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Munro 2019 Aging Cell
Additional label 2019-02  + , Amplex UltraRed  +
Coupling states LEAK  + , OXPHOS  +
Diseases Aging;senescence  +
Enzyme Complex I  + , Complex II;succinate dehydrogenase  + , Complex IV;cytochrome c oxidase  +
Has abstract Naked mole-rats (NMRs) are mouse-sized mam
Naked mole-rats (NMRs) are mouse-sized mammals that exhibit an exceptionally long lifespan (>30 vs. <4 years for mice), and resist aging-related pathologies such as cardiovascular and pulmonary diseases, cancer, and neurodegeneration. However, the mechanisms underlying this exceptional longevity and disease resistance remain poorly understood. The oxidative stress theory of aging posits that (a) senescence results from the accumulation of oxidative damage inflicted by reactive oxygen species (ROS) of mitochondrial origin, and (b) mitochondria of long-lived species produce less ROS than do mitochondria of short-lived species. However, comparative studies over the past 28 years have produced equivocal results supporting this latter prediction. We hypothesized that, rather than differences in ROS generation, the capacity of mitochondria to consume ROS might distinguish long-lived species from short-lived species. To test this hypothesis, we compared mitochondrial production and consumption of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>; as a proxy of overall ROS metabolism) between NMR and mouse skeletal muscle and heart. We found that the two species had comparable rates of mitochondrial H<sub>2</sub>O<sub>2</sub> generation in both tissues; however, the capacity of mitochondria to consume ROS was markedly greater in NMRs. Specifically, maximal observed consumption rates were approximately two and fivefold greater in NMRs than in mice, for skeletal muscle and heart, respectively. Our results indicate that differences in matrix ROS detoxification capacity between species may contribute to their divergence in lifespan. <small>© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.</small>
d John Wiley & Sons Ltd.</small>  +
Has editor [[Plangger M]]  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/30768748 PMID: 30768748 Open Access]  +
Has publicationkeywords Antioxidants  + , Heterocephalus glaber  + , Mitochondria  + , Reactive oxygen species  + , Skeletal muscle heart  +
Has title Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.  +
Instrument and method O2k-Fluorometer  + , Oxygraph-2k  +
Mammal and model Mouse  + , Other mammals  +
MiP area Comparative MiP;environmental MiP  + , Respiration  +
Pathways N  + , NS  + , S  +
Preparation Isolated mitochondria  +
Stress Oxidative stress;RONS  +
Tissue and cell Heart  + , Skeletal muscle  +
Was published by MiPNetLab CA Winnipeg Treberg JR +
Was published in journal Aging Cell +
Was published in year 2019  +
Was written by Munro D + , Baldy C + , Pamenter M + , Treberg JR +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
10:47:33, 23 May 2019  +
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