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Yan 2019 Int Immunopharmacol
Additional label Labels  + , 2019-03  +
Coupling states LEAK  + , OXPHOS  +
Diseases Sepsis  +
Has abstract Sepsis-induced hepatic dysfunction is cons
Sepsis-induced hepatic dysfunction is considered as an independent risk factor of multiple organ dysfunction syndrome (MODS) and death. Mitophagy, a selective form of autophagy, plays a major role in sepsis-induced organ damage. We have demonstrated that hydrogen gas (H<sub>2</sub>), a selective antioxidant, exerts protective effects in septic mice. Here, we hypothesize that the therapeutic effects of H<sub>2</sub> on septic animals with liver damages may be exerted through regulation of the Fun14 domain-containing protein 1 (FUDNC1)-induced mitophagy pathway. Male C57BL/6J mice were subjected to sham or cecal ligation and puncture (CLP) operation and treated with 2% H<sub>2</sub> gas inhalation for 3 h starting at 1 h after sham or CLP surgery. To verify the role of FUNDC1, the cell-penetrating peptide P (NH2-GRKKRRQRRRPQDYESDDESYEVLDLTEY-COOH) (1 mg/kg) that functions as a FUNDC1 inhibitor was intraperitoneally injected into mice 24 h before the sham or CLP operation. To evaluate the severity of septic liver injury, the 7-day survival rate, liver histopathologic score, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, respiration control ratio (RCR), and FUDNC1, P-18-FUDNC1, P62, LC3B-II, Tim23, and caspase-1 levels were evaluated after the sham or CLP operation. The results demonstrated that 2% H<sub>2</sub> gas inhalation resulted in an increase in the 7-day survival rate, ALT and AST levels, RCR, and P62 and LC3B-II expression but decreased the histological score and FUDNC1, P-18-FUDNC1, Tim23, and caspase-1 levels after sepsis. However, no significant differences were reported between the CLP + peptide P and CLP + H<sub>2</sub> + peptide P groups. These observations indicate that 2% H<sub>2</sub> gas inhalation for 3 h may serve as an effective therapeutic strategy for sepsis-induced liver injury through the regulation of FUNDC1-dependent mitophagy. <small>Copyright © 2019 Elsevier B.V. All rights reserved.</small>
er B.V. All rights reserved.</small>  +
Has editor [[Plangger M]]  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/30877875 PMID: 30877875]  +
Has publicationkeywords FUNDC1  + , Hydrogen gas  + , Liver injury  + , Mitophagy  + , Sepsis  +
Has title Yan M, Yu Y, Mao X, Feng J, Wang Y, Chen H, Xie K, Yu Y (2019) Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner. Int Immunopharmacol 71:61-7.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Pharmacology;toxicology  +
Pathways S  +
Preparation Isolated mitochondria  +
Tissue and cell Liver  +
Was published in journal Int Immunopharmacol +
Was published in year 2019  +
Was written by Yan M + , Yu Y + , Mao X + , Feng J + , Wang Y + , Chen H + , Xie K +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
13:09:50, 21 March 2019  +
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