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Hafen 2018 J Appl Physiol (1985)
Additional label Labels  + , 2018-08  +
Coupling states OXPHOS  + , ET  +
Enzyme Complex I  + , Complex II;succinate dehydrogenase  + , Complex III  + , Complex IV;cytochrome c oxidase  + , Complex V;ATP synthase  +
Has abstract The heat stress response is associated wit
The heat stress response is associated with several beneficial adaptations that promote cell health and survival. Specifically, ''in vitro'' and animal investigations suggest that repeated exposures to a mild heat stress (~40°C) elicits positive mitochondrial adaptations in skeletal muscle comparable to those observed with exercise. To assess whether such adaptations translate to human skeletal muscle, we produced local, deep tissue heating of the ''vastus lateralis'' via pulsed shortwave diathermy in 20 men (n=10) and women (n=10). Diathermy increased muscle temperature by 3.9 °C within 30 minutes of application. Immediately following a single 2-hr heating session, we observed increased phosphorylation of AMPK and ERK1/2, but not of p38 MAPK nor JNK. Following repeated heat exposures (2-hr daily for 6 consecutive days), we observed a significant cellular heat stress response, as heat shock protein 70 and 90 increased 45% and 38%, respectively. In addition, PGC-1α and mitochondrial electron transport protein complexes I and V expression were increased after heating. These increases were accompanied by augmentation of maximal coupled, and uncoupled, respiratory capacity, measured via high-resolution respirometry. Our data provide the first evidence that mitochondrial adaptation can be elicited in human skeletal muscle in response to repeated exposures to mild heat stress.
to repeated exposures to mild heat stress.  +
Has editor [[Plangger M]]  + , [[Kandolf G]]  +
Has info [ PMID: 30024339]  +
Has publicationkeywords Heat Stress  + , Mitochondrial adaptation  + , Human skeletal muscle  +
Has title Hafen PS, Preece CN, Sorensen JR, Hancock CR, Hyldahl RD (2018) Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle. J Appl Physiol (1985) 125:1447-55.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Respiration  + , Comparative MiP;environmental MiP  +
Pathways N  + , S  + , NS  + , ROX  +
Preparation Permeabilized tissue  +
Stress Temperature  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab US UT Provo Hancock CR +
Was published in journal J Appl Physiol +
Was published in year 2018  +
Was written by Hafen PS + , Preece CN + , Sorensen JR + , Hancock CR + , Hyldahl RD +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
11:04:53, 17 April 2019  +
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