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Rossignoli 2018 J Nutr Biochem
Additional label 2018-08  +
Coupling states ET  + , LEAK  + , OXPHOS  +
Enzyme Uncoupling protein  +
Has abstract Understanding the mitochondrial processes
Understanding the mitochondrial processes that contribute to body energy metabolism may provide an attractive therapeutic target for obesity and co-morbidities. Here we investigated whether intermittent dietary supplementation with conjugated linoleic (CLA, 18:2n-6), docosahexaenoic (22:6n-3, DHA) and eicosapentaenoic (20:5n-3, EPA) acids, either alone or in combination, changes body metabolism associated with mitochondrial functions in the brain, liver, skeletal muscle and brown adipose tissue (BAT). Male C57Bl/6 mice were divided into groups: CLA (50% cis-9, trans-11; 50% trans-10, cis-12), EPA/DHA (64% EPA; 28% DHA), CLA plus EPA/DHA or control (linoleic acid). Each mouse received 3 g/kg b.w. of the stated oil by gavage on alternating days for 60 days. Dietary supplementation with CLA or EPA/DHA increased body VO<sub>2</sub> consumption, VCO<sub>2</sub> production and energy expenditure, being fish oil (FO) the most potent even in combination with CLA. Individually, both oils reduced mitochondrial density in BAT. CLA supplementation alone also a) elevated the expression of uncoupling proteins in soleus, liver and hippocampus and the uncoupling activity in the last two, ad this effect was associated with reduced hydrogen peroxide production in hippocampus; b) increased proteins related to mitochondrial fission in liver. EPA/DHA supplementation alone also a) induced mitochondrial biogenesis in liver, soleus and hippocampus associated with increased expression of PGC1-α; b) induced proteins related to mitochondrial fusion in the liver, and fission and fusion in the hippocampus. Therefore, this study shows changes on mitochondrial mechanisms induced by CLA and/or EPA/DHA that can be associated with elevated body energy expenditure.
ted with elevated body energy expenditure.  +
Has editor [[Plangger M]]  +
Has info [ PMID: 30041048]  +
Has publicationkeywords Body metabolism  + , Conjugated linoleic acid  + , Docosapentaenoic acid  + , Eicosapentaenoic acid  + , Mitochondrial biogenesis  + , Omega-3 polyunsaturated fatty acids  + , Uncoupling protein  +
Has title Rossignoli CP, Dechandt CRP, Souza AO, Sam
Rossignoli CP, Dechandt CRP, Souza AO, Sampaio IH, Vicentini TM, Teodoro BG, Neto MPC, Ferrari GD, Couto-Lima CA, Alberici LC (2018) Effects of intermittent dietary supplementation with conjugated linoleic acid and fish oil (EPA/DHA) on body metabolism and mitochondrial energetics in mice. J Nutr Biochem 60:16-23.
ergetics in mice. J Nutr Biochem 60:16-23.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Exercise physiology;nutrition;life style  + , Respiration  + , mt-Biogenesis;mt-density  +
Pathways N  + , S  +
Preparation Isolated mitochondria  + , Permeabilized cells  +
Respiration and regulation Fatty acid  +
Tissue and cell Fat  + , Liver  + , Nervous system  + , Skeletal muscle  +
Was published in journal J Nutr Biochem +
Was published in year 2018  +
Was written by Rossignoli CP + , Dechandt CRP + , Souza AO + , Sampaio IH + , Vicentini TM + , Teodoro BG + , Neto MPC + , Ferrari GD + , Couto-Lima CA + , Alberici LC +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
09:20:22, 30 August 2018  +
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