State 1

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State 1


State 1 is the first respiratory state in an oxygraphic protocol described by Chance and Williams (1955), when isolated mitochondria are added to mitochondrial respiration medium containing oxygen and inorganic phosphate, but no ADP and no reduced respiratory substrates. In State 1, LEAK respiration may be supported to some extent by undefined endogenous substrates, which are oxidized and slowly exhausted. After oxidation of endogenous substrates, only residual oxygen consumption remains (ROX).

Reference: Chance 1955 JBC-III, Gnaiger 2020 BEC MitoPathways

MitoPedia concepts: Respiratory state, Find 

MitoPedia topics: EAGLE