Comp Biochem Physiol B Biochem Mol Biol2018Martins EL, Ricardo JC, de-Souza-Ferreira E, Camacho-Pereira J, Ramos-Filho D, Galina A (2018) Rapid regulation of substrate use for oxidative phosphorylation during a single session of high intensity interval or aerobic exercises in different rat skeletal muscles. Comp Biochem Physiol B Biochem Mol Biol 217:40-50.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Kauppila 2018 Nucleic Acids Res2018Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouse
Brouwers 2018 Front Physiol2018Brouwers B, Stephens NA, Costford SR, Hopf ME, Ayala JE, Yi F, Xie H, Li JL, Gardell SJ, Sparks LM, Smith SR (2018) Elevated nicotinamide phosphoribosyl transferase in skeletal muscle augments exercise performance and mitochondrial respiratory capacity following exercise training. Front Physiol 9:704.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Kim 2018 Pflugers Arch2018Kim Y, Triolo M, Erlich AT, Hood DA (2018) Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations. Pflugers Arch 471:431-40.OXPHOSN
NS
Permeabilized tissueRatSkeletal muscle
Wu 2018 Adv Sci2018Wu S, Zhang A, Li S, Chatterjee S, Qi R, Segura-Ibarra V, Ferrari M, Gupte A, Blanco E, Hamilton DJ (2018) Polymer functionalization of isolated mitochondria for cellular transplantation and metabolic phenotype alteration. Adv Sci 1700530.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseLiver
Mendes 2018 Mol Neurobiol2018Mendes Lima JP, Rayêe D, Silva-Rodrigues T, Ribeiro Paes Pereira P, Mendonca APM, Rodrigues-Ferreira C, Szczupak D, Fonseca A, Oliveira MF, Souza Lima FR, Lent R, Galina A, Uziel D (2018) Perinatal asphyxia and brain development: mitochondrial damage without anatomical or cellular losses. Mol Neurobiol doi.org/10.1007/s12035-018-1019-7.LEAK
ROUTINE
ET
N
NS
ROX
Intact cellsRatNervous system
Salin 2018 Integr Comp Biol2018Salin K, Villasevil EM, Anderson GJ, Selman C, Chinopoulos C, Metcalfe NB (2018) The RCR and ATP/O indices can give contradictory messages about mitochondrial efficiency. Integr Comp Biol 58:486-94.LEAK
OXPHOS
N
S
NS
ROX
HomogenateFishesLiver
Wilmanns 2018 Mol Metab2018Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW (2018) Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Mol Metab 20:102-14.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueMouseHeart
Apostolopoulou 2018 Thesis2018Apostolopoulou M (2018) Determinants of insulin sensitivity in obesity and recent-onset type 2 diabetes mellitus. PhD Thesis 77.OXPHOS
ET
F
N
NS
Homogenate
Isolated mitochondria
HumanLiver
Flis 2018 Oxid Med Cell Longev2018Flis DJ, Dzik K, Kaczor JJ, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2018) Swim training modulates skeletal muscle energy metabolism, oxidative stress, and mitochondrial cholesterol content in amyotrophic lateral sclerosis mice. Oxid Med Cell Longev 5940748.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Rundle 2018 Environ Sci Technol2018Rundle K, Sharaf M, Stevens D, Kamunde C, Van Den Heuvel MR (2018) Oil sands-derived naphthenic acids are oxidative uncouplers and impair electron transport in isolated mitochondria. Environ Sci Technol 52:10803-11.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaFishesLiver
Pardo 2018 FASEB J2018Pardo R, Vilà M, Cervela L, de Marco M, Gama-Pérez P, González-Franquesa A, Statuto L, Vilallonga R, Simó R, Garcia-Roves PM, Villena JA (2018) Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue. FASEB J 33:2343-58.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseFat
Niu 2018 Cancer Metab2018Niu X, Chen YJ, Crawford PA, Patti GJ (2018) Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells. Cancer Metab 6:19.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaHumanHeLa
