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Spees 2006 Proc Natl Acad Sci U S A

From Bioblast
Publications in the MiPMap
Spees JL, Olson SD, Whitney MJ, Prockop DJ (2006) Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci U S A 103:1283-8.

ยป PMID: 16432190 Open Access

Spees JL, Olson SD, Whitney MJ, Prockop DJ (2006) Proc Natl Acad Sci U S A

Abstract: Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential roles in aging and determining lifespan. A variety of heritable and acquired diseases are linked to mitochondrial dysfunction. We report here that mitochondria are more dynamic than previously considered: mitochondria or mtDNA can move between cells. The active transfer from adult stem cells and somatic cells can rescue aerobic respiration in mammalian cells with nonfunctional mitochondria. โ€ข Keywords: Horizontal mitochondrial transfer โ€ข Bioblast editor: Gnaiger E


Labels: MiParea: Respiration, mt-Structure;fission;fusion, mtDNA;mt-genetics