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McCoin 2019 Am J Physiol Endocrinol Metab
Additional label Labels  + , 2019-05  +
Coupling states LEAK  + , OXPHOS  + , ET  +
Diseases Other  +
Has abstract The impact of sexual dimorphism and mitoph
The impact of sexual dimorphism and mitophagy on hepatic mitochondrial adaptations during the treatment of steatosis with physical activity are largely unknown. Here, we tested if deficiencies in liver-specific PGC-1a, a transcriptional co-activator of biogenesis, and BNIP3, a mitophagy regulator, would impact hepatic mitochondrial adaptations (respiratory capacity, H<sub>2</sub>O<sub>2</sub> production, mitophagy) to a high-fat diet (HFD) and HFD plus physical activity via voluntary wheel running (VWR) in both sexes. Male and female wild type (WT), liver-specific PGC-1a heterozygote (LPGC-1a) and BNIP3 null mice were thermoneutral housed (29-31°C) and divided into three groups: sedentary - low fat diet (LFD), 16 weeks of (HFD), or 16 weeks of HFD with VWR for the final 8 weeks (HFD+VWR) (n=5-7/sex/group). HFD did not impair mitochondrial respiratory capacity or coupling in any group, however HFD+VWR significantly increased maximal respiratory capacity only in WT and PGC-1a females. Males required VWR to elicit mitochondrial adaptations that were inherently present in sedentary females including greater mitochondrial coupling efficiency and reduced H<sub>2</sub>O<sub>2</sub> production. Females had overall reduced markers of mitophagy, steatosis, and liver damage. Steatosis and markers of liver injury were present in sedentary male mice on the HFD and were effectively reduced with VWR despite no resolution of steatosis. Overall, reductions in PGC-1a and loss of BNIP3 only modestly impacted mitochondrial adaptations to HFD and HFD+VWR with the biggest effect seen in BNIP3 females. In conclusion, hepatic mitochondrial adaptations to HFD and treatment of HFD-induced steatosis with VWR are more dependent on sex than PGC-1a or BNIP3.
ore dependent on sex than PGC-1a or BNIP3.  +
Has editor [[Plangger M]]  +
Has info [ PMID: 31039007]  +
Has publicationkeywords Liver  + , Metabolism  + , Mitochondrial respiratory capacity  + , Mitophagy  + , Reactive oxygen species  +
Has title McCoin CS, Von Schulze A, Allen J, Fuller
McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab 317:E298-E311.
J Physiol Endocrinol Metab 317:E298-E311.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Gender  + , Exercise physiology;nutrition;life style  +
Pathways F  + , N  + , NS  +
Preparation Isolated mitochondria  +
Tissue and cell Liver  +
Was published by MiPNetLab US KS Kansas City Thyfault JP +
Was published in journal Am J Physiol Endocrinol Metab +
Was published in year 2019  +
Was written by McCoin C + , Von Schulze A + , Allen J + , Fuller KN + , Xia Q + , Koestler DC + , Houchen CJ + , Maurer A + , Dorn Ii GW + , Shankar K + , Morris EM + , Thyfault JP +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
13:23:42, 15 October 2019  +
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