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Tang 2022 Sci China Life Sci

From Bioblast
Publications in the MiPMap
Tang G, Ma C, Li L, Zhang S, Li F, Wu J, Yin Y, Zhu Q, Liang Y, Wang R, Huang H, Zhao TJ, Yang H, Li P, Chen FJ (2022) PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure.

ยป Sci China Life Sci 65:2287-300. PMID: 36166181 Open Access

Tang Guoqing, Ma Chengxin, Li Liangkui, Zhang Shaoyan, Li Fengsheng, Wu Jin, Yin Yesheng, Zhu Qing, Liang Yan, Wang Ru, Huang He, Zhao Tong-Jin, Yang Hongyuan, Li Peng, Chen Feng-Jung (2022) Sci China Life Sci

Abstract: Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers phospholipids between intracellular membrane structures. However, the physiological significance of PITPNC1 and its regulatory mechanism remain unclear. Here, we demonstrate that PITPNC1 is a key player in thermogenesis of BAT. While Pitpnc1-/- mice do not differ with wildtype mice in body weight and insulin sensitivity on either chow or high-fat diet, they develop hypothermia when subjected to acute cold exposure at 4ยฐC. The Pitpnc1-/- brown adipocytes exhibit defective ฮฒ-oxidation and abnormal thermogenesis-related metabolism pathways in mitochondria. The deficiency of lipid mobilization in Pitpnc1-/- brown adipocytes might be the result of excessive accumulation of phosphatidylcholine and a reduction of phosphatidic acid. Our findings have uncovered significant roles of PITPNC1 in mitochondrial phospholipid homeostasis and BAT thermogenesis. โ€ข Keywords: PITPNC1, Acute cold exposure, Lipid homeostasis, Thermogenesis, ฮฒ-oxidation โ€ข Bioblast editor: Plangger M

Labels: MiParea: Respiration, Genetic knockout;overexpression 

Organism: Mouse  Tissue;cell: Fat  Preparation: Isolated mitochondria 

Coupling state: LEAK, ET  Pathway:HRR: Oxygraph-2k