Karlsson 2018 J Neurotrauma2018Karlsson M, Pukenas B, Chawla S, Ehinger JK, Plyler R, Stolow M, Gabello M, Hugerth M, Elmér E, Hansson MJ, Margulies S, Kilbaugh T (2018) Neuroprotective effects of cyclosporine in a porcine pre-clinical trial of focal traumatic brain injury. J Neurotrauma [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenatePigNervous system
Goncalves 2018 Neurotoxicology2018Gonçalves DF, Courtes AA, Hartmann DD, da Rosa PC, Oliveira DM, Soares FAA, Dalla Corte CL (2018) 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. Neurotoxicology 70:1-11.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatNervous system
Stepanova 2018 J Neurochem2018Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A (2018) The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem 148:731-45.LEAK
OXPHOS
N
S
Gp
NS
ROX
Isolated mitochondriaMouseNervous system
Geffroy 2018 Biochim Biophys Acta2018Geffroy G, Benyahia R, Frey S, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Inisan A, Renaud A, Chevrollier A, Henrion D, Bonneau D, Letournel F, Lenaers G, Reynier P, Procaccio V (2018) The accumulation of assembly intermediates of the mitochondrial complex I matrix arm is reduced by limiting glucose uptake in a neuronal-like model of MELAS syndrome. Biochim Biophys Acta 1864:1596-1608.ROUTINE
ET
NIntact cellsHumanNervous system
Other cell lines
Marini 2018 Proc Natl Acad Sci U S A2018Marini A, Rotblat B, Sbarrato T, Niklison-Chirou MV, Knight JRP, Dudek K, Jones C, Bushell M, Knight RA, Amelio I, Willis AE, Melino G (2018) TAp73 contributes to the oxidative stress response by regulating protein synthesis. Proc Natl Acad Sci U S A 115:6219-24.OXPHOSNHomogenateHumanKidney
Lung;gill
HEK
Barbeau 2018 Biochem J2018Barbeau PA, Miotto PM, Holloway GP (2018) Mitochondrial derived reactive oxygen species influence ADP sensitivity, but not CPT-I substrate sensitivity. Biochem J 475:2997-3008.OXPHOSF
N
NS
Permeabilized tissueMouseSkeletal muscle
De Moura Alvorcem 2018 Mitochondrion2018De Moura Alvorcem L, Britto R, Parmeggiani B, Glanzel NM, Da Rosa-Junior NT, Cecatto C, Bobermin LD, Amaral AU, Wajner M, Leipnitz G (2018) Evidence that thiol group modification and reactive oxygen species are involved in hydrogen sulfide-induced mitochondrial permeability transition pore opening in rat cerebellum. Mitochondrion 47:141-50.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondria
Intact cells
RatNervous system
Jang 2018 Intensive Care Med Exp2018Jang DH, MD, Khatri UG, Shortal BP, Kelly M, Lambert DS, Hardy K, Eckmann DM (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 6:4.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanBlood cells
Jang 2018 J Med Toxicol2018Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM (2018) Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. J Med Toxicol 14:144-51.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Chen 2018 Hum Mol Genet2018Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26.OXPHOS
ET
F
N
S
DQ
CIV
NS
Isolated mitochondriaHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Silaidos 2018 Biol Sex Differ2018Silaidos C, Pilatus U, Grewal R, Matura S, Lienerth B, Pantel J, Eckert GP (2018) Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain. Biol Sex Differ 9:34.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanNervous system
Blood cells
Sims 2018 JCI Insight2018Sims CA, Guan Y, Mukherjee S, Singh K, Botolin P, Davila A Jr, Baur JA (2018) Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock. JCI Insight 3:120182.OXPHOSN
S
CIV
ROX
Permeabilized cells
Isolated mitochondria
RatLiver
Kidney
