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Gururaja Rao 2019 Cells
Additional label Labels  + , 2019-08  +
Coupling states LEAK  + , OXPHOS  + , ET  +
Diseases Aging;senescence  +
Enzyme Inner mt-membrane transporter  +
Has abstract BK<sub>Ca</sub> channels, orig
BK<sub>Ca</sub> channels, originally discovered in ''Drosophila melanogaster'' as slowpoke (slo), are recognized for their roles in cellular and organ physiology. Pharmacological approaches implicated BK<sub>Ca</sub> channels in cellular and organ protection possibly for their ability to modulate mitochondrial function. However, the direct role of BK<sub>Ca</sub> channels in regulating mitochondrial structure and function is not deciphered. Here, we demonstrate that BK<sub>Ca</sub> channels are present in fly mitochondria, and slo mutants show structural and functional defects in mitochondria. slo mutants display an increase in reactive oxygen species and the modulation of ROS affected their survival. We also found that the absence of BK<sub>Ca</sub> channels reduced the lifespan of ''Drosophila'', and overexpression of human BK<sub>Ca</sub> channels in flies extends life span in males. Our study establishes the presence of BK<sub>Ca</sub> channels in mitochondria of ''Drosophila'' and ascertains its novel physiological role in regulating mitochondrial structural and functional integrity, and lifespan.
al and functional integrity, and lifespan.  +
Has editor [[Plangger M]]  +
Has info [ PMID: 31438578 Open Access]  +
Has publicationkeywords BK<sub>Ca</sub> channels  + , Aging  + , Antioxidants  + , Life span  + , Mitochondria  + , Potassium channel  + , Reactive oxygen species  +
Has title Gururaja Rao S, Bednarczyk P, Towheed A, S
Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BK<sub>Ca</sub> (Slo) channel regulates mitochondrial function and lifespan in ''Drosophila melanogaster''. Cells 8:E945.
''Drosophila melanogaster''. Cells 8:E945.  +
Instrument and method Oxygraph-2k  +
Mammal and model Drosophila  +
MiP area Respiration  + , mt-Membrane  +
Pathways N  + , S  + , NS  + , ROX  +
Preparation Isolated mitochondria  +
Respiration and regulation Ion;substrate transport  +
Was published by MiPNetLab PL Warsaw Bednarczyk P + , US PA Philadelphia Wallace DC + , PL Warsaw Szewczyk A +
Was published in journal Cells +
Was published in year 2019  +
Was written by Gururaja Rao S + , Bednarczyk P + , Towheed A + , Shah K + , Karekar P + , Ponnalagu D + , Jensen HN + , Addya S + , Reyes BAS + , Van Bockstaele EJ + , Szewczyk A + , Wallace DC + , Singh H +
Categories Publications
Modification date
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06:52:57, 26 August 2019  +
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