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...A, Stojilkovic SS, Kostic TS (2013) The opposing roles of nitric oxide and cGMP in the age-associated decline in rat testicular steroidogenesis. Endocrinol ...dogenesis in a cGMP-independent manner, whereas the sustained elevation in cGMP levels significantly slows the decline in LC function.

...px|Mitochondrial Physiology Society|MiPsociety]] Aging-related increase of cGMP disrupts mitochondrial homeostasis in Leydig cells. ...e rise of cGMP-signaling and decline in testosterone production. To target cGMP-signaling in Leydig cells, ''in vivo'' single or long-term treatment with s

|title=Effect of cGMP-dependent protein kinase (PKG) signaling on mitochondrial content in ''Dros ...uit flies carrying the Rover allele of the foraging gene (forR), express a cGMP-dependent protein kinase (PKG) with high enzymatic activity, whereas fruit

...In particular, inhibition of nNOS/NO/cyclic guanosine monophosphate (cGMP)/cGMP-dependent-protein kinases induced the transcriptional activity of FoxO3 and

...nesis and integrator of environmental signals, is stimulated by cAMP-PRKA, cGMP, and β-adrenergic receptors. Accordingly, stress-triggered mitochondrial b

...lase. Dysfunction of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) cascade is strongly linked to the neurobiology of mood, anxiety and psycho

...n store and transfer energy (by the conversion of ATP to ADP), or cAMP and cGMP, which participate in cell signalling. Some nucleotides are also incorpora

...the spatial control of mitochondrial localization. Given that nitric oxide-cGMP pathways regulate mitochondria and that sildenafil-mediated phosphodiestera

...te-mediated vasodilation was evidenced by NO gas formation, stimulation of cGMP production, and inhibition of mitochondrial respiration in a process sensit

...nesis and integrator of environmental signals, is stimulated by cAMP-PRKA, cGMP and β-adrenergic receptors. Accordingly, stress-triggered mitochondrial bi

...d subsequenced cytochrome ''c'' release. It is anticipated that NO through cGMP-dependent mechanisms can activate

Taking together, our results suggest that pharmacological targeting of cGMP-signaling could affect mitochondrial dynamics in myocardium during aging.

...s and subsequenced cytochrome c release. It is anticipated that NO through cGMP-dependent mechanisms can activate

...J Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism. BMC Biol 13:1-17.

...S]] activity -> [[MiPNet15.05_NO-manual|NO]] -> [[guanylate cyclase]] -> [[cGMP]] ([[Nisoli 2007 Circ Res]]). AMP-activated protein kinase (AMPK) increases

...e receptors. Thus BK-induced cardioprotection was blocked by inhibitors of cGMP-dependent protein kinase (PKG) or guanylyl cyclase (GC), whereas ouabain-in

...functional XOR, and this new organic nitrate elicits vasorelaxation via NO-cGMP-PKG signaling and activation of K_IR channels. Future studies sho

...ate substrates and cofactors, the signalosome is able to synthesize NO and cGMP. The ADOR inhibitor 8-SPT blocked activity, showing that the receptor itsel