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Khamoui 2018 J Dev Orig Health Dis
Additional label Labels  + , 2018-08  +
Coupling states LEAK  + , OXPHOS  + , ET  +
Has abstract Exposure to maternal over-nutrition ''in u
Exposure to maternal over-nutrition ''in utero'' is linked with developmental programming of obesity, metabolic syndrome and cardiovascular disease in offspring, which may be exacerbated by postnatal high-fat (HF) diet. Skeletal muscle mitochondrial function contributes to substrate metabolism and is impaired in metabolic disease. We examined muscle mitochondrial respiration in male and female mice exposed to maternal HF diet ''in utero'', followed by postweaning HF diet until middle age. After ''in utero'' exposure to maternal control (Con) or HF diet (45% kcal fat; 39.4% lard, 5.5% soybean oil), offspring were weaned to Con or HF, creating four groups: Con/Con (male/female (m/f), n=8/8), Con/HF (m/f, n=7/4), HF/Con (m/f, n=9/6) and HF/HF (m/f, n=4/4). Oxidative phosphorylation (OXPHOS) and electron transfer system (ETS) capacity were measured in permeabilized gastrocnemius bundles. Maternal HF diet increased fasting glucose and lean body mass in males and body fat percentage in both sexes (P⩽0.05). Maximal adenosine diphosphate-stimulated respiration (complex I OXPHOS) was decreased by maternal HF diet in female offspring (-21%, P=0.053), but not in male (-0%, P>0.05). Sexually divergent responses were exacerbated in offspring weaned to HF diet. In females, OXPHOS capacity was lower (-28%, P=0.041) when weaned to high-fat (HF/HF) v. control diet (HF/Con). In males, OXPHOS (+33%, P=0.009) and ETS (+42%, P=0.016) capacity increased. Our data suggest that maternal lard-based HF diet, rich in saturated fat, affects offspring skeletal muscle respiration in a sex-dependent manner, and these differences are exacerbated by HF diet in adulthood.
s are exacerbated by HF diet in adulthood.  +
Has editor [[Plangger M]]  + , [[Kandolf G]]  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/30111387 PMID: 30111387]  +
Has publicationkeywords Oxidative phosphorylation  + , Developmental programming  + , Fetal programming  + , Respirometry  + , Sexual dimorphism  +
Has title Khamoui AV, Desai M, Ross MG, Rossiter HB (2018) Sex-specific effects of maternal and postweaning high-fat diet on skeletal muscle mitochondrial respiration. J Dev Orig Health Dis 16:1-8.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Gender  + , Developmental biology  + , Exercise physiology;nutrition;life style  +
Pathways N  + , NS  + , ROX  +
Preparation Permeabilized tissue  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab US CA Torrance Rossiter HB +
Was published in journal J Dev Orig Health Dis +
Was published in year 2018  +
Was written by Khamoui AV + , Desai M + , Ross MG + , Rossiter HB +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
13:48:51, 21 August 2018  +
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