Falcao-Tebas 2018 J Physiol2018Falcão-Tebas F, Kuang J, Arceri C, Kerris JP, Andrikopoulos S, Marin EC, McConell GK (2018) Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by paternal high fat diet. J Physiol 597:121-36.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatSkeletal muscle
Manoharan 2018 Thesis2018Manoharan N (2018) Characterization of mitochondrial respiration in atlantic salmon (Salmo salar) fed with glutamate and succinate enhanced diet. Master's Thesis 52.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateFishesHeart
Liver
Perks 2018 Cell Rep2018Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42.LEAK
OXPHOS
ET
N
Gp
S
Isolated mitochondriaMouseHeart
Casal 2018 J Anim Sci2018Casal A, Garcia-Roche M, Navajas EA, Cassina A, Carriquiry M (2018) Hepatic mitochondrial function in Hereford steers with divergent residual feed intake phenotypes. J Anim Sci 96:4431-43.LEAK
OXPHOS
ET
N
S
ROX
Intact cellsBovinesLiver
Tsuda 2018 J Cachexia Sarcopenia Muscle2018Tsuda M, Fukushima A, Matsumoto J, Takada S, Kakutani N, Nambu H, Yamanashi K, Furihata T, Yokota T, Okita K, Kinugawa S, Anzai T (2018) Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure. J Cachexia Sarcopenia Muscle 9:844-59.OXPHOS
LEAK
F
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Valentine 2018 J Gerontol A Biol Sci Med Sci2018Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N (2018) NFκB regulates muscle development and mitochondrial function. J Gerontol A Biol Sci Med Sci 75:647-53.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Docherty 2018 Atherosclerosis2018Docherty CK, Carswell A, Friel E, Mercer JR (2018) Impaired mitochondrial respiration in human carotid plaque atherosclerosis: A potential role for Pink1 in vascular smooth muscle cell energetics. Atherosclerosis 268:1-11.OXPHOSN
CIV
NS
ROX
Permeabilized tissueHumanEndothelial;epithelial;mesothelial cell
Urazov 2018 Sovrem Tekhnologii Med2018Urazov MD, Astrakhanova TA, Usenko AV, Mishchenko TA, Schelchkova NA, Kravchenko GA, Vedunova MV, Mitroshina EV (2018) New aspects of central nervous system adaptation to prenatal hypoxia. Sovrem Tekhnologii Med 10:60-68.OXPHOS
LEAK
N
S
NS
Isolated mitochondriaMouseNervous system
Holloway 2018 Cell Rep2018Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018) Age-associated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837–48.OXPHOS
ET
LEAK
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Kappler 2018 Thesis2018Kappler L (2018) Method development for valid high‐resolution profiling of mitochondria and Omics investigation of mitochondrial adaptions to excess energy intake and physical exercise. Dissertation p181.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Skeletal muscle
Liver
Other cell lines
Hancock 2018 Elife2018Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M (2018) Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. Elife 7:e41044.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Arena 2018 Mol Cell2018Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 69:594-609.OXPHOSN
S
NS
Permeabilized cellsHumanLung;gill
Other cell lines
Mkrtchyan 2018 Biochim Biophys Acta2018Mkrtchyan GV, Üçal M, Müllebner A, Dumitrescu S, Kames M, Moldzio R, Molcanyi M, Schaefer S, Weidinger A, Schaefer U, Hescheler J, Duvigneau JC, Redl H, Bunik VI, Kozlov AV (2018) Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex. Biochim Biophys Acta 1859:925-31.OXPHOSN
S
HomogenateRatNervous system
Miotto 2018 Thesis2018Miotto PM (2018) The influence of exercise and high fat feeding on the regulation of mitochondrial substrate sensitivity in skeletal muscle. PhD Thesis p185.OXPHOSF
N
NS
Permeabilized cellsMouseSkeletal muscle
Angebault 2018 Sci Signal2018Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380.LEAK
OXPHOS
N
S
NS
Permeabilized cellsHumanFibroblast
... further results